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Q8I8T0

- Q8I8T0_ANOGA

UniProt

Q8I8T0 - Q8I8T0_ANOGA

Protein
Submitted name:

AGAP003309-PA

Gene

AgamOBP1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641Chloride 1; via amide nitrogenImported
    Binding sitei104 – 1041Chloride 2Imported

    GO - Molecular functioni

    1. odorant binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    AGAP003309-PAImported
    Submitted name:
    Odorant-binding protein AgamOBP1Imported
    Gene namesi
    Name:AgamOBP1Imported
    Synonyms:OBP17Imported
    ORF Names:AgaP_AGAP003309Imported, agCG48275Imported
    OrganismiAnopheles gambiae (African malaria mosquito)Imported
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome 2R

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ERBX-ray1.50A/B20-144[»]
    3N7HX-ray1.60A/B20-144[»]
    4FQTX-ray2.20A/B20-144[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8I8T0.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000044371.

    Family and domain databases

    Gene3Di1.10.238.20. 1 hit.
    InterProiIPR006170. PBP_GOBP.
    IPR023316. PBP_GOBP_dom.
    [Graphical view]
    PfamiPF01395. PBP_GOBP. 1 hit.
    [Graphical view]
    PRINTSiPR00485. MEALWORMBTLB.
    SMARTiSM00708. PhBP. 1 hit.
    [Graphical view]
    SUPFAMiSSF47565. SSF47565. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8I8T0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLVTFVFAA LLCCSMTLGD TTPRRDAEYP PPELLEALKP LHDICLGKTG    50
    VTEEAIKKFS DEEIHEDEKL KCYMNCLFHE AKVVDDNGDV HLEKLHDSLP 100
    SSMHDIAMHM GKRCLYPEGE TLCDKAFWLH KCWKQSDPKH YFLV 144
    Length:144
    Mass (Da):16,553
    Last modified:March 1, 2003 - v1
    Checksum:i262F0A0BAE511B46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY146721 Genomic DNA. Translation: AAO12081.1.
    AAAB01008982 Genomic DNA. Translation: EAU75992.1.
    RefSeqiXP_001231183.1. XM_001231182.1.

    Genome annotation databases

    EnsemblMetazoaiAGAP003309-RA; AGAP003309-PA; AGAP003309.
    GeneIDi1279770.
    KEGGiaga:AgaP_AGAP003309.
    VectorBaseiAGAP003309. Anopheles gambiae.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY146721 Genomic DNA. Translation: AAO12081.1 .
    AAAB01008982 Genomic DNA. Translation: EAU75992.1 .
    RefSeqi XP_001231183.1. XM_001231182.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ERB X-ray 1.50 A/B 20-144 [» ]
    3N7H X-ray 1.60 A/B 20-144 [» ]
    4FQT X-ray 2.20 A/B 20-144 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP003309-RA ; AGAP003309-PA ; AGAP003309 .
    GeneIDi 1279770.
    KEGGi aga:AgaP_AGAP003309.
    VectorBasei AGAP003309. Anopheles gambiae.

    Organism-specific databases

    CTDi 552478.

    Phylogenomic databases

    HOGENOMi HOG000044371.

    Miscellaneous databases

    EvolutionaryTracei Q8I8T0.

    Family and domain databases

    Gene3Di 1.10.238.20. 1 hit.
    InterProi IPR006170. PBP_GOBP.
    IPR023316. PBP_GOBP_dom.
    [Graphical view ]
    Pfami PF01395. PBP_GOBP. 1 hit.
    [Graphical view ]
    PRINTSi PR00485. MEALWORMBTLB.
    SMARTi SM00708. PhBP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47565. SSF47565. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PESTImported.
    2. The Anopheles Genome Sequencing Consortium
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PESTImported.
    3. Xu P., Smith D.P.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae."
      Xu P.X., Zwiebel L.J., Smith D.P.
      Insect Mol. Biol. 12:549-560(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PESTImported.
    6. "The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism."
      Wogulis M., Morgan T., Ishida Y., Leal W.S., Wilson D.K.
      Biochem. Biophys. Res. Commun. 339:157-164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-144.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PESTImported.
    8. VectorBase
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PESTImported.
    9. "Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents."
      Tsitsanou K.E., Thireou T., Drakou C.E., Koussis K., Keramioti M.V., Leonidas D.D., Eliopoulos E., Iatrou K., Zographos S.E.
      Cell. Mol. Life Sci. 69:283-297(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 20-144.
    10. "Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET)."
      Murphy E.J., Booth J.C., Davrazou F., Port A.M., Jones D.N.
      J. Biol. Chem. 288:4475-4485(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 20-144.

    Entry informationi

    Entry nameiQ8I8T0_ANOGA
    AccessioniPrimary (citable) accession number: Q8I8T0
    Secondary accession number(s): A0NG65
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3