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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

PFL0780w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181Proton acceptorUniRule annotation

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: GeneDB_Pfalciparum
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
  3. glycerol-3-phosphate metabolic process Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
ORF Names:PFL0780wImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1216200.

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: GeneDB_Pfalciparum
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8I5P5.

Interactioni

Protein-protein interaction databases

STRINGi5833.PFL0780w-1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YJ8X-ray2.85A/B/C1-367[»]
ProteinModelPortaliQ8I5P5.
SMRiQ8I5P5. Positions 2-364.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8I5P5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 2832Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246855.
InParanoidiQ8I5P5.
KOiK00006.
OMAiFETPYFR.
PhylomeDBiQ8I5P5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I5P5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRNLFDKLK DGPLKISILG SGNWASAISK VVGTNAKNNY LFENEVRMWI
60 70 80 90 100
RDEFVNGERM VDIINNKHEN TKYLKGVPLP HNIVAHSDLA SVINDADLLI
110 120 130 140 150
FIVPCQYLES VLASIKESES IKIASHAKAI SLTKGFIVKK NQMKLCSNYI
160 170 180 190 200
SDFLNIPCSA LSGANIAMDV AMENFSEATI GGNDKDSLVI WQRVFDLPYF
210 220 230 240 250
KINCVNETIE VEICGALKNI ITLACGFCDG LNLPTNSKSA IIRNGINEMI
260 270 280 290 300
LFGKVFFQKF NENILLESCG FADIITSFLA GRNAKCSAEF IKSTPKKTWE
310 320 330 340 350
ELENEILKGQ KLQGTVTLKY VYHMIKEKNM TNEFPLFTVL HKISFENEDP
360
SSLLKTFMNN KINQLNL
Length:367
Mass (Da):41,234
Last modified:March 1, 2003 - v1
Checksum:i20936A730B93B907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014846 Genomic DNA. Translation: AAN36245.1.
RefSeqiXP_001350565.1. XM_001350529.2.

Genome annotation databases

EnsemblProtistsiPFL0780w:mRNA; PFL0780w:pep; PFL0780w.
GeneIDi811209.
KEGGipfa:PFL0780w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014846 Genomic DNA. Translation: AAN36245.1.
RefSeqiXP_001350565.1. XM_001350529.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YJ8X-ray2.85A/B/C1-367[»]
ProteinModelPortaliQ8I5P5.
SMRiQ8I5P5. Positions 2-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PFL0780w-1.

Proteomic databases

PRIDEiQ8I5P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPFL0780w:mRNA; PFL0780w:pep; PFL0780w.
GeneIDi811209.
KEGGipfa:PFL0780w.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1216200.

Phylogenomic databases

HOGENOMiHOG000246855.
InParanoidiQ8I5P5.
KOiK00006.
OMAiFETPYFR.
PhylomeDBiQ8I5P5.

Miscellaneous databases

EvolutionaryTraceiQ8I5P5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase."
    (SGPP), Structural Genomics of Pathogenic Protozoa
    Robien M.A., Hol W.G.J.
    Submitted (JAN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS).

Entry informationi

Entry nameiQ8I5P5_PLAF7
AccessioniPrimary (citable) accession number: Q8I5P5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.