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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

PFL0630w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • [3Fe-4S] clusterUniRule annotationNote: Binds 1 [3Fe-4S] cluster.UniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: GeneDB_Pfalciparum
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  7. succinate dehydrogenase activity Source: GeneDB_Pfalciparum

GO - Biological processi

  1. oxidation-reduction process Source: GeneDB_Pfalciparum
  2. tricarboxylic acid cycle Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Ligandi

2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:PFL0630wImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1212800.

Subcellular locationi

Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. mitochondrion Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

IntActiQ8I5S5. 1 interaction.
MINTiMINT-1741055.
STRINGi5833.PFL0630w-1.

Structurei

3D structure databases

ProteinModelPortaliQ8I5S5.
SMRiQ8I5S5. Positions 66-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation
Contains 1 2Fe-2S ferredoxin-type domain.UniRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000160590.
InParanoidiQ8I5S5.
KOiK00235.
OMAiTFRVHRF.
PhylomeDBiQ8I5S5.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I5S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKYELKGV MNILNKKLCN NKSRNDIIQA YTYIQKRFNN GSINKEFEMK
60 70 80 90 100
KQVEQINKVN GEVVKRKKKF SIFRYNPTNK KRPQMETFEV DIDNCGPMVL
110 120 130 140 150
DVLIKIKDEI DSTLSFRRSC REGICGSCAM NINGKNGLAC LTEVNRDKKE
160 170 180 190 200
ITEIQPLPNL YVMKDLVPDL TNFYNQYKSI DPWLKRKTKK EKGQKEFYQS
210 220 230 240 250
IEDRKKLDGL YECIMCASCS TSCPSYWWNP EYYLGPATLM QAYRWIVDSR
260 270 280 290 300
DEYTKERLME VNDTMKLYRC HGIMNCTMCC PKGLDPAKAI KDMKNLVQEN
310 320
FSEDTIKEHS QYIKSKMEKT K
Length:321
Mass (Da):37,752
Last modified:March 1, 2003 - v1
Checksum:i6E132848351F4235
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014846 Genomic DNA. Translation: AAN36215.1.
RefSeqiXP_001350535.1. XM_001350499.1.

Genome annotation databases

EnsemblProtistsiPFL0630w:mRNA; PFL0630w:pep; PFL0630w.
GeneIDi811179.
KEGGipfa:PFL0630w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014846 Genomic DNA. Translation: AAN36215.1.
RefSeqiXP_001350535.1. XM_001350499.1.

3D structure databases

ProteinModelPortaliQ8I5S5.
SMRiQ8I5S5. Positions 66-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8I5S5. 1 interaction.
MINTiMINT-1741055.
STRINGi5833.PFL0630w-1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPFL0630w:mRNA; PFL0630w:pep; PFL0630w.
GeneIDi811179.
KEGGipfa:PFL0630w.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1212800.

Phylogenomic databases

HOGENOMiHOG000160590.
InParanoidiQ8I5S5.
KOiK00235.
OMAiTFRVHRF.
PhylomeDBiQ8I5S5.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.

Entry informationi

Entry nameiQ8I5S5_PLAF7
AccessioniPrimary (citable) accession number: Q8I5S5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.