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Protein
Submitted name:

Prostaglandin F2a synthase

Gene

TcPGFS

Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611FMN; via amide nitrogenCombined sources
Binding sitei103 – 1031FMNCombined sources
Binding sitei195 – 1951FMNCombined sources
Binding sitei249 – 2491FMNCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 283FMNCombined sources
Nucleotide bindingi313 – 3153FMNCombined sources
Nucleotide bindingi336 – 3372FMNCombined sources

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Flavoprotein, FMNCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin F2a synthaseImported
Gene namesi
Name:TcPGFSImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ATYX-ray1.70A/B1-379[»]
3ATZX-ray2.04A/B/C/D1-379[»]
ProteinModelPortaliQ8I6L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I6L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFPELLRP LKLGRYTLRN RIIMAPLTRC QATEDDHVPR TESMLKYYED
60 70 80 90 100
RASAGLIIAE ATMVQPNYTG FLTEPGIYSD AQIEEWRKIV DAVHKKGGLI
110 120 130 140 150
FLQLIHAGRA GIPEKILQQS KSDQDPLAGR LLAASAIPIK DHRIPAYFAA
160 170 180 190 200
SGEKETYGVP EELTDDEVRD GIIPLFVEGA KNAIFKAGFD GVEIHGANGY
210 220 230 240 250
LLDAFFRESS NKRQSGPYAG TTIDTRCQLI YDVTKSVCDA VGSDRVGLRI
260 270 280 290 300
SPLNGVHGMI DSNPEALTKH LCKKIEPLSL AYLHYLRGDM VNQQIGDVVA
310 320 330 340 350
WVRGSYSGVK ISNLRYDFEE ADQQIREGKV DAVAFGAKFI ANPDLVERAQ
360 370
QNWPLNEPRP ETYYTRTAVG YNDYPTYNK
Length:379
Mass (Da):42,261
Last modified:March 1, 2003 - v1
Checksum:i4EEC57419ACAF8CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075599 mRNA. Translation: BAC24024.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075599 mRNA. Translation: BAC24024.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ATYX-ray1.70A/B1-379[»]
3ATZX-ray2.04A/B/C/D1-379[»]
ProteinModelPortaliQ8I6L9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi."
    Okamoto N., Yamaguchi K., Mizohata E., Tokuoka K., Uchiyama N., Sugiyama S., Matsumura H., Inaka K., Urade Y., Inoue T.
    J. Biochem. 150:563-568(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH FMN.

Entry informationi

Entry nameiQ8I6L9_TRYCR
AccessioniPrimary (citable) accession number: Q8I6L9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.