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Q8I4V8 (Q8I4V8_PLAF7) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=5.2.1.8 EMBL AAN36539.1
Gene names
Name:FKBP35 EMBL AAN36539.1
ORF Names:PFL2275c EMBL AAN36539.1
OrganismPlasmodium falciparum (isolate 3D7) [Reference proteome]
Taxonomic identifier36329 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequences

Sequence LengthMass (Da)Tools
Q8I4V8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 72DBA2427DDF50DE

FASTA30434,827
        10         20         30         40         50         60 
MTTEQEFEKV ELTADGGVIK TILKKGDEGE ENIPKKGNEV TVHYVGKLES TGKVFDSSFD 

        70         80         90        100        110        120 
RNVPFKFHLE QGEVIKGWDI CVSSMRKNEK CLVRIESMYG YGDEGCGESI PGNSVLLFEI 

       130        140        150        160        170        180 
ELLSFREAKK SIYDYTDEEK VQSAFDIKEE GNEFFKKNEI NEAIVKYKEA LDFFIHTEEW 

       190        200        210        220        230        240 
DDQILLDKKK NIEISCNLNL ATCYNKNKDY PKAIDHASKV LKIDKNNVKA LYKLGVANMY 

       250        260        270        280        290        300 
FGFLEEAKEN LYKAASLNPN NLDIRNSYEL CVNKLKEARK KDKLTFGGMF DKGPLYEEKK 


NSAN 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the human malaria parasite Plasmodium falciparum."
Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. expand/collapse author list , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.
Nature 419:498-511(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate 3D7.
[2]"Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506."
Kotaka M., Ye H., Alag R., Hu G., Bozdech Z., Preiser P.R., Yoon H.S., Lescar J.
Biochemistry 47:5951-5961(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-127.
[3]"Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35)."
Kang C.B., Ye H., Yoon H.R., Yoon H.S.
Proteins 70:300-302(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-127.
[4]"Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide."
Alag R., Bharatham N., Dong A., Hills T., Harikishore A., Widjaja A.A., Shochat S.G., Hui R., Yoon H.S.
Protein Sci. 18:2115-2124(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 128-304.
[5]"Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent."
Harikishore A., Niang M., Rajan S., Preiser P.R., Yoon H.S.
Sci. Rep. 3:2501-2501(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1-127.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014188 Genomic DNA. Translation: AAN36539.1.
RefSeqXP_001350859.1. XM_001350823.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBNX-ray1.63A/B128-304[»]
2OFNNMR-A1-127[»]
2VN1X-ray2.35A/B1-127[»]
4J4NX-ray2.75A/B/C1-127[»]
ProteinModelPortalQ8I4V8.
SMRQ8I4V8. Positions 6-280.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5833.PFL2275c-1.

Proteomic databases

PRIDEQ8I4V8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsPFL2275c:mRNA; PFL2275c:pep; PFL2275c.
GeneID811507.
KEGGpfa:PFL2275c.

Organism-specific databases

EuPathDBPlasmoDB:PF3D7_1247400.

Phylogenomic databases

HOGENOMHOG000283560.
KOK01802.
OMAPNANVEY.
PhylomeDBQ8I4V8.
ProtClustDBCLSZ2431746.

Family and domain databases

Gene3D1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8I4V8.

Entry information

Entry nameQ8I4V8_PLAF7
AccessionPrimary (citable) accession number: Q8I4V8
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)