ID   Q8I4D9_CAEEL            Unreviewed;       433 AA.
AC   Q8I4D9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 133.
DE   SubName: Full=Glutamate decarboxylase {ECO:0000313|EMBL:CAD45606.2};
GN   Name=unc-25 {ECO:0000313|EMBL:CAD45606.2,
GN   ECO:0000313|WormBase:Y37D8A.23c};
GN   ORFNames=CELE_Y37D8A.23 {ECO:0000313|EMBL:CAD45606.2}, Y37D8A.23
GN   {ECO:0000313|WormBase:Y37D8A.23c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD45606.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAD45606.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD45606.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284603; CAD45606.2; -; Genomic_DNA.
DR   RefSeq; NP_001022832.1; NM_001027661.2.
DR   AlphaFoldDB; Q8I4D9; -.
DR   SMR; Q8I4D9; -.
DR   PeptideAtlas; Q8I4D9; -.
DR   EnsemblMetazoa; Y37D8A.23c.1; Y37D8A.23c.1; WBGene00006762.
DR   GeneID; 176713; -.
DR   UCSC; Y37D8A.23a; c. elegans.
DR   AGR; WB:WBGene00006762; -.
DR   WormBase; Y37D8A.23c; CE32012; WBGene00006762; unc-25.
DR   HOGENOM; CLU_011856_0_0_1; -.
DR   OrthoDB; 888358at2759; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006762; Expressed in larva and 3 other cell types or tissues.
DR   ExpressionAtlas; Q8I4D9; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:WormBase.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0060077; C:inhibitory synapse; IDA:WormBase.
DR   GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:WormBase.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; ISS:WormBase.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; ISS:WormBase.
DR   GO; GO:0009449; P:gamma-aminobutyric acid biosynthetic process; ISS:WormBase.
DR   GO; GO:0051932; P:synaptic transmission, GABAergic; IGI:WormBase.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.170; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR45677:SF10; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR45677; GLUTAMATE DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   1: Evidence at protein level;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Proteomics identification {ECO:0007829|EPD:Q8I4D9,
KW   ECO:0007829|PeptideAtlas:Q8I4D9};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT   MOD_RES         245
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   433 AA;  49233 MW;  F8267E0254CB8F60 CRC64;
     MLCSRILLRK SCEDVLRLGV RTGHPRFFNQ ISCGLDLVSM AGEWLTATAN TNMFTYEIAP
     VFILMEKSVM ARMWEAVGWD PEKADGIFAP GGAIANLYAM NAARHQLWPR SKHLGMKDIP
     TLCCFTSEDS HYSIKSASAV LGIGADYCFN IPTDKNGKMI PEALEAKIIE CKKEGLTPFF
     ACCTAGSTVY GAFDPLERVA NICERHKLWF HVDAAWGGGM LLSPEHRYKL AGIERANSVT
     WNPHKLMGAL LQCSACLFRQ DGLLFQCNQM SADYLFQQDK PYDVSFDTGD KAIQCGRHND
     VFKLWLMWKS KGMEGYRQQI NKLMDLANYF TRRIKETEGF ELIIENPEFL NICFWYVPSK
     IRNLEPAEMR ARLEKIAPKI KAGMMQRGTT MVGYQPDKQR PNFFRMIISN QAITREDLDF
     LIKEIVDIGE SLE
//