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Q8I9B4

- MT4_DROME

UniProt

Q8I9B4 - MT4_DROME

Protein

Metallothionein-4

Gene

MtnD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis By similarity.By similarity

    GO - Molecular functioni

    1. metal ion binding Source: FlyBase

    GO - Biological processi

    1. metal ion homeostasis Source: FlyBase
    2. response to copper ion Source: FlyBase
    3. response to metal ion Source: FlyBase

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-4
    Short name:
    MT-4
    Alternative name(s):
    Metallothionein D
    Gene namesi
    Name:MtnD
    ORF Names:CG33192
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0053192. MtnD.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4444Metallothionein-4PRO_0000197357Add
    BLAST

    Proteomic databases

    PaxDbiQ8I9B4.
    PRIDEiQ8I9B4.

    Expressioni

    Gene expression databases

    BgeeiQ8I9B4.

    Family & Domainsi

    Domaini

    All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG295897.
    GeneTreeiENSGT00540000073497.
    OrthoDBiEOG7FR7KQ.
    PhylomeDBiQ8I9B4.

    Family and domain databases

    InterProiIPR000966. Metalthion_5.
    [Graphical view]
    PfamiPF02067. Metallothio_5. 1 hit.
    [Graphical view]
    PRINTSiPR00872. MTDIPTERA.

    Sequencei

    Sequence statusi: Complete.

    Q8I9B4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCKACGTNC QCSATKCGDN CACSQQCQCS CKNGPKDKCC STKN         44
    Length:44
    Mass (Da):4,545
    Last modified:March 1, 2003 - v1
    Checksum:i34F0847BFA8BCC7B
    GO

    Sequence cautioni

    The sequence AAO41579.1 differs from that shown. Reason: Erroneous termination at position 32. Translated as Lys.
    The sequence ABE01242.1 differs from that shown. Reason: Erroneous termination at position 32. Translated as Lys.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF546903 mRNA. Translation: AAN73050.1.
    AE014297 Genomic DNA. Translation: AAO41579.1. Sequence problems.
    BT025012 mRNA. Translation: ABE01242.1. Sequence problems.
    RefSeqiNP_788695.2. NM_176518.2.
    UniGeneiDm.14852.

    Genome annotation databases

    EnsemblMetazoaiFBtr0308064; FBpp0300409; FBgn0053192.
    GeneIDi326270.
    KEGGidme:Dmel_CG33192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF546903 mRNA. Translation: AAN73050.1 .
    AE014297 Genomic DNA. Translation: AAO41579.1 . Sequence problems.
    BT025012 mRNA. Translation: ABE01242.1 . Sequence problems.
    RefSeqi NP_788695.2. NM_176518.2.
    UniGenei Dm.14852.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8I9B4.
    PRIDEi Q8I9B4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0308064 ; FBpp0300409 ; FBgn0053192 .
    GeneIDi 326270.
    KEGGi dme:Dmel_CG33192.

    Organism-specific databases

    CTDi 326270.
    FlyBasei FBgn0053192. MtnD.

    Phylogenomic databases

    eggNOGi NOG295897.
    GeneTreei ENSGT00540000073497.
    OrthoDBi EOG7FR7KQ.
    PhylomeDBi Q8I9B4.

    Miscellaneous databases

    GenomeRNAii 326270.
    NextBioi 847928.

    Gene expression databases

    Bgeei Q8I9B4.

    Family and domain databases

    InterProi IPR000966. Metalthion_5.
    [Graphical view ]
    Pfami PF02067. Metallothio_5. 1 hit.
    [Graphical view ]
    PRINTSi PR00872. MTDIPTERA.
    ProtoNeti Search...

    Publicationsi

    1. "Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis."
      Egli D., Selvaraj A., Yepiskoposyan H., Zhang B., Hafen E., Georgiev O., Schaffner W.
      EMBO J. 22:100-108(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Canton-S.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.

    Entry informationi

    Entry nameiMT4_DROME
    AccessioniPrimary (citable) accession number: Q8I9B4
    Secondary accession number(s): Q1WW94, Q86B88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Metallothioneins
      Classification of metallothioneins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3