Q8I6S5 (Q8I6S5_PLAF7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
2-oxoglutarate dehydrogenase E1 component EMBL CAD51167.1
EC=1.2.4.2 EMBL CAD51167.1

Gene names

ORF Names:

PF08_0045 EMBL CAD51167.1

Organism

Plasmodium falciparum (isolate 3D7) [Reference proteome]

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum

Protein attributes

Sequence length	1038 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Molecular function	Oxidoreductase EMBL CAD51167.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	2-oxoglutarate metabolic process Inferred from sequence or structural similarity Ref.2. Source: GeneDB_Pfalciparum tricarboxylic acid cycle Inferred from sequence or structural similarity Ref.2. Source: GeneDB_Pfalciparum
Cellular_component	mitochondrial matrix Inferred from sequence or structural similarity Ref.2. Source: GeneDB_Pfalciparum
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8I6S5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 8359B70B2C2F2A36	FASTA	1,038	121,150
	10 20 30 40 50 60 MRKFFYTNNL VRNNGKDIRT RSFHLSSCLY DYNFNPSMTS YIENTYKIWK EDRNNLHKSW 70 80 90 100 110 120 DSLFSMYPHA EMDNYNNPIK INRKTDNYNN SNCFQDVLKN NNLRITYVNN EMLEKGKTEN 130 140 150 160 170 180 IYDLARIVQL IRWYQKKGHL YANINPLPLP KEPPYSSVCY EPCKRKMSYV DFGFNEDDLD 190 200 210 220 230 240 KEFFFDLPSI SGFSSNGMKK CNLRNLLKRL EETYCGTIGF EYMHITNENI VNYIIQRIEK 250 260 270 280 290 300 DKKYEYDTKM KKRILEYTAR AFIFENYMAA KFATTKRFGV DGCETLITGM KALIKRAAQL 310 320 330 340 350 360 DVDSVLMSMS HRGRLNVLFN VLHKPLEQMM SEFRGKTGFS DNIWGNTGDV KYHLGVEIDY 370 380 390 400 410 420 YDEDSQRYIH MGIVDNSSHL ESVDPILMGQ ARAQQYYCND KEKKKVLPIT IHGDASIAGQ 430 440 450 460 470 480 GIAYETFQMS KLPSYNVGGT IHIVVNNQIG FTTYPIDARS GKYCTDIAKC IDIPIIHVNA 490 500 510 520 530 540 DDPEAVTYVF ELALDIRNKF NIDTIIDIVG YRRFGHNELD MPKFTNPLLY DVIARHKSVL 550 560 570 580 590 600 DIYSKKLIDE NIISLKEFED NKTEIFNFYE QVYEKSKSFV PTPKEKYLPQ WEHMVTPQKF 610 620 630 640 650 660 SPSRKTGVEK DVLINLGKKI FTLRENFTAH PIITKLFKSR IDSLETGKNI DFGTAELLAY 670 680 690 700 710 720 ATLLSDGFHA RLSGQDSQRG TFSHRHAVLH DQITYESYNI FDSLKTPHTI EVNNSLLSEY 730 740 750 760 770 780 ACLGYEIGYS YEHPDALVIW EAQFGDFANG AQVMIDNYIA SGETKWNKQS GIVMLLPHGY 790 800 810 820 830 840 DGQGPEHSSA RIERFLQLCD DREDIATYSV EKDNKIIQQH NMQVINCSKP SNFFHALRRQ 850 860 870 880 890 900 MHRSFRKPLI VITPKKMLKM RMAFDKIENF LTNTEFLPYL PEEVGHKLKD KKEIKRIILC 910 920 930 940 950 960 SGQVYYDLLN YRYTNKIDDV AIARIEQLSP FPFKQIMNDL QTYPNLRDII WAQEEHMNMG 970 980 990 1000 1010 1020 PWFYVSRRIE ASIKQLKKDK PKWNIQIPQV RYSGRDVYAA QSAGDLNLHL YQLDEFLVDA 1030 FNLDKKYNMH VQKYTDAL

References

[1]	"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[2]	"Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13." Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z. , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G. Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL844507 Genomic DNA. Translation: CAD51167.1.
RefSeq	XP_001349318.1. XM_001349282.1.
3D structure databases
ProteinModelPortal	Q8I6S5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8I6S5. 2 interactions.
MINT	MINT-1673189.
STRING	5833.PF08_0045-1.
Proteomic databases
PRIDE	Q8I6S5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	PF08_0045:mRNA; PF08_0045:pep; PF08_0045.
GeneID	2655496.
KEGG	pfa:PF08_0045.
Organism-specific databases
EuPathDB	PlasmoDB:PF3D7_0820700.
Phylogenomic databases
HOGENOM	HOG000259586.
KO	K00164.
OMA	CNEDQRY.
ProtClustDB	CLSZ2433065.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8I6S5_PLAF7

Accession

Primary (citable) accession number: Q8I6S5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)