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Protein

Metallothionein-4

Gene

MtnD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis (By similarity).By similarity

GO - Molecular functioni

  • metal ion binding Source: FlyBase

GO - Biological processi

  • metal ion homeostasis Source: FlyBase
  • response to copper ion Source: FlyBase
  • response to metal ion Source: FlyBase

Keywordsi

LigandCadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein D
Gene namesi
Name:MtnD
ORF Names:CG33192
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0053192. MtnD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973571 – 44Metallothionein-4Add BLAST44

Proteomic databases

PaxDbiQ8I9B4.
PRIDEiQ8I9B4.

Expressioni

Gene expression databases

BgeeiFBgn0053192.
GenevisibleiQ8I9B4. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0300409.

Structurei

3D structure databases

SMRiQ8I9B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KBV5. Eukaryota.
ENOG4110MWJ. LUCA.
InParanoidiQ8I9B4.
PhylomeDBiQ8I9B4.

Family and domain databases

InterProiView protein in InterPro
IPR000966. Metalthion_5.
PfamiView protein in Pfam
PF02067. Metallothio_5. 1 hit.
PRINTSiPR00872. MTDIPTERA.

Sequencei

Sequence statusi: Complete.

Q8I9B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MGCKACGTNC QCSATKCGDN CACSQQCQCS CKNGPKDKCC STKN
Length:44
Mass (Da):4,545
Last modified:March 1, 2003 - v1
Checksum:i34F0847BFA8BCC7B
GO

Sequence cautioni

The sequence ABE01242 differs from that shown. Reason: Erroneous termination at position 32. Translated as Lys.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546903 mRNA. Translation: AAN73050.1.
AE014297 Genomic DNA. Translation: AAO41579.2.
BT025012 mRNA. Translation: ABE01242.1. Sequence problems.
RefSeqiNP_788695.2. NM_176518.2.
UniGeneiDm.14852.

Genome annotation databases

EnsemblMetazoaiFBtr0308064; FBpp0300409; FBgn0053192.
GeneIDi326270.
KEGGidme:Dmel_CG33192.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT4_DROME
AccessioniPrimary (citable) accession number: Q8I9B4
Secondary accession number(s): Q1WW94, Q86B88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: April 12, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families