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Protein
Submitted name:

RAC-beta serine/threonine protein kinase

Gene

PF3D7_1246900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: GeneDB
  • calmodulin-dependent protein kinase activity Source: GeneDB
  • phosphatidylinositol binding Source: GeneDB
  • phospholipase binding Source: GeneDB
  • protein serine/threonine kinase activity Source: GeneDB

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein autophosphorylation Source: GeneDB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotationImported, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-6804757 Regulation of TP53 Degradation

Names & Taxonomyi

Protein namesi
Submitted name:
RAC-beta serine/threonine protein kinaseImported (EC:2.7.11.1Imported)
Gene namesi
ORF Names:PF3D7_1246900Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1246900

Subcellular locationi

GO - Cellular componenti

  • apical complex Source: GeneDB
  • cytoplasm Source: GeneDB
  • nucleus Source: GO_Central

Interactioni

GO - Molecular functioni

  • phospholipase binding Source: GeneDB

Family & Domainsi

Phylogenomic databases

KOiK08286
OMAiILKCVSH

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8I4W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHINFFKCF SERNREKNNI PSYTSDSTQQ QKKKKDYKKY FNFLITKKNK
60 70 80 90 100
RETHKSTNGE EDYEHILYKN KTNVNIKEDN LKKDFDEYKE KKVNINGNVN
110 120 130 140 150
NKKYSDKTTH INSVMTLEKN MILNNDNNTL NNNKKKKKKK KKKKKKSYSV
160 170 180 190 200
EGTKLLKIKE YKKRKFFKIH FFLNRKNKNN DKREDPSKNI HDKRDISLEK
210 220 230 240 250
NIINYNKYDM QFSFESVASN NINNNTHFKK DKKIINLKKY NNAHRDLYKN
260 270 280 290 300
NYTNVFLCKK SFSDDEYKNK NIINNDSPCK FQKQNYDSKS KQGIYKANYR
310 320 330 340 350
RFRDSCRQKL DLYKIHNRRN DVLFYGKGAL KEIKKSMFDE NKENAFYKDN
360 370 380 390 400
MANCALNNMD NKNRMENECL YKYDEKEEIG KKRLRNSMSL SYERKKRIRP
410 420 430 440 450
ESFNYLKVIG EGSYGKVMLV KHVQNKKLYA MKILRKENIL SRNQLEHTKV
460 470 480 490 500
ERNILKCVSH PFIVKMYYAF QTKQKLYFIL EYCPGGELFF HLSKLREFSE
510 520 530 540 550
ETAKFYSSEI ILALEYLHDL NIIYRDLKPE NVLLDELGHI RLTDFGLSKE
560 570 580 590 600
GITETNLTKS LCGTPEYLAP EIIEQKGHGK AVDWWSLGIM LYEMLTGELP
610 620 630 640 650
FNNTNRNVLF ESIKYQKLNY PKNLSPKAVD LLTKLFEKNP KKRLGSGGTD
660 670 680 690 700
AQEIKKHPFF KNINWNDVLY KKVKPPFKPK LFNQLDLQNF DKQFLNMPLK
710 720 730
YSDQHENTNI TFADPKNFVV QDFNYNYYEF SGQQK
Length:735
Mass (Da):87,909
Last modified:March 1, 2003 - v1
Checksum:iF7061F82DE89DD4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99623.1
RefSeqiXP_001350854.1, XM_001350818.1

Genome annotation databases

EnsemblProtistsiCZT99623; CZT99623; PF3D7_1246900
GeneDBiPF3D7_1246900.1:pep
GeneIDi811502
KEGGipfa:PFL2250c

Similar proteinsi

Entry informationi

Entry nameiQ8I4W3_PLAF7
AccessioniPrimary (citable) accession number: Q8I4W3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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