ID   Q8I402_PLAF7            Unreviewed;       747 AA.
AC   Q8I402;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 171.
DE   SubName: Full=Peptidyl-prolyl cis-trans isomerase {ECO:0000313|EMBL:CAD51467.1};
DE            EC=5.2.1.8 {ECO:0000313|EMBL:CAD51467.1};
GN   ORFNames=PF3D7_0510200 {ECO:0000313|EMBL:CAD51467.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51467.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|EMBL:CAD51467.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA   Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA   Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA   Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0007829|PDB:2FU0}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 589-747.
RX   PubMed=17125854; DOI=10.1016/j.molbiopara.2006.10.011;
RA   Vedadi M., Lew J., Artz J., Amani M., Zhao Y., Dong A., Wasney G.A.,
RA   Gao M., Hills T., Brokx S., Qiu W., Sharma S., Diassiti A., Alam Z.,
RA   Melone M., Mulichak A., Wernimont A., Bray J., Loppnau P., Plotnikova O.,
RA   Newberry K., Sundararajan E., Houston S., Walker J., Tempel W.,
RA   Bochkarev A., Kozieradzki I., Edwards A., Arrowsmith C., Roos D., Kain K.,
RA   Hui R.;
RT   "Genome-scale protein expression and structural biology of Plasmodium
RT   falciparum and related Apicomplexan organisms.";
RL   Mol. Biochem. Parasitol. 151:100-110(2007).
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DR   EMBL; AL844504; CAD51467.1; -; Genomic_DNA.
DR   RefSeq; XP_001351660.1; XM_001351624.1.
DR   PDB; 2FU0; X-ray; 1.80 A; A=589-747.
DR   PDBsum; 2FU0; -.
DR   AlphaFoldDB; Q8I402; -.
DR   SMR; Q8I402; -.
DR   STRING; 36329.Q8I402; -.
DR   PaxDb; 5833-PFE0505w; -.
DR   EnsemblProtists; CAD51467; CAD51467; PF3D7_0510200.
DR   GeneID; 812836; -.
DR   KEGG; pfa:PF3D7_0510200; -.
DR   VEuPathDB; PlasmoDB:PF3D7_0510200; -.
DR   HOGENOM; CLU_012062_31_0_1; -.
DR   InParanoid; Q8I402; -.
DR   OMA; GMVEYWR; -.
DR   OrthoDB; 275452at2759; -.
DR   PhylomeDB; Q8I402; -.
DR   EvolutionaryTrace; Q8I402; -.
DR   Proteomes; UP000001450; Chromosome 5.
DR   GO; GO:0016018; F:cyclosporin A binding; ISS:GeneDB.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:GeneDB.
DR   GO; GO:0006457; P:protein folding; ISS:GeneDB.
DR   Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR   InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR   InterPro; IPR044666; Cyclophilin_A-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR45625; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED; 1.
DR   PANTHER; PTHR45625:SF4; PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00160; Pro_isomerase; 1.
DR   PRINTS; PR00153; CSAPPISMRASE.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50891; Cyclophilin-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00170; CSA_PPIASE_1; 1.
DR   PROSITE; PS50072; CSA_PPIASE_2; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2FU0};
KW   Isomerase {ECO:0000313|EMBL:CAD51467.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   REPEAT          150..181
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          599..745
FT                   /note="PPIase cyclophilin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50072"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  87040 MW;  AD8E42A379460B8A CRC64;
     MSKNDEYKNE KGEGEELPSS DGESSDGSFG PVPLQQNKDN INDENYNDEN YNDENYNDKN
     YNDNDYISGN EKDVVLLDSK KKKKNSVSCS SSSSINIPEN EELLNKKKRK VKGIIEENKK
     NQEKMKKKKI RINNDIYLKN LPTNKNYQVS YMHTDIVTHV VVSNKKKYII TASLNGIIKF
     WYKNIGCIEF VKHFKIHSDE IINIFISEDE EHLGSLSKDK TYKQFDITSF DMNIVIKLSF
     IPRTGEFIYS SIFSTEVKVA ISSSEKACIY IYKPLESDIC IQTIDFGCCN IIEIIKYNKF
     YDLCVFSDNE GLLDIVDVTN FKFPTSKEEK KSKTNNNMDH KLIDFMNKRY PIKKINFSFK
     SETDLYELCK YKTYALCISL SLDGEYMAIL SENYFLRIYK FESMKLYRVY DESTEMYLTA
     QNDPLKKELH IDSFDFGKRL FIEKEIKKYM KNQNINFNMI SFDESNQYII YSTFIGIKVV
     NFITNQLCYI IGKNEANLRY LSISIYQNII PINKVRTNIH ESLYINEKNI SDCALFCTVY
     KKARFYVFSK KKLNEHELDD RDIYNEQPTK NDVNSLISNP LKNIETIHKN TPKSAIIYTT
     MGDIHISLFY KECKKTVQNF SVHSINGYYN NCIFHRVIKH FMVQTGDPSG DGTGGESIWG
     NEFEDEFFDH LNHSKPFMVS MANCGPNTNG SQFFITTVPC PWLDFKHTVF GKVTQGSKIV
     LDIEKVRTDK RDKPLEDIKI LNIKINN
//