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Protein

LIM and SH3 domain protein Lasp

Gene

Lasp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • muscle thin filament assembly Source: FlyBase
  • pole cell formation Source: FlyBase
  • positive regulation of pole plasm oskar mRNA localization Source: FlyBase
  • regulation of myofibril size Source: FlyBase
  • sarcomere organization Source: FlyBase
  • spermatogenesis Source: FlyBase
  • sperm individualization Source: FlyBase

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ8I7C3

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and SH3 domain protein Lasp
Gene namesi
Name:LaspImported
ORF Names:CG3849
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0063485 Lasp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757661 – 657LIM and SH3 domain protein LaspAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei505Phosphoserine1 Publication1
Modified residuei530Phosphoserine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8I7C3
PRIDEiQ8I7C3

PTM databases

iPTMnetiQ8I7C3

Expressioni

Gene expression databases

BgeeiFBgn0063485
ExpressionAtlasiQ8I7C3 baseline and differential
GenevisibleiQ8I7C3 DM

Interactioni

Subunit structurei

Interacts with osk.

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi65163, 17 interactors
IntActiQ8I7C3, 14 interactors
STRINGi7227.FBpp0099495

Structurei

3D structure databases

ProteinModelPortaliQ8I7C3
SMRiQ8I7C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 63LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61
Repeati64 – 95Nebulin 1Add BLAST32
Repeati96 – 130Nebulin 2Add BLAST35
Domaini596 – 657SH3PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 594Gln-richAdd BLAST417
Compositional biasi217 – 220Poly-Pro4

Keywords - Domaini

LIM domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG1702 Eukaryota
ENOG4111GQ8 LUCA
GeneTreeiENSGT00530000062924
InParanoidiQ8I7C3
OrthoDBiEOG091G0KA2
PhylomeDBiQ8I7C3

Family and domain databases

InterProiView protein in InterPro
IPR000900 Nebulin_repeat
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 2 hits
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 2 hits
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 Publication (identifier: Q8I7C3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKTCARCQK VVYPIEELKC LDKTWHKTCF KCTECGMTLN MKTYKGYNKM
60 70 80 90 100
PYCEAHIPKA KATAIADTPE LKRIAENTKI QSNVKYHADF EKAKGKFTQV
110 120 130 140 150
ADDPETLRIK QNTKHISNVA YHGDLEKKAA MEKQRGSAEV SDSSNESEYF
160 170 180 190 200
SEQLAAEQFS QYAPTASPIP PAATTLHQQQ QQLQHQQQQQ YQQHQQQLQQ
210 220 230 240 250
QQHQHQHYLQ QQQQTLPPPP IQHQQYNTAA ITPTYQQLQQ QQQQQQQQRA
260 270 280 290 300
QQQQLHDPYA HYQQPQALRQ QQQQQQQQQQ QLLQQQAIKQ ASHLYPTATS
310 320 330 340 350
QQQQMPPPQS PANPQQQALN SYNEMRSAIL QNSHHPSGNS VDQYDQPQQQ
360 370 380 390 400
QHQPQQQSTN PTLVAAQQQQ SHHSLLNNNA SNGGISHSHH SNINNNGHGS
410 420 430 440 450
QNQMLPPQMR RSAASVVAYD GNSKQQVAAG PGAAQNHLQQ LYASPNYAAV
460 470 480 490 500
TPSENSINVK QHASNGHMPN QQQQHVAGGS NIGKIADYDP LTDGPRVVPN
510 520 530 540 550
AGRSSTTLVY SSEPRGNQGG NSVYPKRIGS VSDIDPANGI YGSLTAAEQA
560 570 580 590 600
HQQQKHQQYY QQVQMMQQQE HPPQQQQMRQ QPSYSSLQEK QSRQSTAMRV
610 620 630 640 650
YRAIYDYEAQ DVDEVSFREG DVIFEVESID SGWMTGRVER TGKTGMLPAN

YVEQAVI
Length:657
Mass (Da):74,247
Last modified:January 4, 2005 - v2
Checksum:i9383E1DEFBF6B529
GO
Isoform B1 Publication (identifier: Q8I7C3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-145: N → T
     146-298: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:504
Mass (Da):55,985
Checksum:iED4F389A19BE8AE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190Q → QQQQ (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051636145N → T in isoform B. 2 Publications1
Alternative sequenceiVSP_051637146 – 298Missing in isoform B. 2 PublicationsAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294538 mRNA Translation: CAC82378.1
AE014296 Genomic DNA Translation: AAF49426.3
AE014296 Genomic DNA Translation: AAN11739.2
BT003801 mRNA Translation: AAO41484.1
RefSeqiNP_648912.2, NM_140655.3 [Q8I7C3-2]
NP_730192.2, NM_168681.4 [Q8I7C3-1]
UniGeneiDm.15215

Genome annotation databases

EnsemblMetazoaiFBtr0075350; FBpp0075109; FBgn0063485 [Q8I7C3-2]
FBtr0100145; FBpp0099495; FBgn0063485 [Q8I7C3-1]
GeneIDi39864
KEGGidme:Dmel_CG3849

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLASP1_DROME
AccessioniPrimary (citable) accession number: Q8I7C3
Secondary accession number(s): Q59E31, Q9VV91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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