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Protein
Submitted name:

FK506-binding protein (FKBP)-type peptidyl-propyl isomerase

Gene

FKBP35

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. FK506 binding Source: GeneDB_Pfalciparum
  2. peptidyl-prolyl cis-trans isomerase activity Source: GeneDB_Pfalciparum
  3. protein dimerization activity Source: GeneDB_Pfalciparum

GO - Biological processi

  1. chaperone-mediated protein folding Source: GO_Central
  2. negative regulation of protein phosphatase type 2B activity Source: GeneDB_Pfalciparum
  3. protein folding Source: GeneDB_Pfalciparum
  4. protein peptidyl-prolyl isomerization Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Names & Taxonomyi

Protein namesi
Submitted name:
FK506-binding protein (FKBP)-type peptidyl-propyl isomeraseImported (EC:5.2.1.8Imported)
Gene namesi
Name:FKBP35Imported
ORF Names:PFL2275cImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1247400.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GeneDB_Pfalciparum
  2. endoplasmic reticulum membrane Source: GO_Central
  3. nucleus Source: GeneDB_Pfalciparum
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8I4V8.

Interactioni

Protein-protein interaction databases

STRINGi5833.PFL2275c-1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBNX-ray1.63A/B128-304[»]
2OFNNMR-A1-127[»]
2VN1X-ray2.35A/B1-127[»]
4J4NX-ray2.75A/B/C1-127[»]
ProteinModelPortaliQ8I4V8.
SMRiQ8I4V8. Positions 6-280.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8I4V8.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000283560.
InParanoidiQ8I4V8.
KOiK01802.
OMAiMESATYK.
PhylomeDBiQ8I4V8.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I4V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEQEFEKV ELTADGGVIK TILKKGDEGE ENIPKKGNEV TVHYVGKLES
60 70 80 90 100
TGKVFDSSFD RNVPFKFHLE QGEVIKGWDI CVSSMRKNEK CLVRIESMYG
110 120 130 140 150
YGDEGCGESI PGNSVLLFEI ELLSFREAKK SIYDYTDEEK VQSAFDIKEE
160 170 180 190 200
GNEFFKKNEI NEAIVKYKEA LDFFIHTEEW DDQILLDKKK NIEISCNLNL
210 220 230 240 250
ATCYNKNKDY PKAIDHASKV LKIDKNNVKA LYKLGVANMY FGFLEEAKEN
260 270 280 290 300
LYKAASLNPN NLDIRNSYEL CVNKLKEARK KDKLTFGGMF DKGPLYEEKK

NSAN
Length:304
Mass (Da):34,827
Last modified:March 1, 2003 - v1
Checksum:i72DBA2427DDF50DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36539.1.
RefSeqiXP_001350859.1. XM_001350823.1.

Genome annotation databases

EnsemblProtistsiPFL2275c:mRNA; PFL2275c:pep; PFL2275c.
GeneIDi811507.
KEGGipfa:PFL2275c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36539.1.
RefSeqiXP_001350859.1. XM_001350823.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBNX-ray1.63A/B128-304[»]
2OFNNMR-A1-127[»]
2VN1X-ray2.35A/B1-127[»]
4J4NX-ray2.75A/B/C1-127[»]
ProteinModelPortaliQ8I4V8.
SMRiQ8I4V8. Positions 6-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PFL2275c-1.

Proteomic databases

PRIDEiQ8I4V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPFL2275c:mRNA; PFL2275c:pep; PFL2275c.
GeneIDi811507.
KEGGipfa:PFL2275c.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1247400.

Phylogenomic databases

HOGENOMiHOG000283560.
InParanoidiQ8I4V8.
KOiK01802.
OMAiMESATYK.
PhylomeDBiQ8I4V8.

Miscellaneous databases

EvolutionaryTraceiQ8I4V8.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506."
    Kotaka M., Ye H., Alag R., Hu G., Bozdech Z., Preiser P.R., Yoon H.S., Lescar J.
    Biochemistry 47:5951-5961(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-127.
  3. "Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35)."
    Kang C.B., Ye H., Yoon H.R., Yoon H.S.
    Proteins 70:300-302(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-127.
  4. "Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide."
    Alag R., Bharatham N., Dong A., Hills T., Harikishore A., Widjaja A.A., Shochat S.G., Hui R., Yoon H.S.
    Protein Sci. 18:2115-2124(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 128-304.
  5. "Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent."
    Harikishore A., Niang M., Rajan S., Preiser P.R., Yoon H.S.
    Sci. Rep. 3:2501-2501(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1-127, ACTIVE SITE.

Entry informationi

Entry nameiQ8I4V8_PLAF7
AccessioniPrimary (citable) accession number: Q8I4V8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.