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Q8I9B4

- MT4_DROME

UniProt

Q8I9B4 - MT4_DROME

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Protein
Metallothionein-4
Gene
MtnD, CG33192
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis By similarity.

GO - Molecular functioni

  1. metal ion binding Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. metal ion homeostasis Source: FlyBase
  2. response to copper ion Source: FlyBase
  3. response to metal ion Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein D
Gene namesi
Name:MtnD
ORF Names:CG33192
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0053192. MtnD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4444Metallothionein-4
PRO_0000197357Add
BLAST

Proteomic databases

PaxDbiQ8I9B4.
PRIDEiQ8I9B4.

Expressioni

Gene expression databases

BgeeiQ8I9B4.

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG295897.
GeneTreeiENSGT00540000073497.
OrthoDBiEOG7FR7KQ.
PhylomeDBiQ8I9B4.

Family and domain databases

InterProiIPR000966. Metalthion_5.
[Graphical view]
PfamiPF02067. Metallothio_5. 1 hit.
[Graphical view]
PRINTSiPR00872. MTDIPTERA.

Sequencei

Sequence statusi: Complete.

Q8I9B4-1 [UniParc]FASTAAdd to Basket

« Hide

MGCKACGTNC QCSATKCGDN CACSQQCQCS CKNGPKDKCC STKN         44
Length:44
Mass (Da):4,545
Last modified:March 1, 2003 - v1
Checksum:i34F0847BFA8BCC7B
GO

Sequence cautioni

The sequence AAO41579.1 differs from that shown. Reason: Erroneous termination at position 32. Translated as Lys.
The sequence ABE01242.1 differs from that shown. Reason: Erroneous termination at position 32. Translated as Lys.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF546903 mRNA. Translation: AAN73050.1.
AE014297 Genomic DNA. Translation: AAO41579.1. Sequence problems.
BT025012 mRNA. Translation: ABE01242.1. Sequence problems.
RefSeqiNP_788695.2. NM_176518.2.
UniGeneiDm.14852.

Genome annotation databases

EnsemblMetazoaiFBtr0308064; FBpp0300409; FBgn0053192.
GeneIDi326270.
KEGGidme:Dmel_CG33192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF546903 mRNA. Translation: AAN73050.1 .
AE014297 Genomic DNA. Translation: AAO41579.1 . Sequence problems.
BT025012 mRNA. Translation: ABE01242.1 . Sequence problems.
RefSeqi NP_788695.2. NM_176518.2.
UniGenei Dm.14852.

3D structure databases

ModBasei Search...

Proteomic databases

PaxDbi Q8I9B4.
PRIDEi Q8I9B4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0308064 ; FBpp0300409 ; FBgn0053192 .
GeneIDi 326270.
KEGGi dme:Dmel_CG33192.

Organism-specific databases

CTDi 326270.
FlyBasei FBgn0053192. MtnD.

Phylogenomic databases

eggNOGi NOG295897.
GeneTreei ENSGT00540000073497.
OrthoDBi EOG7FR7KQ.
PhylomeDBi Q8I9B4.

Miscellaneous databases

GenomeRNAii 326270.
NextBioi 847928.

Gene expression databases

Bgeei Q8I9B4.

Family and domain databases

InterProi IPR000966. Metalthion_5.
[Graphical view ]
Pfami PF02067. Metallothio_5. 1 hit.
[Graphical view ]
PRINTSi PR00872. MTDIPTERA.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis."
    Egli D., Selvaraj A., Yepiskoposyan H., Zhang B., Hafen E., Georgiev O., Schaffner W.
    EMBO J. 22:100-108(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Canton-S.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.

Entry informationi

Entry nameiMT4_DROME
AccessioniPrimary (citable) accession number: Q8I9B4
Secondary accession number(s): Q1WW94, Q86B88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi