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Q8I6L9

- Q8I6L9_TRYCR

UniProt

Q8I6L9 - Q8I6L9_TRYCR

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Protein
Submitted name: Prostaglandin F2a synthase
Gene
TcPGFS
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611FMN; via amide nitrogenImported
Binding sitei71 – 711p-hydroxybenzaldehydeImported
Binding sitei103 – 1031FMNImported
Binding sitei195 – 1951FMNImported
Binding sitei249 – 2491FMNImported
Binding sitei364 – 3641p-hydroxybenzaldehydeImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 283FMNImported
Nucleotide bindingi313 – 3153FMNImported
Nucleotide bindingi336 – 3372FMNImported

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Flavoprotein, FMNImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin F2a synthaseImported
Gene namesi
Name:TcPGFSImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ATYX-ray1.70A/B1-379[»]
3ATZX-ray2.04A/B/C/D1-379[»]
ProteinModelPortaliQ8I6L9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni195 – 1984p-hydroxybenzaldehyde bindingImported

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I6L9-1 [UniParc]FASTAAdd to Basket

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MATFPELLRP LKLGRYTLRN RIIMAPLTRC QATEDDHVPR TESMLKYYED    50
RASAGLIIAE ATMVQPNYTG FLTEPGIYSD AQIEEWRKIV DAVHKKGGLI 100
FLQLIHAGRA GIPEKILQQS KSDQDPLAGR LLAASAIPIK DHRIPAYFAA 150
SGEKETYGVP EELTDDEVRD GIIPLFVEGA KNAIFKAGFD GVEIHGANGY 200
LLDAFFRESS NKRQSGPYAG TTIDTRCQLI YDVTKSVCDA VGSDRVGLRI 250
SPLNGVHGMI DSNPEALTKH LCKKIEPLSL AYLHYLRGDM VNQQIGDVVA 300
WVRGSYSGVK ISNLRYDFEE ADQQIREGKV DAVAFGAKFI ANPDLVERAQ 350
QNWPLNEPRP ETYYTRTAVG YNDYPTYNK 379
Length:379
Mass (Da):42,261
Last modified:March 1, 2003 - v1
Checksum:i4EEC57419ACAF8CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075599 mRNA. Translation: BAC24024.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075599 mRNA. Translation: BAC24024.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ATY X-ray 1.70 A/B 1-379 [» ]
3ATZ X-ray 2.04 A/B/C/D 1-379 [» ]
ProteinModelPortali Q8I6L9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view ]
Pfami PF00724. Oxidored_FMN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural insight into the stereoselective production of PGF2? by Old Yellow Enzyme from Trypanosoma cruzi."
    Okamoto N., Yamaguchi K., Mizohata E., Tokuoka K., Uchiyama N., Sugiyama S., Matsumura H., Inaka K., Urade Y., Inoue T.
    J. Biochem. 150:563-568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH FMN AND P-HYDROXYBENZALDEHYDE.

Entry informationi

Entry nameiQ8I6L9_TRYCR
AccessioniPrimary (citable) accession number: Q8I6L9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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