Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidylprolyl isomerase

Gene

FKBP35

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • FK506 binding Source: GeneDB
  • peptidyl-prolyl cis-trans isomerase activity Source: GeneDB
  • protein dimerization activity Source: GeneDB

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: GeneDB

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation)
Gene namesi
Name:FKBP35Imported
ORF Names:PF3D7_1247400Imported, PFL2275cImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1247400.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GeneDB
  • nucleus Source: GeneDB

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106Combined sources
Disulfide bondi106InterchainCombined sources

Interactioni

GO - Molecular functioni

  • protein dimerization activity Source: GeneDB

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBNX-ray1.63A/B128-304[»]
2OFNNMR-A1-127[»]
2VN1X-ray2.35A/B1-127[»]
4J4NX-ray2.75A/B/C1-127[»]
4QT2X-ray1.44A7-127[»]
4QT3X-ray1.40A5-127[»]
ProteinModelPortaliQ8I4V8.
SMRiQ8I4V8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8I4V8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 126PPIase FKBP-typeInterPro annotationAdd BLAST90
Repeati144 – 177TPRPROSITE-ProRule annotationAdd BLAST34
Domaini194 – 261TPR_REGIONInterPro annotationAdd BLAST68
Repeati194 – 227TPRPROSITE-ProRule annotationAdd BLAST34
Repeati228 – 261TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

RepeatSAAS annotation, TPR repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000283560.
InParanoidiQ8I4V8.
KOiK01802.
OMAiSHEQENE.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I4V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEQEFEKV ELTADGGVIK TILKKGDEGE ENIPKKGNEV TVHYVGKLES
60 70 80 90 100
TGKVFDSSFD RNVPFKFHLE QGEVIKGWDI CVSSMRKNEK CLVRIESMYG
110 120 130 140 150
YGDEGCGESI PGNSVLLFEI ELLSFREAKK SIYDYTDEEK VQSAFDIKEE
160 170 180 190 200
GNEFFKKNEI NEAIVKYKEA LDFFIHTEEW DDQILLDKKK NIEISCNLNL
210 220 230 240 250
ATCYNKNKDY PKAIDHASKV LKIDKNNVKA LYKLGVANMY FGFLEEAKEN
260 270 280 290 300
LYKAASLNPN NLDIRNSYEL CVNKLKEARK KDKLTFGGMF DKGPLYEEKK

NSAN
Length:304
Mass (Da):34,827
Last modified:March 1, 2003 - v1
Checksum:i72DBA2427DDF50DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36539.1.
LN999947 Genomic DNA. Translation: CZT99629.1.
RefSeqiXP_001350859.1. XM_001350823.1.

Genome annotation databases

EnsemblProtistsiAAN36539; AAN36539; PFL2275c.
PFL2275c:mRNA; PFL2275c:pep; PFL2275c.
GeneDBiPF3D7_1247400.1:pep.
GeneIDi811507.
KEGGipfa:PFL2275c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36539.1.
LN999947 Genomic DNA. Translation: CZT99629.1.
RefSeqiXP_001350859.1. XM_001350823.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBNX-ray1.63A/B128-304[»]
2OFNNMR-A1-127[»]
2VN1X-ray2.35A/B1-127[»]
4J4NX-ray2.75A/B/C1-127[»]
4QT2X-ray1.44A7-127[»]
4QT3X-ray1.40A5-127[»]
ProteinModelPortaliQ8I4V8.
SMRiQ8I4V8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiAAN36539; AAN36539; PFL2275c.
PFL2275c:mRNA; PFL2275c:pep; PFL2275c.
GeneDBiPF3D7_1247400.1:pep.
GeneIDi811507.
KEGGipfa:PFL2275c.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1247400.

Phylogenomic databases

HOGENOMiHOG000283560.
InParanoidiQ8I4V8.
KOiK01802.
OMAiSHEQENE.

Miscellaneous databases

EvolutionaryTraceiQ8I4V8.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8I4V8_PLAF7
AccessioniPrimary (citable) accession number: Q8I4V8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 12, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.