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Q8I4E0

- Q8I4E0_CAEEL

UniProt

Q8I4E0 - Q8I4E0_CAEEL

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Protein
Submitted name:

Protein UNC-25, isoform b

Gene
unc-25, CELE_Y37D8A.23, Y37D8A.23
Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: WormBase
  2. pyridoxal phosphate binding Source: WormBase

GO - Biological processi

  1. gamma-aminobutyric acid biosynthetic process Source: WormBase
  2. synaptic transmission, GABAergic Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_183019. GABA synthesis, release, reuptake and degradation.
REACT_183178. GABA synthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein UNC-25, isoform bImported
Gene namesi
Name:unc-25Imported
ORF Names:CELE_Y37D8A.23Imported, Y37D8A.23Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiY37D8A.23b; CE31832; WBGene00006762; unc-25.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: WormBase
  2. inhibitory synapse Source: WormBase
  3. neuronal cell body Source: WormBase
  4. synaptic vesicle Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8I4E0.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y37D8A.23a.

Structurei

3D structure databases

ProteinModelPortaliQ8I4E0.
SMRiQ8I4E0. Positions 13-440.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110441.
HOGENOMiHOG000005382.
KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I4E0-1 [UniParc]FASTAAdd to Basket

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MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN    50
DRDQKILEFH HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP 100
RFFNQISCGL DLVSMAGEWL TATANTNMFT YEIAPVFILM EKSVMARMWE 150
AVGWDPEKAD GIFAPGGAIA NLYAMNAARH QLWPRSKHLG MKDIPTLCCF 200
TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE AKIIECKKEG 250
LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE 300
HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL 350
FQQDKPYDVS FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD 400
LANYFTRRIK ETEGFELIIE NVSFARIPEH LFLVRAFKDS KLGAC 445
Length:445
Mass (Da):50,309
Last modified:March 1, 2003 - v1
Checksum:i4FC0C3AFC4E12801
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL032626 Genomic DNA. Translation: CAD45605.1.
RefSeqiNP_001022831.1. NM_001027660.2.
UniGeneiCel.7826.

Genome annotation databases

EnsemblMetazoaiY37D8A.23b; Y37D8A.23b; WBGene00006762.
GeneIDi176713.
KEGGicel:CELE_Y37D8A.23.
UCSCiY37D8A.23a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL032626 Genomic DNA. Translation: CAD45605.1 .
RefSeqi NP_001022831.1. NM_001027660.2.
UniGenei Cel.7826.

3D structure databases

ProteinModelPortali Q8I4E0.
SMRi Q8I4E0. Positions 13-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.Y37D8A.23a.

Proteomic databases

PRIDEi Q8I4E0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y37D8A.23b ; Y37D8A.23b ; WBGene00006762 .
GeneIDi 176713.
KEGGi cel:CELE_Y37D8A.23.
UCSCi Y37D8A.23a. c. elegans.

Organism-specific databases

CTDi 176713.
WormBasei Y37D8A.23b ; CE31832 ; WBGene00006762 ; unc-25.

Phylogenomic databases

GeneTreei ENSGT00730000110441.
HOGENOMi HOG000005382.
KOi K01580.

Enzyme and pathway databases

Reactomei REACT_183019. GABA synthesis, release, reuptake and degradation.
REACT_183178. GABA synthesis.

Miscellaneous databases

NextBioi 893696.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiQ8I4E0_CAEEL
AccessioniPrimary (citable) accession number: Q8I4E0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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