Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

RAC-beta serine/threonine protein kinase

Gene

PF3D7_1246900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: GeneDB
  • calmodulin-dependent protein kinase activity Source: GeneDB
  • phosphatidylinositol binding Source: GeneDB
  • phospholipase binding Source: GeneDB
  • protein serine/threonine kinase activity Source: GeneDB

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein autophosphorylation Source: GeneDB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotationImported, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
RAC-beta serine/threonine protein kinaseImported (EC:2.7.11.1Imported)
Submitted name:
Rac-beta serine/threonine protein kinase, putativeImported
Gene namesi
ORF Names:PF3D7_1246900Imported, PFL2250cImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1246900.

Subcellular locationi

GO - Cellular componenti

  • apical complex Source: GeneDB
  • cytoplasm Source: GeneDB
  • nucleus Source: GO_Central

Interactioni

GO - Molecular functioni

  • phospholipase binding Source: GeneDB

Structurei

3D structure databases

SMRiQ8I4W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini403 – 660Protein kinaseInterPro annotationAdd BLAST258
Domaini661 – 735AGC-kinase C-terminalInterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili120 – 147Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000283555.
InParanoidiQ8I4W3.
KOiK08286.
OMAiNDICSEN.

Family and domain databases

InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I4W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHINFFKCF SERNREKNNI PSYTSDSTQQ QKKKKDYKKY FNFLITKKNK
60 70 80 90 100
RETHKSTNGE EDYEHILYKN KTNVNIKEDN LKKDFDEYKE KKVNINGNVN
110 120 130 140 150
NKKYSDKTTH INSVMTLEKN MILNNDNNTL NNNKKKKKKK KKKKKKSYSV
160 170 180 190 200
EGTKLLKIKE YKKRKFFKIH FFLNRKNKNN DKREDPSKNI HDKRDISLEK
210 220 230 240 250
NIINYNKYDM QFSFESVASN NINNNTHFKK DKKIINLKKY NNAHRDLYKN
260 270 280 290 300
NYTNVFLCKK SFSDDEYKNK NIINNDSPCK FQKQNYDSKS KQGIYKANYR
310 320 330 340 350
RFRDSCRQKL DLYKIHNRRN DVLFYGKGAL KEIKKSMFDE NKENAFYKDN
360 370 380 390 400
MANCALNNMD NKNRMENECL YKYDEKEEIG KKRLRNSMSL SYERKKRIRP
410 420 430 440 450
ESFNYLKVIG EGSYGKVMLV KHVQNKKLYA MKILRKENIL SRNQLEHTKV
460 470 480 490 500
ERNILKCVSH PFIVKMYYAF QTKQKLYFIL EYCPGGELFF HLSKLREFSE
510 520 530 540 550
ETAKFYSSEI ILALEYLHDL NIIYRDLKPE NVLLDELGHI RLTDFGLSKE
560 570 580 590 600
GITETNLTKS LCGTPEYLAP EIIEQKGHGK AVDWWSLGIM LYEMLTGELP
610 620 630 640 650
FNNTNRNVLF ESIKYQKLNY PKNLSPKAVD LLTKLFEKNP KKRLGSGGTD
660 670 680 690 700
AQEIKKHPFF KNINWNDVLY KKVKPPFKPK LFNQLDLQNF DKQFLNMPLK
710 720 730
YSDQHENTNI TFADPKNFVV QDFNYNYYEF SGQQK
Length:735
Mass (Da):87,909
Last modified:March 1, 2003 - v1
Checksum:iF7061F82DE89DD4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014851 Genomic DNA. Translation: AAN36534.1.
LN999947 Genomic DNA. Translation: CZT99623.1.
RefSeqiXP_001350854.1. XM_001350818.1.

Genome annotation databases

EnsemblProtistsiCZT99623; CZT99623; PF3D7_1246900.
GeneDBiPF3D7_1246900.1:pep.
GeneIDi811502.
KEGGipfa:PFL2250c.

Similar proteinsi

Entry informationi

Entry nameiQ8I4W3_PLAF7
AccessioniPrimary (citable) accession number: Q8I4W3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported