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Q8I5P5

- Q8I5P5_PLAF7

UniProt

Q8I5P5 - Q8I5P5_PLAF7

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Protein
Submitted name: Glycerol-3-phosphate dehydrogenase, putative
Gene
PFL0780w
Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341Substrate By similarity
Active sitei218 – 2181Proton acceptor By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_217128. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Submitted name:
Glycerol-3-phosphate dehydrogenase, putativeImported (EC:1.1.1.8Imported)
Gene namesi
ORF Names:PFL0780wImported
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1216200.

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8I5P5.

Interactioni

Protein-protein interaction databases

STRINGi5833.PFL0780w-1.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YJ8X-ray2.85A/B/C1-367[»]
ProteinModelPortaliQ8I5P5.
SMRiQ8I5P5. Positions 2-364.

Miscellaneous databases

EvolutionaryTraceiQ8I5P5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 2832Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246855.
KOiK00006.
OMAiEFVTCLQ.
PhylomeDBiQ8I5P5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I5P5-1 [UniParc]FASTAAdd to Basket

« Hide

MYRNLFDKLK DGPLKISILG SGNWASAISK VVGTNAKNNY LFENEVRMWI    50
RDEFVNGERM VDIINNKHEN TKYLKGVPLP HNIVAHSDLA SVINDADLLI 100
FIVPCQYLES VLASIKESES IKIASHAKAI SLTKGFIVKK NQMKLCSNYI 150
SDFLNIPCSA LSGANIAMDV AMENFSEATI GGNDKDSLVI WQRVFDLPYF 200
KINCVNETIE VEICGALKNI ITLACGFCDG LNLPTNSKSA IIRNGINEMI 250
LFGKVFFQKF NENILLESCG FADIITSFLA GRNAKCSAEF IKSTPKKTWE 300
ELENEILKGQ KLQGTVTLKY VYHMIKEKNM TNEFPLFTVL HKISFENEDP 350
SSLLKTFMNN KINQLNL 367
Length:367
Mass (Da):41,234
Last modified:March 1, 2003 - v1
Checksum:i20936A730B93B907
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014188 Genomic DNA. Translation: AAN36245.1.
RefSeqiXP_001350565.1. XM_001350529.2.

Genome annotation databases

EnsemblProtistsiPFL0780w:mRNA; PFL0780w:pep; PFL0780w.
GeneIDi811209.
KEGGipfa:PFL0780w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014188 Genomic DNA. Translation: AAN36245.1 .
RefSeqi XP_001350565.1. XM_001350529.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YJ8 X-ray 2.85 A/B/C 1-367 [» ]
ProteinModelPortali Q8I5P5.
SMRi Q8I5P5. Positions 2-364.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5833.PFL0780w-1.

Proteomic databases

PRIDEi Q8I5P5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PFL0780w:mRNA ; PFL0780w:pep ; PFL0780w .
GeneIDi 811209.
KEGGi pfa:PFL0780w.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1216200.

Phylogenomic databases

HOGENOMi HOG000246855.
KOi K00006.
OMAi EFVTCLQ.
PhylomeDBi Q8I5P5.

Enzyme and pathway databases

Reactomei REACT_217128. Synthesis of PA.

Miscellaneous databases

EvolutionaryTracei Q8I5P5.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. "Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase."
    (SGPP), Structural Genomics of Pathogenic Protozoa
    Robien M.A., Hol W.G.J.
    Submitted (JAN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS).

Entry informationi

Entry nameiQ8I5P5_PLAF7
AccessioniPrimary (citable) accession number: Q8I5P5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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