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Protein

Ribulose-phosphate 3-epimerase

Gene

PFL0960w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Metal bindingi36 – 361Divalent metal cationUniRule annotation
Metal bindingi36 – 361Zinc; via tele nitrogenCombined sources
Active sitei38 – 381Proton acceptorUniRule annotation
Metal bindingi38 – 381Divalent metal cationUniRule annotation
Metal bindingi38 – 381ZincCombined sources
Metal bindingi70 – 701Divalent metal cationUniRule annotation
Metal bindingi70 – 701Zinc; via pros nitrogenCombined sources
Binding sitei70 – 701SubstrateUniRule annotation
Active sitei179 – 1791Proton donorUniRule annotation
Metal bindingi179 – 1791Divalent metal cationUniRule annotation
Metal bindingi179 – 1791ZincCombined sources
Binding sitei181 – 1811Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Keywords - Ligandi

CobaltUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotationCombined sources, ZincUniRule annotationCombined sources

Enzyme and pathway databases

ReactomeiR-PFA-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimeraseUniRule annotation (EC:5.1.3.1UniRule annotation)
Gene namesi
ORF Names:PFL0960wImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1219900.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8I5L3.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TQXX-ray2.00A/B1-227[»]
ProteinModelPortaliQ8I5L3.
SMRiQ8I5L3. Positions 4-224.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8I5L3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1534Substrate bindingUniRule annotation
Regioni201 – 2022Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribulose-phosphate 3-epimerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000259349.
InParanoidiQ8I5L3.
KOiK01783.
OMAiICQALKP.
PhylomeDBiQ8I5L3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I5L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLKAIIAP SVLASNISKL AEETQRMESL GAEWIHLDVM DMHFVPNLSF
60 70 80 90 100
GPPVINNLKK YTKSIFFDVH LMVEYPEKYV PLLKTSNQLT FHFEALNEDT
110 120 130 140 150
ERCIQLAKEI RDNNLWCGIS IKPKTDVQKL VPILDTNLIN TVLVMTVEPG
160 170 180 190 200
FGGQSFMHDM MGKVSFLRKK YKNLNIQVDG GLNIETTEIS ASHGANIIVA
210 220
GTSIFNAEDP KYVIDTMRVS VQKYLNN
Length:227
Mass (Da):25,549
Last modified:March 1, 2003 - v1
Checksum:i03AB21FB511E0C11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36278.1.
RefSeqiXP_001350598.1. XM_001350562.1.

Genome annotation databases

EnsemblProtistsiPFL0960w:mRNA; PFL0960w:pep; PFL0960w.
GeneDBiPF3D7_1219900.1:pep.
GeneIDi811244.
KEGGipfa:PFL0960w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36278.1.
RefSeqiXP_001350598.1. XM_001350562.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TQXX-ray2.00A/B1-227[»]
ProteinModelPortaliQ8I5L3.
SMRiQ8I5L3. Positions 4-224.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8I5L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPFL0960w:mRNA; PFL0960w:pep; PFL0960w.
GeneDBiPF3D7_1219900.1:pep.
GeneIDi811244.
KEGGipfa:PFL0960w.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1219900.

Phylogenomic databases

HOGENOMiHOG000259349.
InParanoidiQ8I5L3.
KOiK01783.
OMAiICQALKP.
PhylomeDBiQ8I5L3.

Enzyme and pathway databases

ReactomeiR-PFA-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

EvolutionaryTraceiQ8I5L3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ8I5L3_PLAF7
AccessioniPrimary (citable) accession number: Q8I5L3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.