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Protein
Submitted name:

Thymidylate kinase, putative

Gene

TMK

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451ADPCombined sources
Binding sitei182 – 1821ADP; via carbonyl oxygenCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 236ADPCombined sources

GO - Molecular functioni

  • ATP binding Source: InterPro
  • thymidylate kinase activity Source: GeneDB
  • uridylate kinase activity Source: GO_Central

GO - Biological processi

  • dTDP biosynthetic process Source: GO_Central
  • dTTP biosynthetic process Source: GeneDB
  • dUDP biosynthetic process Source: GeneDB
  • nucleotide phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

Nucleotide-bindingCombined sources

Enzyme and pathway databases

ReactomeiR-PFA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Submitted name:
Thymidylate kinase, putativeImported
Gene namesi
Name:TMKImported
ORF Names:PFL2465cImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1251300.

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176852.

PTM / Processingi

Proteomic databases

PRIDEiQ8I4S1.

PTM databases

SwissPalmiQ8I4S1.

Interactioni

Chemistry

BindingDBiQ8I4S1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WWFX-ray1.89A/B/C1-210[»]
2WWGX-ray2.40A/B/C1-210[»]
2WWHX-ray2.70A/B/C1-210[»]
2WWIX-ray2.99A/B/C1-210[»]
2YOFX-ray1.82A/B/C1-210[»]
2YOGX-ray1.50A/B1-210[»]
2YOHX-ray1.60A/B1-210[»]
ProteinModelPortaliQ8I4S1.
SMRiQ8I4S1. Positions 3-210.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8I4S1.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000229079.
InParanoidiQ8I4S1.
KOiK00943.
OMAiDLVMFLQ.
PhylomeDBiQ8I4S1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I4S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDKKKGKF IVFEGLDRSG KSTQSKLLVE YLKNNNVEVK HLYFPNRETG
60 70 80 90 100
IGQIISKYLK MENSMSNETI HLLFSANRWE HMNEIKSLLL KGIWVVCDRY
110 120 130 140 150
AYSGVAYSSG ALNLNKTWCM NPDQGLIKPD VVFYLNVPPN YAQNRSDYGE
160 170 180 190 200
EIYEKVETQK KIYETYKHFA HEDYWINIDA TRKIEDIHND IVKEVTKIKV
210
EPEEFNFLWS
Length:210
Mass (Da):24,691
Last modified:March 1, 2003 - v1
Checksum:iE9329D393B685FB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36577.1.
RefSeqiXP_001350897.1. XM_001350861.1.

Genome annotation databases

EnsemblProtistsiPFL2465c:mRNA; PFL2465c:pep; PFL2465c.
GeneDBiPF3D7_1251300.1:pep.
GeneIDi811545.
KEGGipfa:PFL2465c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA. Translation: AAN36577.1.
RefSeqiXP_001350897.1. XM_001350861.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WWFX-ray1.89A/B/C1-210[»]
2WWGX-ray2.40A/B/C1-210[»]
2WWHX-ray2.70A/B/C1-210[»]
2WWIX-ray2.99A/B/C1-210[»]
2YOFX-ray1.82A/B/C1-210[»]
2YOGX-ray1.50A/B1-210[»]
2YOHX-ray1.60A/B1-210[»]
ProteinModelPortaliQ8I4S1.
SMRiQ8I4S1. Positions 3-210.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ8I4S1.
ChEMBLiCHEMBL2176852.

PTM databases

SwissPalmiQ8I4S1.

Proteomic databases

PRIDEiQ8I4S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPFL2465c:mRNA; PFL2465c:pep; PFL2465c.
GeneDBiPF3D7_1251300.1:pep.
GeneIDi811545.
KEGGipfa:PFL2465c.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1251300.

Phylogenomic databases

HOGENOMiHOG000229079.
InParanoidiQ8I4S1.
KOiK00943.
OMAiDLVMFLQ.
PhylomeDBiQ8I4S1.

Enzyme and pathway databases

ReactomeiR-PFA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

EvolutionaryTraceiQ8I4S1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase."
    Whittingham J.L., Carrero-Lerida J., Brannigan J.A., Ruiz-Perez L.M., Silva A.P., Fogg M.J., Wilkinson A.J., Gilbert I.H., Wilson K.S., Gonzalez-Pacanowska D.
    Biochem. J. 428:499-509(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) IN COMPLEX WITH ADP.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).

Entry informationi

Entry nameiQ8I4S1_PLAF7
AccessioniPrimary (citable) accession number: Q8I4S1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 13, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.