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Q8I4E0

- Q8I4E0_CAEEL

UniProt

Q8I4E0 - Q8I4E0_CAEEL

Protein
Submitted name:

Protein UNC-25, isoform b

Gene

unc-25

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: WormBase
    2. pyridoxal phosphate binding Source: WormBase

    GO - Biological processi

    1. gamma-aminobutyric acid biosynthetic process Source: WormBase
    2. synaptic transmission, GABAergic Source: WormBase

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_183019. GABA synthesis, release, reuptake and degradation.
    REACT_183178. GABA synthesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein UNC-25, isoform bImported
    Gene namesi
    Name:unc-25Imported
    ORF Names:CELE_Y37D8A.23Imported, Y37D8A.23Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiY37D8A.23b; CE31832; WBGene00006762; unc-25.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: WormBase
    2. inhibitory synapse Source: WormBase
    3. neuronal cell body Source: WormBase
    4. synaptic vesicle Source: WormBase

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8I4E0.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.Y37D8A.23a.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8I4E0.
    SMRiQ8I4E0. Positions 13-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110441.
    HOGENOMiHOG000005382.
    KOiK01580.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8I4E0-1 [UniParc]FASTAAdd to Basket

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    MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN    50
    DRDQKILEFH HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP 100
    RFFNQISCGL DLVSMAGEWL TATANTNMFT YEIAPVFILM EKSVMARMWE 150
    AVGWDPEKAD GIFAPGGAIA NLYAMNAARH QLWPRSKHLG MKDIPTLCCF 200
    TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE AKIIECKKEG 250
    LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE 300
    HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL 350
    FQQDKPYDVS FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD 400
    LANYFTRRIK ETEGFELIIE NVSFARIPEH LFLVRAFKDS KLGAC 445
    Length:445
    Mass (Da):50,309
    Last modified:March 1, 2003 - v1
    Checksum:i4FC0C3AFC4E12801
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL032626 Genomic DNA. Translation: CAD45605.1.
    RefSeqiNP_001022831.1. NM_001027660.2.
    UniGeneiCel.7826.

    Genome annotation databases

    EnsemblMetazoaiY37D8A.23b; Y37D8A.23b; WBGene00006762.
    GeneIDi176713.
    KEGGicel:CELE_Y37D8A.23.
    UCSCiY37D8A.23a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL032626 Genomic DNA. Translation: CAD45605.1 .
    RefSeqi NP_001022831.1. NM_001027660.2.
    UniGenei Cel.7826.

    3D structure databases

    ProteinModelPortali Q8I4E0.
    SMRi Q8I4E0. Positions 13-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.Y37D8A.23a.

    Proteomic databases

    PRIDEi Q8I4E0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y37D8A.23b ; Y37D8A.23b ; WBGene00006762 .
    GeneIDi 176713.
    KEGGi cel:CELE_Y37D8A.23.
    UCSCi Y37D8A.23a. c. elegans.

    Organism-specific databases

    CTDi 176713.
    WormBasei Y37D8A.23b ; CE31832 ; WBGene00006762 ; unc-25.

    Phylogenomic databases

    GeneTreei ENSGT00730000110441.
    HOGENOMi HOG000005382.
    KOi K01580.

    Enzyme and pathway databases

    Reactomei REACT_183019. GABA synthesis, release, reuptake and degradation.
    REACT_183178. GABA synthesis.

    Miscellaneous databases

    NextBioi 893696.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.

    Entry informationi

    Entry nameiQ8I4E0_CAEEL
    AccessioniPrimary (citable) accession number: Q8I4E0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3