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Protein
Submitted name:

2-oxoglutarate dehydrogenase E1 component

Gene

PF08_0045

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GO_Central
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: GeneDB_Pfalciparum
  2. tricarboxylic acid cycle Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase E1 componentImported (EC:1.2.4.2Imported)
Gene namesi
ORF Names:PF08_0045Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 8

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0820700.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: GeneDB_Pfalciparum
  2. oxoglutarate dehydrogenase complex Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8I6S5.

Interactioni

Protein-protein interaction databases

IntActiQ8I6S5. 2 interactions.
MINTiMINT-1673189.
STRINGi5833.PF08_0045-1.

Structurei

3D structure databases

ProteinModelPortaliQ8I6S5.
SMRiQ8I6S5. Positions 126-1024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000259586.
InParanoidiQ8I6S5.
KOiK00164.
OMAiFVIHKGI.
PhylomeDBiQ8I6S5.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I6S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKFFYTNNL VRNNGKDIRT RSFHLSSCLY DYNFNPSMTS YIENTYKIWK
60 70 80 90 100
EDRNNLHKSW DSLFSMYPHA EMDNYNNPIK INRKTDNYNN SNCFQDVLKN
110 120 130 140 150
NNLRITYVNN EMLEKGKTEN IYDLARIVQL IRWYQKKGHL YANINPLPLP
160 170 180 190 200
KEPPYSSVCY EPCKRKMSYV DFGFNEDDLD KEFFFDLPSI SGFSSNGMKK
210 220 230 240 250
CNLRNLLKRL EETYCGTIGF EYMHITNENI VNYIIQRIEK DKKYEYDTKM
260 270 280 290 300
KKRILEYTAR AFIFENYMAA KFATTKRFGV DGCETLITGM KALIKRAAQL
310 320 330 340 350
DVDSVLMSMS HRGRLNVLFN VLHKPLEQMM SEFRGKTGFS DNIWGNTGDV
360 370 380 390 400
KYHLGVEIDY YDEDSQRYIH MGIVDNSSHL ESVDPILMGQ ARAQQYYCND
410 420 430 440 450
KEKKKVLPIT IHGDASIAGQ GIAYETFQMS KLPSYNVGGT IHIVVNNQIG
460 470 480 490 500
FTTYPIDARS GKYCTDIAKC IDIPIIHVNA DDPEAVTYVF ELALDIRNKF
510 520 530 540 550
NIDTIIDIVG YRRFGHNELD MPKFTNPLLY DVIARHKSVL DIYSKKLIDE
560 570 580 590 600
NIISLKEFED NKTEIFNFYE QVYEKSKSFV PTPKEKYLPQ WEHMVTPQKF
610 620 630 640 650
SPSRKTGVEK DVLINLGKKI FTLRENFTAH PIITKLFKSR IDSLETGKNI
660 670 680 690 700
DFGTAELLAY ATLLSDGFHA RLSGQDSQRG TFSHRHAVLH DQITYESYNI
710 720 730 740 750
FDSLKTPHTI EVNNSLLSEY ACLGYEIGYS YEHPDALVIW EAQFGDFANG
760 770 780 790 800
AQVMIDNYIA SGETKWNKQS GIVMLLPHGY DGQGPEHSSA RIERFLQLCD
810 820 830 840 850
DREDIATYSV EKDNKIIQQH NMQVINCSKP SNFFHALRRQ MHRSFRKPLI
860 870 880 890 900
VITPKKMLKM RMAFDKIENF LTNTEFLPYL PEEVGHKLKD KKEIKRIILC
910 920 930 940 950
SGQVYYDLLN YRYTNKIDDV AIARIEQLSP FPFKQIMNDL QTYPNLRDII
960 970 980 990 1000
WAQEEHMNMG PWFYVSRRIE ASIKQLKKDK PKWNIQIPQV RYSGRDVYAA
1010 1020 1030
QSAGDLNLHL YQLDEFLVDA FNLDKKYNMH VQKYTDAL
Length:1,038
Mass (Da):121,150
Last modified:March 1, 2003 - v1
Checksum:i8359B70B2C2F2A36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844507 Genomic DNA. Translation: CAD51167.1.
RefSeqiXP_001349318.1. XM_001349282.1.

Genome annotation databases

EnsemblProtistsiPF08_0045:mRNA; PF08_0045:pep; PF08_0045.
GeneIDi2655496.
KEGGipfa:PF08_0045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844507 Genomic DNA. Translation: CAD51167.1.
RefSeqiXP_001349318.1. XM_001349282.1.

3D structure databases

ProteinModelPortaliQ8I6S5.
SMRiQ8I6S5. Positions 126-1024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8I6S5. 2 interactions.
MINTiMINT-1673189.
STRINGi5833.PF08_0045-1.

Proteomic databases

PRIDEiQ8I6S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPF08_0045:mRNA; PF08_0045:pep; PF08_0045.
GeneIDi2655496.
KEGGipfa:PF08_0045.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0820700.

Phylogenomic databases

HOGENOMiHOG000259586.
InParanoidiQ8I6S5.
KOiK00164.
OMAiFVIHKGI.
PhylomeDBiQ8I6S5.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.

Entry informationi

Entry nameiQ8I6S5_PLAF7
AccessioniPrimary (citable) accession number: Q8I6S5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.