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Q8I6S5

- Q8I6S5_PLAF7

UniProt

Q8I6S5 - Q8I6S5_PLAF7

Protein
Submitted name:

2-oxoglutarate dehydrogenase E1 component

Gene

PF08_0045

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GeneDB_Pfalciparum
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: GeneDB_Pfalciparum
    2. tricarboxylic acid cycle Source: GeneDB_Pfalciparum

    Keywords - Molecular functioni

    OxidoreductaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-oxoglutarate dehydrogenase E1 componentImported (EC:1.2.4.2Imported)
    Gene namesi
    ORF Names:PF08_0045Imported
    OrganismiPlasmodium falciparum (isolate 3D7)Imported
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 8

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_0820700.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: GeneDB_Pfalciparum

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8I6S5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8I6S5. 2 interactions.
    MINTiMINT-1673189.
    STRINGi5833.PF08_0045-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8I6S5.
    SMRiQ8I6S5. Positions 126-1024.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000259586.
    KOiK00164.
    OMAiGFTTAPH.
    PhylomeDBiQ8I6S5.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8I6S5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKFFYTNNL VRNNGKDIRT RSFHLSSCLY DYNFNPSMTS YIENTYKIWK     50
    EDRNNLHKSW DSLFSMYPHA EMDNYNNPIK INRKTDNYNN SNCFQDVLKN 100
    NNLRITYVNN EMLEKGKTEN IYDLARIVQL IRWYQKKGHL YANINPLPLP 150
    KEPPYSSVCY EPCKRKMSYV DFGFNEDDLD KEFFFDLPSI SGFSSNGMKK 200
    CNLRNLLKRL EETYCGTIGF EYMHITNENI VNYIIQRIEK DKKYEYDTKM 250
    KKRILEYTAR AFIFENYMAA KFATTKRFGV DGCETLITGM KALIKRAAQL 300
    DVDSVLMSMS HRGRLNVLFN VLHKPLEQMM SEFRGKTGFS DNIWGNTGDV 350
    KYHLGVEIDY YDEDSQRYIH MGIVDNSSHL ESVDPILMGQ ARAQQYYCND 400
    KEKKKVLPIT IHGDASIAGQ GIAYETFQMS KLPSYNVGGT IHIVVNNQIG 450
    FTTYPIDARS GKYCTDIAKC IDIPIIHVNA DDPEAVTYVF ELALDIRNKF 500
    NIDTIIDIVG YRRFGHNELD MPKFTNPLLY DVIARHKSVL DIYSKKLIDE 550
    NIISLKEFED NKTEIFNFYE QVYEKSKSFV PTPKEKYLPQ WEHMVTPQKF 600
    SPSRKTGVEK DVLINLGKKI FTLRENFTAH PIITKLFKSR IDSLETGKNI 650
    DFGTAELLAY ATLLSDGFHA RLSGQDSQRG TFSHRHAVLH DQITYESYNI 700
    FDSLKTPHTI EVNNSLLSEY ACLGYEIGYS YEHPDALVIW EAQFGDFANG 750
    AQVMIDNYIA SGETKWNKQS GIVMLLPHGY DGQGPEHSSA RIERFLQLCD 800
    DREDIATYSV EKDNKIIQQH NMQVINCSKP SNFFHALRRQ MHRSFRKPLI 850
    VITPKKMLKM RMAFDKIENF LTNTEFLPYL PEEVGHKLKD KKEIKRIILC 900
    SGQVYYDLLN YRYTNKIDDV AIARIEQLSP FPFKQIMNDL QTYPNLRDII 950
    WAQEEHMNMG PWFYVSRRIE ASIKQLKKDK PKWNIQIPQV RYSGRDVYAA 1000
    QSAGDLNLHL YQLDEFLVDA FNLDKKYNMH VQKYTDAL 1038
    Length:1,038
    Mass (Da):121,150
    Last modified:March 1, 2003 - v1
    Checksum:i8359B70B2C2F2A36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844507 Genomic DNA. Translation: CAD51167.1.
    RefSeqiXP_001349318.1. XM_001349282.1.

    Genome annotation databases

    EnsemblProtistsiPF08_0045:mRNA; PF08_0045:pep; PF08_0045.
    GeneIDi2655496.
    KEGGipfa:PF08_0045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844507 Genomic DNA. Translation: CAD51167.1 .
    RefSeqi XP_001349318.1. XM_001349282.1.

    3D structure databases

    ProteinModelPortali Q8I6S5.
    SMRi Q8I6S5. Positions 126-1024.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8I6S5. 2 interactions.
    MINTi MINT-1673189.
    STRINGi 5833.PF08_0045-1.

    Proteomic databases

    PRIDEi Q8I6S5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PF08_0045:mRNA ; PF08_0045:pep ; PF08_0045 .
    GeneIDi 2655496.
    KEGGi pfa:PF08_0045.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_0820700.

    Phylogenomic databases

    HOGENOMi HOG000259586.
    KOi K00164.
    OMAi GFTTAPH.
    PhylomeDBi Q8I6S5.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
      Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
      , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
      Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.

    Entry informationi

    Entry nameiQ8I6S5_PLAF7
    AccessioniPrimary (citable) accession number: Q8I6S5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3