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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

PF3D7_1216200

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134SubstrateUniRule annotation1
Binding sitei167NAD; via amide nitrogenUniRule annotation1
Active sitei218Proton acceptorUniRule annotation1
Binding sitei282NADUniRule annotation1
Binding sitei311NAD; via amide nitrogenUniRule annotation1
Binding sitei313NADUniRule annotation1

GO - Molecular functioni

  • glycerol-3-phosphate dehydrogenase [NAD+] activity Source: GeneDB
  • NAD binding Source: UniProtKB-UniRule
  • protein homodimerization activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-PFA-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
ORF Names:PF3D7_1216200Imported, PFL0780wImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1216200

Subcellular locationi

GO - Cellular componenti

  • glycerol-3-phosphate dehydrogenase complex Source: GeneDB

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YJ8X-ray2.85A/B/C1-367[»]
SMRiQ8I5P5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8I5P5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 186NAD_Gly3P_dh_NInterPro annotationAdd BLAST172
Domaini209 – 354NAD_Gly3P_dh_CInterPro annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni282 – 283Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246855
InParanoidiQ8I5P5
KOiK00006
OMAiMEMVAFA

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8I5P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRNLFDKLK DGPLKISILG SGNWASAISK VVGTNAKNNY LFENEVRMWI
60 70 80 90 100
RDEFVNGERM VDIINNKHEN TKYLKGVPLP HNIVAHSDLA SVINDADLLI
110 120 130 140 150
FIVPCQYLES VLASIKESES IKIASHAKAI SLTKGFIVKK NQMKLCSNYI
160 170 180 190 200
SDFLNIPCSA LSGANIAMDV AMENFSEATI GGNDKDSLVI WQRVFDLPYF
210 220 230 240 250
KINCVNETIE VEICGALKNI ITLACGFCDG LNLPTNSKSA IIRNGINEMI
260 270 280 290 300
LFGKVFFQKF NENILLESCG FADIITSFLA GRNAKCSAEF IKSTPKKTWE
310 320 330 340 350
ELENEILKGQ KLQGTVTLKY VYHMIKEKNM TNEFPLFTVL HKISFENEDP
360
SSLLKTFMNN KINQLNL
Length:367
Mass (Da):41,234
Last modified:March 1, 2003 - v1
Checksum:i20936A730B93B907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014846 Genomic DNA Translation: AAN36245.1
LN999947 Genomic DNA Translation: CZT99323.1
RefSeqiXP_001350565.1, XM_001350529.2

Genome annotation databases

EnsemblProtistsiCZT99323; CZT99323; PF3D7_1216200
GeneDBiPF3D7_1216200.1:pep
GeneIDi811209
KEGGipfa:PFL0780w

Similar proteinsi

Entry informationi

Entry nameiQ8I5P5_PLAF7
AccessioniPrimary (citable) accession number: Q8I5P5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health