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Protein
Submitted name:

Uncharacterized protein

Gene

unc-25

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  • glutamate decarboxylase activity Source: WormBase
  • pyridoxal phosphate binding Source: WormBase

GO - Biological processi

  • gamma-aminobutyric acid biosynthetic process Source: WormBase
  • synaptic transmission, GABAergic Source: WormBase

Keywordsi

Molecular functionLyaseUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-888568. GABA synthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:unc-25Imported
ORF Names:CELE_Y37D8A.23Imported, Y37D8A.23Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY37D8A.23b; CE31832; WBGene00006762; unc-25.

Subcellular locationi

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ8I4E0.
PeptideAtlasiQ8I4E0.

Expressioni

Gene expression databases

BgeeiWBGene00006762.
ExpressionAtlasiQ8I4E0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8I4E0.
SMRiQ8I4E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
OrthoDBiEOG091G07ZU.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I4E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN
60 70 80 90 100
DRDQKILEFH HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP
110 120 130 140 150
RFFNQISCGL DLVSMAGEWL TATANTNMFT YEIAPVFILM EKSVMARMWE
160 170 180 190 200
AVGWDPEKAD GIFAPGGAIA NLYAMNAARH QLWPRSKHLG MKDIPTLCCF
210 220 230 240 250
TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE AKIIECKKEG
260 270 280 290 300
LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE
310 320 330 340 350
HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL
360 370 380 390 400
FQQDKPYDVS FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD
410 420 430 440
LANYFTRRIK ETEGFELIIE NVSFARIPEH LFLVRAFKDS KLGAC
Length:445
Mass (Da):50,309
Last modified:March 1, 2003 - v1
Checksum:i4FC0C3AFC4E12801
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAD45605.1.
RefSeqiNP_001022831.1. NM_001027660.2.
UniGeneiCel.7826.

Genome annotation databases

EnsemblMetazoaiY37D8A.23b; Y37D8A.23b; WBGene00006762.
GeneIDi176713.
UCSCiY37D8A.23a. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ8I4E0_CAEEL
AccessioniPrimary (citable) accession number: Q8I4E0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported