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Q8I6L9

- Q8I6L9_TRYCR

UniProt

Q8I6L9 - Q8I6L9_TRYCR

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Protein
Submitted name:

Prostaglandin F2a synthase

Gene

TcPGFS

Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611FMN; via amide nitrogenImported
Binding sitei103 – 1031FMNImported
Binding sitei195 – 1951FMNImported
Binding sitei249 – 2491FMNImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 283FMNImported
Nucleotide bindingi313 – 3153FMNImported
Nucleotide bindingi336 – 3372FMNImported

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Flavoprotein, FMNImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin F2a synthaseImported
Gene namesi
Name:TcPGFSImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ATYX-ray1.70A/B1-379[»]
3ATZX-ray2.04A/B/C/D1-379[»]
ProteinModelPortaliQ8I6L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I6L9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATFPELLRP LKLGRYTLRN RIIMAPLTRC QATEDDHVPR TESMLKYYED
60 70 80 90 100
RASAGLIIAE ATMVQPNYTG FLTEPGIYSD AQIEEWRKIV DAVHKKGGLI
110 120 130 140 150
FLQLIHAGRA GIPEKILQQS KSDQDPLAGR LLAASAIPIK DHRIPAYFAA
160 170 180 190 200
SGEKETYGVP EELTDDEVRD GIIPLFVEGA KNAIFKAGFD GVEIHGANGY
210 220 230 240 250
LLDAFFRESS NKRQSGPYAG TTIDTRCQLI YDVTKSVCDA VGSDRVGLRI
260 270 280 290 300
SPLNGVHGMI DSNPEALTKH LCKKIEPLSL AYLHYLRGDM VNQQIGDVVA
310 320 330 340 350
WVRGSYSGVK ISNLRYDFEE ADQQIREGKV DAVAFGAKFI ANPDLVERAQ
360 370
QNWPLNEPRP ETYYTRTAVG YNDYPTYNK
Length:379
Mass (Da):42,261
Last modified:March 1, 2003 - v1
Checksum:i4EEC57419ACAF8CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075599 mRNA. Translation: BAC24024.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075599 mRNA. Translation: BAC24024.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ATY X-ray 1.70 A/B 1-379 [» ]
3ATZ X-ray 2.04 A/B/C/D 1-379 [» ]
ProteinModelPortali Q8I6L9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view ]
Pfami PF00724. Oxidored_FMN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural insight into the stereoselective production of PGF2? by Old Yellow Enzyme from Trypanosoma cruzi."
    Okamoto N., Yamaguchi K., Mizohata E., Tokuoka K., Uchiyama N., Sugiyama S., Matsumura H., Inaka K., Urade Y., Inoue T.
    J. Biochem. 150:563-568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH FMN.

Entry informationi

Entry nameiQ8I6L9_TRYCR
AccessioniPrimary (citable) accession number: Q8I6L9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3