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Protein

Transcription-associated protein 1

Gene

Nipped-A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.1 Publication

GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: GO_Central
  • histone acetylation Source: UniProtKB
  • histone exchange Source: UniProtKB
  • histone H3 acetylation Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of Notch signaling pathway Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB
  • wing disc pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ8I8U7.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription-associated protein 1
Alternative name(s):
dTRA1
Gene namesi
Name:Nipped-A
Synonyms:Tra1
ORF Names:CG2905
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0053554. Nipped-A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • histone acetyltransferase complex Source: UniProtKB
  • microtubule associated complex Source: FlyBase
  • NuA4 histone acetyltransferase complex Source: UniProtKB
  • nucleus Source: FlyBase
  • polytene chromosome Source: FlyBase
  • polytene chromosome puff Source: FlyBase
  • SAGA complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 38033803Transcription-associated protein 1PRO_0000088853Add
BLAST

Proteomic databases

PaxDbiQ8I8U7.
PRIDEiQ8I8U7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiQ8I8U7.
GenevisibleiQ8I8U7. DM.

Interactioni

Subunit structurei

Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1. Probable component of some SAGA complex. Interacts with SPT3, PCAF/GCN5, DIK and ADA2S.2 Publications

Protein-protein interaction databases

BioGridi61398. 11 interactions.
IntActiQ8I8U7. 17 interactions.
MINTiMINT-6178917.
STRINGi7227.FBpp0085431.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati158 – 19639HEAT 1Add
BLAST
Repeati397 – 44347HEAT 2Add
BLAST
Repeati802 – 84039HEAT 3Add
BLAST
Repeati1247 – 128539HEAT 4Add
BLAST
Repeati1394 – 143239HEAT 5Add
BLAST
Repeati1888 – 192639HEAT 6Add
BLAST
Domaini2640 – 3186547FATPROSITE-ProRule annotationAdd
BLAST
Domaini3470 – 3734265PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini3771 – 380333FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 6 HEAT repeats.Curated
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0889. Eukaryota.
COG5032. LUCA.
InParanoidiQ8I8U7.
OMAiTHEHIVT.
OrthoDBiEOG7VHSW8.
PhylomeDBiQ8I8U7.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR033317. TRA1/TRRAP.
[Graphical view]
PANTHERiPTHR11139:SF1. PTHR11139:SF1. 7 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 16 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I8U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIENVPVN TFRNYLNILN DSSSKDELKL KATQELSEHF EMIMQSPAYP
60 70 80 90 100
SFLDNSLKIF MRILQDGEPQ FIQENTMQHN LSKDVMLVAT ATVLAMNRLG
110 120 130 140 150
TFVSCRALLD SGSQLHLIHP YLHISFNLRR RNRSTGVGDF SFDTHEMIHR
160 170 180 190 200
LPITESLRQH VKTIITMMLK ILKTDNEENV LVCLRIIIEL HKHFRPSFNS
210 220 230 240 250
EGMVEIPKER LDESHALEVI VTDLCGPFFY KPEACNKAPV KCYIQLFLGF
260 270 280 290 300
VKEIYTNLPN HLTSIFETSN DVWVTDLKDL NLEVLLSESY SVRTIHVEKA
310 320 330 340 350
LDSNSQQQII RVDDEELIDD IIRDSRCFNS SAKLLHAFAK VSPIKSLFSS
360 370 380 390 400
SGRAKVSIEK GPSSVPTKRL NLMKNCPKEA AHLRKELLIA ARHIFATDLR
410 420 430 440 450
QKFIPSIEQL FDEDLLIGKG VTLDSIRPLA YSTLADLAHH VRQSLNIDVL
460 470 480 490 500
IKAVNLFSKN VHDESLAVGI QTMSCKLLLN LVDCLRHHSE TEPQRSKALL
510 520 530 540 550
SKLLKVFVKK FETIAKIQLP LIIQKCKGHA FSGALVNSSG NASLSHINAP
560 570 580 590 600
DLKDDISNIQ VSASGSQWIY SVNVAEFRSL VKTLVGGVKT ITWGFFNSKF
610 620 630 640 650
QLTDTKLANH EKIFGPEIVC SYIDLVYYAM EALDIYTINV NPNQQRTSGL
660 670 680 690 700
ISRSKEEKEV LEHFSGIFLM MHSQNFQEIF STTINFLVER IYKNQSLQVI
710 720 730 740 750
ANSFLANPTT SPLFATVLVE YLLNKMEEMG SNLERSNLYL RLFKLVFGSV
760 770 780 790 800
SLFPVENEQM LRPHLHKIVN RSMELALISE EPYNYFLLLR ALFRSIGGGS
810 820 830 840 850
HDLLYQEFLP LLPNLLEGLN RLQSGFHKQH MRDLFVELCL TVPVRLSSLL
860 870 880 890 900
PYLPMLMDPL VSALNGSPTL ISQGLRTLEL CVDNLQPDFL YDHIQPVRAA
910 920 930 940 950
LMQALWKTLR NQDNAALVAF RVLGKFGGGN RKMMVEPQAL SYIINDKPTI
960 970 980 990 1000
SIVTYFQEYE TPIDFPVDEA IKSAFRALGS NSTDQFYRRQ SWEVIRCFLA
1010 1020 1030 1040 1050
AFISLDDEKH MLLKLFTHVD FVENKIMNWS TFQHKAGNET VRETHQTALI
1060 1070 1080 1090 1100
GMLVASATKD LRDSVCPVMA AVVRHYTMVA IAQQAGPFPQ KGYQATHGID
1110 1120 1130 1140 1150
PMILIDALAS CMGHEEKELC KPGIACMGII LDTATNIMGN KDRACKLPII
1160 1170 1180 1190 1200
QYLAEKMVSL CYDRPWYSKV GGCQAIQFLC KHMSLRALFQ NLFNFLKAFM
1210 1220 1230 1240 1250
FVLMDLEGDV SNGAIEITKS YMKSMLEICL TPINECYKNI DLKDLQAKAT
1260 1270 1280 1290 1300
YEVIHELVRH ITSPNTIVRE ESMVLLKHIG TIQSKTVSEV MDPHKDVLAD
1310 1320 1330 1340 1350
IIPPKKHLLR HQPANAQIGL MDGNTFCTTL EPRLFTIDLT NTYHKLFFHE
1360 1370 1380 1390 1400
LLTLSEAEDA TLAKLDCYKN VPNLIPLRTS ALRALAACHY ISDIGYKEKI
1410 1420 1430 1440 1450
INIIFKVMES DKSELQTTAF HCMKHFITGV TLEKEKVQSA MRPLLLKLGD
1460 1470 1480 1490 1500
HRNLSIPAIK RLSYFTQIFP QMFNEKLSEQ ILQHCSKIME IFVSEYKSTS
1510 1520 1530 1540 1550
PNVNFFASSK GGEYEQKIVI LIEMFFYISA SVKYIEKLCQ LVLKTEKNLM
1560 1570 1580 1590 1600
IEASSPYREA LIKFLQRFPT ETVDLFLTES LMIDPQWNRL FIYLLKHETG
1610 1620 1630 1640 1650
VSFRAVIKSS RYNNLIHYLN THTEFPEALK YEIQHQAVLI IFTLMESDDQ
1660 1670 1680 1690 1700
WIPTRQDIVD ALKNCWQNYL STLSSEDVLC DLWHLIGKIL LHYFSNNTND
1710 1720 1730 1740 1750
IELLFQLLRA LCFRFIPDVY FLRDFLQHTV AQSFTVNWKR NAFFYFVENF
1760 1770 1780 1790 1800
NNSFLSEELK AKIITAVIIP CFAVSFDKGE GNKLIGAPPT PYQEDEKNIV
1810 1820 1830 1840 1850
SVFINKVFDP DKQYDDAVRI ALLQLACLLV ERASQHIHDG DANNKRQGNK
1860 1870 1880 1890 1900
LRRLMTFAWP CLLSKSSVDP TARYHGHLLL SHIIARLAIH KKIVLQVFHS
1910 1920 1930 1940 1950
LLKGHALEAR SIVKQALDVL TPAMPLRMED GNTMLTHWTK KIIVEEGHAM
1960 1970 1980 1990 2000
QQLFHILQLI IRHYKVYFPV RHQLVQHLIN YMQRLGFPPT ASIEHKKLAV
2010 2020 2030 2040 2050
DLAEVIIKWE LHRIKDDRET KTDGTEEELI QESSVKRSGI DLVETRKKSF
2060 2070 2080 2090 2100
DIIRETTVQG KCVMLLKMAM RPEIWPQPFD IKLNWLDKVL ATVETPHHNL
2110 2120 2130 2140 2150
NNICTGIDFL TFLTTILSPD QLVSIIRPVQ RGLSLCIIHQ NTRIVRLMHM
2160 2170 2180 2190 2200
FLTRIMAIFP PDTQHKHEDL DLLYTAVSKM IAENLTSYEK SPQPNASSLF
2210 2220 2230 2240 2250
GTLMILKACT TNNASYIDRI LVQFIRVLNH LTRDHINTIG GNTVISQSPD
2260 2270 2280 2290 2300
SNALPLELLV LSLELIKNRI FVMSVEIRKL FIGTILVSLI EKSTEVKIIK
2310 2320 2330 2340 2350
CIIKMLDEWI KTKEPNVMTQ VPSIREKSAL LVKLMQNVEK KFTDEIELNI
2360 2370 2380 2390 2400
QFLEIINFIY RDEILKQTEL TNKLEGAFLN GLRFQNPNVR SKFFEILDSS
2410 2420 2430 2440 2450
MRRRLHDRLL YIICSQAWDT IGSHYWIKQC IELLILTANT MMQIQCSNEQ
2460 2470 2480 2490 2500
FKIPSITSVI PVNSSETQEN SFVSFLSSHS ESFDIIQTVD DKDDVYDIDL
2510 2520 2530 2540 2550
NADRKEDCQQ ILPNRRVTLV ELVYKQAEFL EANRNIRTDQ MLVATSQLCH
2560 2570 2580 2590 2600
IDTQLAQSVW LSMFPRIWSI FTEDQRCNIT KELIPFLSSG TNVNQKDCHP
2610 2620 2630 2640 2650
STLNTFVESL TKCAPPIYIP PNLLAYLGKS HNLWHRAILV LEDMAVNQSM
2660 2670 2680 2690 2700
QSKDIDGGEN QFSDLDVQQS NNIFDSLSKM YSSMHEEDLW AGLWLKFAHY
2710 2720 2730 2740 2750
PETNIAVSYE QMGFFEEAQG AYDLAMTKFK QDLSNGVVNT YVNSELLLWE
2760 2770 2780 2790 2800
NHWMRCAKEL NQWDILLDYA QTNKDKNMFL ILESSWRVPD WNLMKIALAK
2810 2820 2830 2840 2850
TEQCYLKHYG FKINLYKGYL SILHQEERQT GNIERYVEIA SSLCIREWRR
2860 2870 2880 2890 2900
LPNIVSHIHL PYLQASQQIM ELHEASQIHQ GLAQSRNNSL HDMKAIVKTW
2910 2920 2930 2940 2950
RNRLPIISDD LSHWSDIFTW RQHHYQIITQ HLEQQSDQGS TMLGVHASAQ
2960 2970 2980 2990 3000
AIISFGKIAR KHNLTGVCQE TLSRIYTIPS VPIVDCFQKI RQQVKCYLQM
3010 3020 3030 3040 3050
PSTSGKNEIN EALEVIESTN LKYFTGEMNA EFYALKGLLL AQIGRSEEAG
3060 3070 3080 3090 3100
KSFSVAAQLH DGLTKAWAMW GDYMEQIFLK ERKITLAVDA LICYLQASRN
3110 3120 3130 3140 3150
QIESKTRKYI AKVLWFLSYD NNTKILISTL EKHVAGIPPS YWLPWIPQLL
3160 3170 3180 3190 3200
CCLEQFEGDV ILNLLSQIGR LYPQAVYFPI RTLYLTLKIE QREKHKTAEQ
3210 3220 3230 3240 3250
AVKSSCSNID GTTLSFGRGA SHGNIPSINP IKATPPMWRC SKVMQLQREV
3260 3270 3280 3290 3300
HPTILSSLEG IVDQMVWFRE SWTEEVLRQL RQGLIKCYAI AFEKRDTVQH
3310 3320 3330 3340 3350
STITPHTLHF VKKLGSTFGI GIENVPGSVT SSISNSAASE SLARRAQVTF
3360 3370 3380 3390 3400
QDPVFQKMKE QFTNDFDFSK PGAMKLHNLI SKLKTWIKVL ETKVKKLPTS
3410 3420 3430 3440 3450
FLIEDKCRFL SNFSQKTAEV ELPGELLIPL SSHYYVRIAR FMPRVEIVQK
3460 3470 3480 3490 3500
NNTAARRLYI RGTNGKIYPY LVVLDSGLGD ARREERVLQL KRMLNYYLEK
3510 3520 3530 3540 3550
QKETSRRFLN ITVPRVVPIS PQMRLAEDNP NSISLLKIFK KCCQSMQVDY
3560 3570 3580 3590 3600
DMPIVKYYDR LSEVQARGTP TTHTLLREIF SEIQWTMVPK TLLKHWALKT
3610 3620 3630 3640 3650
FLAATDFWHF RKMLTLQLAL AFLCEHALNL TRLNADMMYL HQDSGLMNIS
3660 3670 3680 3690 3700
YFKFDVNDDK CQLNQHRPVP FRLTPNVGEF ITHFGITGPL SAAIVATARC
3710 3720 3730 3740 3750
FIQPNYKLSS ILQTILRDEI IALQKKGFRE CKLIEGSEDR YSDGNCMEHS
3760 3770 3780 3790 3800
VNIVNSAVDI IMTRFNKISY FDSIENKKIS VLVQSATNID NLCRMDPAWH

PWL
Length:3,803
Mass (Da):436,498
Last modified:January 15, 2008 - v3
Checksum:iD2705A28D1E65D02
GO

Sequence cautioni

The sequence AAM11122.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691R → M in AAN52145 (PubMed:12697829).Curated
Sequence conflicti530 – 5301A → T in AAM11122 (PubMed:12537569).Curated
Sequence conflicti656 – 6605EEKEV → KKKKK in AAM11122 (PubMed:12537569).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY142217 mRNA. Translation: AAN52145.1.
AE013599 Genomic DNA. Translation: AAF57342.3.
AY094769 mRNA. Translation: AAM11122.1. Different initiation.

Genome annotation databases

UCSCiCG33554-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY142217 mRNA. Translation: AAN52145.1.
AE013599 Genomic DNA. Translation: AAF57342.3.
AY094769 mRNA. Translation: AAM11122.1. Different initiation.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61398. 11 interactions.
IntActiQ8I8U7. 17 interactions.
MINTiMINT-6178917.
STRINGi7227.FBpp0085431.

Proteomic databases

PaxDbiQ8I8U7.
PRIDEiQ8I8U7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiCG33554-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0053554. Nipped-A.

Phylogenomic databases

eggNOGiKOG0889. Eukaryota.
COG5032. LUCA.
InParanoidiQ8I8U7.
OMAiTHEHIVT.
OrthoDBiEOG7VHSW8.
PhylomeDBiQ8I8U7.

Enzyme and pathway databases

SignaLinkiQ8I8U7.

Miscellaneous databases

ChiTaRSiNipped-A. fly.
PROiQ8I8U7.

Gene expression databases

BgeeiQ8I8U7.
GenevisibleiQ8I8U7. DM.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR033317. TRA1/TRRAP.
[Graphical view]
PANTHERiPTHR11139:SF1. PTHR11139:SF1. 7 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 16 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two Drosophila Ada2 homologues function in different multiprotein complexes."
    Kusch T., Guelman S., Abmayr S.M., Workman J.L.
    Mol. Cell. Biol. 23:3305-3319(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH SPT3; PCAF; DIK AND ADA2S.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 419-660.
    Strain: Berkeley.
    Tissue: Ovary.
  5. "Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions."
    Kusch T., Florens L., Macdonald W.H., Swanson S.K., Glaser R.L., Yates J.R. III, Abmayr S.M., Washburn M.P., Workman J.L.
    Science 306:2084-2087(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TIP60 COMPLEX, FUNCTION.

Entry informationi

Entry nameiTRA1_DROME
AccessioniPrimary (citable) accession number: Q8I8U7
Secondary accession number(s): Q8T3L7, Q9V9E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

Although strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, suggesting that it probably lacks such activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.