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Q8I8T0 (Q8I8T0_ANOGA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Odorant-binding protein AgamOBP1 EMBL AAO12081.1
Gene names
Name:AgamOBP1 EMBL AAO12081.1
Synonyms:OBP17 EMBL EAU75992.1
ORF Names:AgaP_AGAP003309 EMBL EAU75992.1, agCG48275 EMBL AAO12081.1
OrganismAnopheles gambiae (African malaria mosquito) [Reference proteome] EMBL AAO12081.1
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site641Chloride 1; via amide nitrogen PDB 3N7H
Binding site1041Chloride 2 PDB 3N7H

Sequences

Sequence LengthMass (Da)Tools
Q8I8T0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 262F0A0BAE511B46

FASTA14416,553
        10         20         30         40         50         60 
MKLVTFVFAA LLCCSMTLGD TTPRRDAEYP PPELLEALKP LHDICLGKTG VTEEAIKKFS 

        70         80         90        100        110        120 
DEEIHEDEKL KCYMNCLFHE AKVVDDNGDV HLEKLHDSLP SSMHDIAMHM GKRCLYPEGE 

       130        140 
TLCDKAFWLH KCWKQSDPKH YFLV 

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References

« Hide 'large scale' references
[1]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST EMBL EAU75992.1.
[2]The Anopheles Genome Sequencing Consortium
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PEST EMBL EAU75992.1.
[3]Xu P., Smith D.P.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]"Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae."
Xu P.X., Zwiebel L.J., Smith D.P.
Insect Mol. Biol. 12:549-560(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[5]"The Anopheles gambiae genome: an update."
Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.
Trends Parasitol. 20:49-52(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PEST EMBL EAU75992.1.
[6]"The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism."
Wogulis M., Morgan T., Ishida Y., Leal W.S., Wilson D.K.
Biochem. Biophys. Res. Commun. 339:157-164(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-144.
[7]"Update of the Anopheles gambiae PEST genome assembly."
Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F., Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.
Genome Biol. 8:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PEST EMBL EAU75992.1.
[8]VectorBase
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PEST EMBL EAU75992.1.
[9]"Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents."
Tsitsanou K.E., Thireou T., Drakou C.E., Koussis K., Keramioti M.V., Leonidas D.D., Eliopoulos E., Iatrou K., Zographos S.E.
Cell. Mol. Life Sci. 69:283-297(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 20-144 IN COMPLEX WITH CHLORIDE.
[10]"Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET)."
Murphy E.J., Booth J.C., Davrazou F., Port A.M., Jones D.N.
J. Biol. Chem. 288:4475-4485(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 20-144.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY146721 Genomic DNA. Translation: AAO12081.1.
AAAB01008982 Genomic DNA. Translation: EAU75992.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ERBX-ray1.50A/B20-144[»]
3N7HX-ray1.60A/B20-144[»]
4FQTX-ray2.20A/B20-144[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP003309-RA; AGAP003309-PA; AGAP003309.
KEGGaga:AgaP_AGAP003309.
VectorBaseAGAP003309. Anopheles gambiae.

Organism-specific databases

CTD657254.

Phylogenomic databases

HOGENOMHOG000044371.

Family and domain databases

Gene3D1.10.238.20. 1 hit.
InterProIPR006170. PBP_GOBP.
IPR023316. PBP_GOBP_dom.
[Graphical view]
PfamPF01395. PBP_GOBP. 1 hit.
[Graphical view]
PRINTSPR00485. MEALWORMBTLB.
SMARTSM00708. PhBP. 1 hit.
[Graphical view]
SUPFAMSSF47565. SSF47565. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8I8T0.

Entry information

Entry nameQ8I8T0_ANOGA
AccessionPrimary (citable) accession number: Q8I8T0
Secondary accession number(s): A0NG65
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)