Q8I5P5 (Q8I5P5_PLAF7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glycerol-3-phosphate dehydrogenase, putative EMBL AAN36245.1
EC=1.1.1.8 EMBL AAN36245.1

Gene names

ORF Names:

PFL0780w EMBL AAN36245.1

Organism

Plasmodium falciparum (isolate 3D7) [Reference proteome]

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. RuleBase RU000437

Ontologies

Keywords
Ligand	NAD RuleBase RU000437
Molecular function	Oxidoreductase RuleBase RU000437 EMBL AAN36245.1
Technical term	3D-structure PDB 1YJ8 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase [NAD+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8I5P5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 20936A730B93B907	FASTA	367	41,234
	10 20 30 40 50 60 MYRNLFDKLK DGPLKISILG SGNWASAISK VVGTNAKNNY LFENEVRMWI RDEFVNGERM 70 80 90 100 110 120 VDIINNKHEN TKYLKGVPLP HNIVAHSDLA SVINDADLLI FIVPCQYLES VLASIKESES 130 140 150 160 170 180 IKIASHAKAI SLTKGFIVKK NQMKLCSNYI SDFLNIPCSA LSGANIAMDV AMENFSEATI 190 200 210 220 230 240 GGNDKDSLVI WQRVFDLPYF KINCVNETIE VEICGALKNI ITLACGFCDG LNLPTNSKSA 250 260 270 280 290 300 IIRNGINEMI LFGKVFFQKF NENILLESCG FADIITSFLA GRNAKCSAEF IKSTPKKTWE 310 320 330 340 350 360 ELENEILKGQ KLQGTVTLKY VYHMIKEKNM TNEFPLFTVL HKISFENEDP SSLLKTFMNN KINQLNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[2]	"Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase." (SGPP), Structural Genomics of Pathogenic Protozoa Robien M.A., Hol W.G.J. Submitted (JAN-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE014188 Genomic DNA. Translation: AAN36245.1.

RefSeq

XP_001350565.1. XM_001350529.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YJ8	X-ray	2.85	A/B/C	1-367	[»]

ProteinModelPortal

Q8I5P5.

SMR

Q8I5P5. Positions 2-364.

ModBase

Search...

Protein-protein interaction databases

STRING

5833.PFL0780w-1.

Proteomic databases

PRIDE

Q8I5P5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

PFL0780w:mRNA; PFL0780w:pep; PFL0780w.

GeneID

811209.

KEGG

pfa:PFL0780w.

Organism-specific databases

EuPathDB

PlasmoDB:PF3D7_1216200.

Phylogenomic databases

HOGENOM

HOG000246855.

KO

K00006.

OMA

VARNCNN.

ProtClustDB

PTZ00345.

Family and domain databases

Gene3D

1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.

InterPro

IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

PANTHER

PTHR11728. PTHR11728. 1 hit.

Pfam

PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000114. Glycerol-3-P_dh. 1 hit.

PRINTS

PR00077. GPDHDRGNASE.

SUPFAM

SSF48179. 6DGDH_C_like. 1 hit.

TIGRFAMs

TIGR03376. glycerol3P_DH. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q8I5P5.

Entry information

Entry name

Q8I5P5_PLAF7

Accession

Primary (citable) accession number: Q8I5P5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)