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Protein

Conotoxin Vx2

Gene
N/A
Organism
Conus vexillum (Flag cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Elicits a series of symptoms, such as being sedative, tail stiffening and twisted jumping, when injected intracranially into mice. May not target potassium nor sodium channels of locust DUM neuron.

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Vx2
OrganismiConus vexillum (Flag cone)
Taxonomic identifieri89431 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri823. VxII precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000024980321 – 471 PublicationAdd BLAST27
PeptideiPRO_000024980448 – 68Conotoxin Vx2Add BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 68By similarity
Disulfide bondi56 ↔ 61By similarity
Disulfide bondi57 ↔ 65By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is II (CCC-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin M superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8I6R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSKLGVLVT ICLLLFPLTA LPLDGDQPAD HPAKRTQDHN LASPISAWID
60
PSHYCCCGGG CTDDCVNC
Length:68
Mass (Da):7,244
Last modified:March 1, 2003 - v1
Checksum:i0B61EEB2AAD38FD8
GO

Mass spectrometryi

Molecular mass is 2243.70 Da from positions 48 - 68. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161317 mRNA. Translation: AAN78279.1.

Similar proteinsi

Entry informationi

Entry nameiC2_CONVX
AccessioniPrimary (citable) accession number: Q8I6R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families