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Q8I4V8

- Q8I4V8_PLAF7

UniProt

Q8I4V8 - Q8I4V8_PLAF7

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Protein
Submitted name: FK506-binding protein (FKBP)-type peptidyl-propyl isomerase
Gene
FKBP35, PFL2275c
Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Names & Taxonomyi

Protein namesi
Submitted name:
FK506-binding protein (FKBP)-type peptidyl-propyl isomeraseImported (EC:5.2.1.8Imported)
Gene namesi
Name:FKBP35Imported
ORF Names:PFL2275cImported
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1247400.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8I4V8.

Interactioni

Protein-protein interaction databases

STRINGi5833.PFL2275c-1.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBNX-ray1.63A/B128-304[»]
2OFNNMR-A1-127[»]
2VN1X-ray2.35A/B1-127[»]
4J4NX-ray2.75A/B/C1-127[»]
ProteinModelPortaliQ8I4V8.
SMRiQ8I4V8. Positions 6-280.

Miscellaneous databases

EvolutionaryTraceiQ8I4V8.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000283560.
KOiK01802.
OMAiMESATYK.
PhylomeDBiQ8I4V8.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I4V8-1 [UniParc]FASTAAdd to Basket

« Hide

MTTEQEFEKV ELTADGGVIK TILKKGDEGE ENIPKKGNEV TVHYVGKLES    50
TGKVFDSSFD RNVPFKFHLE QGEVIKGWDI CVSSMRKNEK CLVRIESMYG 100
YGDEGCGESI PGNSVLLFEI ELLSFREAKK SIYDYTDEEK VQSAFDIKEE 150
GNEFFKKNEI NEAIVKYKEA LDFFIHTEEW DDQILLDKKK NIEISCNLNL 200
ATCYNKNKDY PKAIDHASKV LKIDKNNVKA LYKLGVANMY FGFLEEAKEN 250
LYKAASLNPN NLDIRNSYEL CVNKLKEARK KDKLTFGGMF DKGPLYEEKK 300
NSAN 304
Length:304
Mass (Da):34,827
Last modified:March 1, 2003 - v1
Checksum:i72DBA2427DDF50DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014188 Genomic DNA. Translation: AAN36539.1.
RefSeqiXP_001350859.1. XM_001350823.1.

Genome annotation databases

EnsemblProtistsiPFL2275c:mRNA; PFL2275c:pep; PFL2275c.
GeneIDi811507.
KEGGipfa:PFL2275c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014188 Genomic DNA. Translation: AAN36539.1 .
RefSeqi XP_001350859.1. XM_001350823.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FBN X-ray 1.63 A/B 128-304 [» ]
2OFN NMR - A 1-127 [» ]
2VN1 X-ray 2.35 A/B 1-127 [» ]
4J4N X-ray 2.75 A/B/C 1-127 [» ]
ProteinModelPortali Q8I4V8.
SMRi Q8I4V8. Positions 6-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5833.PFL2275c-1.

Proteomic databases

PRIDEi Q8I4V8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PFL2275c:mRNA ; PFL2275c:pep ; PFL2275c .
GeneIDi 811507.
KEGGi pfa:PFL2275c.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1247400.

Phylogenomic databases

HOGENOMi HOG000283560.
KOi K01802.
OMAi MESATYK.
PhylomeDBi Q8I4V8.

Miscellaneous databases

EvolutionaryTracei Q8I4V8.

Family and domain databases

Gene3Di 1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProi IPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. "Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506."
    Kotaka M., Ye H., Alag R., Hu G., Bozdech Z., Preiser P.R., Yoon H.S., Lescar J.
    Biochemistry 47:5951-5961(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-127.
  3. "Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35)."
    Kang C.B., Ye H., Yoon H.R., Yoon H.S.
    Proteins 70:300-302(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-127.
  4. "Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide."
    Alag R., Bharatham N., Dong A., Hills T., Harikishore A., Widjaja A.A., Shochat S.G., Hui R., Yoon H.S.
    Protein Sci. 18:2115-2124(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 128-304.
  5. "Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent."
    Harikishore A., Niang M., Rajan S., Preiser P.R., Yoon H.S.
    Sci. Rep. 3:2501-2501(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1-127.

Entry informationi

Entry nameiQ8I4V8_PLAF7
AccessioniPrimary (citable) accession number: Q8I4V8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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