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Protein
Submitted name:

AGAP003309-PA

Gene

AgamOBP1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. odorant binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
AGAP003309-PAImported
Submitted name:
Odorant-binding protein AgamOBP1Imported
Gene namesi
Name:AgamOBP1Imported
Synonyms:OBP17Imported
ORF Names:AgaP_AGAP003309Imported, agCG48275Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 2R

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 76Combined sources
Disulfide bondi72 ↔ 123Combined sources
Disulfide bondi114 ↔ 132Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ERBX-ray1.50A/B20-144[»]
3N7HX-ray1.60A/B20-144[»]
4FQTX-ray2.20A/B20-144[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8I8T0.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000044371.

Family and domain databases

Gene3Di1.10.238.20. 1 hit.
InterProiIPR006170. PBP_GOBP.
IPR023316. PBP_GOBP_dom.
[Graphical view]
PfamiPF01395. PBP_GOBP. 1 hit.
[Graphical view]
PRINTSiPR00485. MEALWORMBTLB.
SMARTiSM00708. PhBP. 1 hit.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I8T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVTFVFAA LLCCSMTLGD TTPRRDAEYP PPELLEALKP LHDICLGKTG
60 70 80 90 100
VTEEAIKKFS DEEIHEDEKL KCYMNCLFHE AKVVDDNGDV HLEKLHDSLP
110 120 130 140
SSMHDIAMHM GKRCLYPEGE TLCDKAFWLH KCWKQSDPKH YFLV
Length:144
Mass (Da):16,553
Last modified:March 1, 2003 - v1
Checksum:i262F0A0BAE511B46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146721 Genomic DNA. Translation: AAO12081.1.
AAAB01008982 Genomic DNA. Translation: EAU75992.1.
RefSeqiXP_001231183.1. XM_001231182.1.

Genome annotation databases

EnsemblMetazoaiAGAP003309-RA; AGAP003309-PA; AGAP003309.
GeneIDi1279770.
KEGGiaga:AgaP_AGAP003309.
VectorBaseiAGAP003309. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146721 Genomic DNA. Translation: AAO12081.1.
AAAB01008982 Genomic DNA. Translation: EAU75992.1.
RefSeqiXP_001231183.1. XM_001231182.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ERBX-ray1.50A/B20-144[»]
3N7HX-ray1.60A/B20-144[»]
4FQTX-ray2.20A/B20-144[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP003309-RA; AGAP003309-PA; AGAP003309.
GeneIDi1279770.
KEGGiaga:AgaP_AGAP003309.
VectorBaseiAGAP003309. Anopheles gambiae.

Organism-specific databases

CTDi552478.

Phylogenomic databases

HOGENOMiHOG000044371.

Miscellaneous databases

EvolutionaryTraceiQ8I8T0.

Family and domain databases

Gene3Di1.10.238.20. 1 hit.
InterProiIPR006170. PBP_GOBP.
IPR023316. PBP_GOBP_dom.
[Graphical view]
PfamiPF01395. PBP_GOBP. 1 hit.
[Graphical view]
PRINTSiPR00485. MEALWORMBTLB.
SMARTiSM00708. PhBP. 1 hit.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R., Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E., Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PESTImported.
  2. The Anopheles Genome Sequencing Consortium
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.
  3. Xu P., Smith D.P.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae."
    Xu P.X., Zwiebel L.J., Smith D.P.
    Insect Mol. Biol. 12:549-560(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.
  6. "The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism."
    Wogulis M., Morgan T., Ishida Y., Leal W.S., Wilson D.K.
    Biochem. Biophys. Res. Commun. 339:157-164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-144, ACTIVE SITE.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.
  8. VectorBase
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PESTImported.
  9. "Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents."
    Tsitsanou K.E., Thireou T., Drakou C.E., Koussis K., Keramioti M.V., Leonidas D.D., Eliopoulos E., Iatrou K., Zographos S.E.
    Cell. Mol. Life Sci. 69:283-297(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 20-144, ACTIVE SITE.
  10. "Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET)."
    Murphy E.J., Booth J.C., Davrazou F., Port A.M., Jones D.N.
    J. Biol. Chem. 288:4475-4485(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 20-144, ACTIVE SITE.

Entry informationi

Entry nameiQ8I8T0_ANOGA
AccessioniPrimary (citable) accession number: Q8I8T0
Secondary accession number(s): A0NG65
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.