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Q8I4V8

- Q8I4V8_PLAF7

UniProt

Q8I4V8 - Q8I4V8_PLAF7

Protein
Submitted name:

FK506-binding protein (FKBP)-type peptidyl-propyl isomerase

Gene

FKBP35

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. FK506 binding Source: GeneDB_Pfalciparum
    2. peptidyl-prolyl cis-trans isomerase activity Source: GeneDB_Pfalciparum
    3. protein dimerization activity Source: GeneDB_Pfalciparum

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. negative regulation of protein phosphatase type 2B activity Source: GeneDB_Pfalciparum
    3. protein folding Source: GeneDB_Pfalciparum
    4. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    IsomeraseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    FK506-binding protein (FKBP)-type peptidyl-propyl isomeraseImported (EC:5.2.1.8Imported)
    Gene namesi
    Name:FKBP35Imported
    ORF Names:PFL2275cImported
    OrganismiPlasmodium falciparum (isolate 3D7)Imported
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 12

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_1247400.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: GeneDB_Pfalciparum
    2. endoplasmic reticulum membrane Source: RefGenome
    3. nucleus Source: GeneDB_Pfalciparum

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8I4V8.

    Interactioni

    Protein-protein interaction databases

    STRINGi5833.PFL2275c-1.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FBNX-ray1.63A/B128-304[»]
    2OFNNMR-A1-127[»]
    2VN1X-ray2.35A/B1-127[»]
    4J4NX-ray2.75A/B/C1-127[»]
    ProteinModelPortaliQ8I4V8.
    SMRiQ8I4V8. Positions 6-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8I4V8.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000283560.
    KOiK01802.
    OMAiMESATYK.
    PhylomeDBiQ8I4V8.

    Family and domain databases

    Gene3Di1.10.150.160. 1 hit.
    1.25.40.10. 1 hit.
    InterProiIPR023114. Elongated_TPR_rpt_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8I4V8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTEQEFEKV ELTADGGVIK TILKKGDEGE ENIPKKGNEV TVHYVGKLES    50
    TGKVFDSSFD RNVPFKFHLE QGEVIKGWDI CVSSMRKNEK CLVRIESMYG 100
    YGDEGCGESI PGNSVLLFEI ELLSFREAKK SIYDYTDEEK VQSAFDIKEE 150
    GNEFFKKNEI NEAIVKYKEA LDFFIHTEEW DDQILLDKKK NIEISCNLNL 200
    ATCYNKNKDY PKAIDHASKV LKIDKNNVKA LYKLGVANMY FGFLEEAKEN 250
    LYKAASLNPN NLDIRNSYEL CVNKLKEARK KDKLTFGGMF DKGPLYEEKK 300
    NSAN 304
    Length:304
    Mass (Da):34,827
    Last modified:March 1, 2003 - v1
    Checksum:i72DBA2427DDF50DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014188 Genomic DNA. Translation: AAN36539.1.
    RefSeqiXP_001350859.1. XM_001350823.1.

    Genome annotation databases

    EnsemblProtistsiPFL2275c:mRNA; PFL2275c:pep; PFL2275c.
    GeneIDi811507.
    KEGGipfa:PFL2275c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014188 Genomic DNA. Translation: AAN36539.1 .
    RefSeqi XP_001350859.1. XM_001350823.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FBN X-ray 1.63 A/B 128-304 [» ]
    2OFN NMR - A 1-127 [» ]
    2VN1 X-ray 2.35 A/B 1-127 [» ]
    4J4N X-ray 2.75 A/B/C 1-127 [» ]
    ProteinModelPortali Q8I4V8.
    SMRi Q8I4V8. Positions 6-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5833.PFL2275c-1.

    Proteomic databases

    PRIDEi Q8I4V8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PFL2275c:mRNA ; PFL2275c:pep ; PFL2275c .
    GeneIDi 811507.
    KEGGi pfa:PFL2275c.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_1247400.

    Phylogenomic databases

    HOGENOMi HOG000283560.
    KOi K01802.
    OMAi MESATYK.
    PhylomeDBi Q8I4V8.

    Miscellaneous databases

    EvolutionaryTracei Q8I4V8.

    Family and domain databases

    Gene3Di 1.10.150.160. 1 hit.
    1.25.40.10. 1 hit.
    InterProi IPR023114. Elongated_TPR_rpt_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    2. "Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506."
      Kotaka M., Ye H., Alag R., Hu G., Bozdech Z., Preiser P.R., Yoon H.S., Lescar J.
      Biochemistry 47:5951-5961(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-127.
    3. "Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35)."
      Kang C.B., Ye H., Yoon H.R., Yoon H.S.
      Proteins 70:300-302(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-127.
    4. "Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide."
      Alag R., Bharatham N., Dong A., Hills T., Harikishore A., Widjaja A.A., Shochat S.G., Hui R., Yoon H.S.
      Protein Sci. 18:2115-2124(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 128-304.
    5. "Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent."
      Harikishore A., Niang M., Rajan S., Preiser P.R., Yoon H.S.
      Sci. Rep. 3:2501-2501(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1-127.

    Entry informationi

    Entry nameiQ8I4V8_PLAF7
    AccessioniPrimary (citable) accession number: Q8I4V8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3