Q8I8T0 (Q8I8T0_ANOGA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
AGAP003309-PA EMBL EAU75992.1

Submitted name:
Odorant-binding protein AgamOBP1 EMBL AAO12081.1

Gene names

Name:	AgamOBP1 EMBL AAO12081.1
Synonyms:	OBP17 EMBL EAU75992.1
ORF Names:	AgaP_AGAP003309 EMBL EAU75992.1, agCG48275 EMBL AAO12081.1

Organism

Anopheles gambiae (African malaria mosquito) [Reference proteome] EMBL AAO12081.1

Taxonomic identifier

7165 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Anophelinae › Anopheles › Cellia › Pyretophorus › gambiae species complex

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 4FQT PDB 3N7H PDB 2ERB Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	odorant binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8I8T0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 262F0A0BAE511B46	FASTA	144	16,553
	10 20 30 40 50 60 MKLVTFVFAA LLCCSMTLGD TTPRRDAEYP PPELLEALKP LHDICLGKTG VTEEAIKKFS 70 80 90 100 110 120 DEEIHEDEKL KCYMNCLFHE AKVVDDNGDV HLEKLHDSLP SSMHDIAMHM GKRCLYPEGE 130 140 TLCDKAFWLH KCWKQSDPKH YFLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L. Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST EMBL EAU75992.1.
[2]	The Anopheles Genome Sequencing Consortium Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: PEST EMBL EAU75992.1.
[3]	Xu P., Smith D.P. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae." Xu P.X., Zwiebel L.J., Smith D.P. Insect Mol. Biol. 12:549-560(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"The Anopheles gambiae genome: an update." Mongin E., Louis C., Holt R.A., Birney E., Collins F.H. Trends Parasitol. 20:49-52(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: PEST EMBL EAU75992.1.
[6]	"The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism." Wogulis M., Morgan T., Ishida Y., Leal W.S., Wilson D.K. Biochem. Biophys. Res. Commun. 339:157-164(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-144.
[7]	"Update of the Anopheles gambiae PEST genome assembly." Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F., Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H. Genome Biol. 8:R5-R5(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: PEST EMBL EAU75992.1.
[8]	VectorBase Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: PEST EMBL EAU75992.1.
[9]	"Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents." Tsitsanou K.E., Thireou T., Drakou C.E., Koussis K., Keramioti M.V., Leonidas D.D., Eliopoulos E., Iatrou K., Zographos S.E. Cell. Mol. Life Sci. 69:283-297(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 20-144.
[10]	"Interactions of Anopheles gambiae Odorant-binding Proteins with a Human-derived Repellent: IMPLICATIONS FOR THE MODE OF ACTION OF N,N-DIETHYL-3-METHYLBENZAMIDE (DEET)." Murphy E.J., Booth J.C., Davrazou F., Port A.M., Jones D.N. J. Biol. Chem. 288:4475-4485(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 20-144.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY146721 Genomic DNA. Translation: AAO12081.1.
AAAB01008982 Genomic DNA. Translation: EAU75992.1.

RefSeq

XP_001231183.1. XM_001231182.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ERB	X-ray	1.50	A/B	20-144	[»]
3N7H	X-ray	1.60	A/B	20-144	[»]
4FQT	X-ray	2.20	A/B	20-144	[»]

SMR

Q8I8T0. Positions 22-144.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

AGAP003309-RA; AGAP003309-PA; AGAP003309.

GeneID

1279770.

KEGG

aga:AgaP_AGAP003309.

VectorBase

AGAP003309. Anopheles gambiae.

Organism-specific databases

CTD

657254.

Phylogenomic databases

HOGENOM

HOG000044371.

Family and domain databases

Gene3D

1.10.238.20. 1 hit.

InterPro

IPR006170. PBP_GOBP.
IPR023316. PBP_GOBP_dom.
[Graphical view]

Pfam

PF01395. PBP_GOBP. 1 hit.
[Graphical view]

PRINTS

PR00485. MEALWORMBTLB.

SMART

SM00708. PhBP. 1 hit.
[Graphical view]

SUPFAM

SSF47565. PBP_GOBP. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q8I8T0.

Entry information

Entry name

Q8I8T0_ANOGA

Accession

Primary (citable) accession number: Q8I8T0
Secondary accession number(s): A0NG65

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)