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Q8I5P5

- Q8I5P5_PLAF7

UniProt

Q8I5P5 - Q8I5P5_PLAF7

Protein
Submitted name:

Glycerol-3-phosphate dehydrogenase, putative

Gene

PFL0780w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei134 – 1341Substrate
    Active sitei218 – 2181Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: GeneDB_Pfalciparum
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro
    3. glycerol-3-phosphate metabolic process Source: GeneDB_Pfalciparum

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    NADUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_217128. Synthesis of PA.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glycerol-3-phosphate dehydrogenase, putativeImported (EC:1.1.1.8Imported)
    Gene namesi
    ORF Names:PFL0780wImported
    OrganismiPlasmodium falciparum (isolate 3D7)Imported
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 12

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_1216200.

    Subcellular locationi

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: GeneDB_Pfalciparum

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8I5P5.

    Interactioni

    Protein-protein interaction databases

    STRINGi5833.PFL0780w-1.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YJ8X-ray2.85A/B/C1-367[»]
    ProteinModelPortaliQ8I5P5.
    SMRiQ8I5P5. Positions 2-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8I5P5.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni282 – 2832Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000246855.
    KOiK00006.
    OMAiEFVTCLQ.
    PhylomeDBiQ8I5P5.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8I5P5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYRNLFDKLK DGPLKISILG SGNWASAISK VVGTNAKNNY LFENEVRMWI    50
    RDEFVNGERM VDIINNKHEN TKYLKGVPLP HNIVAHSDLA SVINDADLLI 100
    FIVPCQYLES VLASIKESES IKIASHAKAI SLTKGFIVKK NQMKLCSNYI 150
    SDFLNIPCSA LSGANIAMDV AMENFSEATI GGNDKDSLVI WQRVFDLPYF 200
    KINCVNETIE VEICGALKNI ITLACGFCDG LNLPTNSKSA IIRNGINEMI 250
    LFGKVFFQKF NENILLESCG FADIITSFLA GRNAKCSAEF IKSTPKKTWE 300
    ELENEILKGQ KLQGTVTLKY VYHMIKEKNM TNEFPLFTVL HKISFENEDP 350
    SSLLKTFMNN KINQLNL 367
    Length:367
    Mass (Da):41,234
    Last modified:March 1, 2003 - v1
    Checksum:i20936A730B93B907
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014188 Genomic DNA. Translation: AAN36245.1.
    RefSeqiXP_001350565.1. XM_001350529.2.

    Genome annotation databases

    EnsemblProtistsiPFL0780w:mRNA; PFL0780w:pep; PFL0780w.
    GeneIDi811209.
    KEGGipfa:PFL0780w.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014188 Genomic DNA. Translation: AAN36245.1 .
    RefSeqi XP_001350565.1. XM_001350529.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YJ8 X-ray 2.85 A/B/C 1-367 [» ]
    ProteinModelPortali Q8I5P5.
    SMRi Q8I5P5. Positions 2-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5833.PFL0780w-1.

    Proteomic databases

    PRIDEi Q8I5P5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PFL0780w:mRNA ; PFL0780w:pep ; PFL0780w .
    GeneIDi 811209.
    KEGGi pfa:PFL0780w.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_1216200.

    Phylogenomic databases

    HOGENOMi HOG000246855.
    KOi K00006.
    OMAi EFVTCLQ.
    PhylomeDBi Q8I5P5.

    Enzyme and pathway databases

    Reactomei REACT_217128. Synthesis of PA.

    Miscellaneous databases

    EvolutionaryTracei Q8I5P5.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    2. "Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase."
      (SGPP), Structural Genomics of Pathogenic Protozoa
      Robien M.A., Hol W.G.J.
      Submitted (JAN-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS).

    Entry informationi

    Entry nameiQ8I5P5_PLAF7
    AccessioniPrimary (citable) accession number: Q8I5P5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3