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Protein
Submitted name:

DNA mismatch repair protein MSH6, putative

Gene

PF3D7_0505500

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • damaged DNA binding Source: GeneDB
  • DNA-dependent ATPase activity Source: GO_Central
  • heteroduplex DNA loop binding Source: GO_Central

GO - Biological processi

  • DNA repair Source: GeneDB
  • maintenance of DNA repeat elements Source: GO_Central
  • mismatch repair Source: GO_Central

Enzyme and pathway databases

ReactomeiR-PFA-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Names & Taxonomyi

Protein namesi
Submitted name:
DNA mismatch repair protein MSH6, putativeImported
Gene namesi
ORF Names:PF3D7_0505500Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0505500.

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ8I447.
SMRiQ8I447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1199 – 1215DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili925 – 952Sequence analysisAdd BLAST28
Coiled coili997 – 1017Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000284078.
InParanoidiQ8I447.
KOiK08737.
OMAiTPMMAQY.
PhylomeDBiQ8I447.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
InterProiView protein in InterPro
IPR015536. DNA_mismatch_repair_MSH6_C.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR017261. DNA_mismatch_repair_MutS/MSH.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR036187. DNA_mismatch_repair_MutS_sf.
IPR036678. MutS_con_dom_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11361:SF31. PTHR11361:SF31. 1 hit.
PfamiView protein in Pfam
PF01624. MutS_I. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
PIRSFiPIRSF037677. DNA_mis_repair_Msh6. 1 hit.
SMARTiView protein in SMART
SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiView protein in PROSITE
PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSNKKQSS ILSFFKSNEE KTNKSSCLNE INNKVGDGKG HKQNEINNNV
60 70 80 90 100
PEKRKSGDDK SGVDSKNKNE KENLGSNKKI NMLDMFLSKG EMYNKPKIID
110 120 130 140 150
NINKEPINGD MLSTDKNMNV NKTNKMHNLF LDEEKTDMSK TKCSNDDVYD
160 170 180 190 200
NNVYNNNVYD NNVHNNNVHN NNVRNNNVHN NNIHNNNNYG NIYRNDNCVV
210 220 230 240 250
KSNECNNNGV ELDEDSNYQN MVHNQMLEGR NYMDNLESST EDDIIIKKKR
260 270 280 290 300
KIILDSVSDK ECSDAKENNI NKNNCSVDNK LTNLLYEPNK EIDDNLLLLD
310 320 330 340 350
DNNNNNIKKC IEKRKGDDSK KSQELDGLRN KYLNLPISIT NDKFRLYIEH
360 370 380 390 400
YFLYCNTFEF PKWIQPQYIR DINLRTPDHA DYDSSTIWTP PPDHKWAIEY
410 420 430 440 450
KQAHYTPGMQ QFWKIKSRNF DKIIFFKMGR FYEIFYIDAC LMHTICSLNW
460 470 480 490 500
MSGEHKPHLG FPEQSLHFYA KKVINSGHKV VVIEQMETPK ELEQRNKESI
510 520 530 540 550
GPKDKAIKRE INEIYTKGTI LHDNMLSAET KYLVCFYFDE IENMTNVNNN
560 570 580 590 600
IKDNDDDHNN IKDNDDDHNN IKDNNDDHNN IKDNNNYTFS QYDNKNKCNF
610 620 630 640 650
GFVVSDIATS YIAVGYCNDD ESRIVLRTIL AQLCPAEILY SSKNINKEVL
660 670 680 690 700
SIFKNIPTSP ELTCLNSFPN IISSFDEINK YFENMPSNLE IYKEQTSVIC
710 720 730 740 750
AFGGFIVYLR SLLLDKKIFR FCKIEKYDLF KRETYMVLDA TALKHLEILE
760 770 780 790 800
TQSGDTKNSL YDYVNKTCTN FGARNLRRWI CSPLLDCEKI RERLDVVDFL
810 820 830 840 850
KNNEQILSLI RMKLKKLPDI ERLLNKICIQ ASQSERGAVF FDNVVNTKLK
860 870 880 890 900
EFVTFLNAFK EIDTMLIDVN RIERDGELPS RLFQICNTPD ICKDNIKGSY
910 920 930 940 950
PNIGLITNEF LEKIYFDGDK EYKPAEGCDE DIDKINEKEK NVENKLNNVL
960 970 980 990 1000
EHMRTQLKIP TLKFVHAKFK YEVECPDNIP KSFLKNVEIT SAKKGYVRIH
1010 1020 1030 1040 1050
NDEIKSLVEK LEDIEQEKKD AIYPFFQKLF HLFYAHYEKY VSACRLVAEL
1060 1070 1080 1090 1100
DCLQSFAYVV LNTAFPLTRP ILHPMDSKQG EEKTPFLILE DNIHPVVAML
1110 1120 1130 1140 1150
MPNFISNNIY MGCDKEKQST LLLTGPNMGG KSTLLRQTAI SVILAQIGAF
1160 1170 1180 1190 1200
VPCTYCELTV VDKIFTRLGS SDNLFEGKST FLVELEDISN LLKQSTKYSL
1210 1220 1230 1240 1250
AILDELGRGT SSFDGTAIAL STLEQISDVI KCRCIFSTHY HLLVEEVKHN
1260 1270 1280 1290 1300
KNISNYHMSL SIDDEQEKII FLYKFIKGVC PKSFGIHIAK LAGLPKEIID
1310 1320 1330 1340 1350
LAHEKSLLFE NVTDEFCKII KYKNITRSLL NEEADEKLVT LFHKYKKEFA
Length:1,350
Mass (Da):156,440
Last modified:March 1, 2003 - v1
Checksum:iF7643AFD6B2BFFCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844504 Genomic DNA. Translation: CAD51420.1.
RefSeqiXP_001351613.1. XM_001351577.1.

Genome annotation databases

EnsemblProtistsiCAD51420; CAD51420; PF3D7_0505500.
GeneDBiPF3D7_0505500.1:pep.
GeneIDi812907.
KEGGipfa:PFE0270c.

Similar proteinsi

Entry informationi

Entry nameiQ8I447_PLAF7
AccessioniPrimary (citable) accession number: Q8I447
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported