Q8I402 (Q8I402_PLAF7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cyclophilin, putative EMBL CAD51467.1
EC=5.2.1.8 EMBL CAD51467.1

Gene names

ORF Names:

PFE0505w EMBL CAD51467.1

Organism

Plasmodium falciparum (isolate 3D7) [Reference proteome]

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0). SAAS SAAS020892
Sequence similarities	Contains 1 PPIase cyclophilin-type domain. RuleBase RU003420 SAAS SAAS020892

Ontologies

Keywords
Domain	Repeat RuleBase RU003532 WD repeat RuleBase RU000362
Molecular function	Isomerase Rotamase RuleBase RU003420 SAAS SAAS020892
Technical term	3D-structure PDB 2FU0 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cyclosporin A binding Inferred from sequence or structural similarity Ref.2. Source: GeneDB_Pfalciparum peptidyl-prolyl cis-trans isomerase activity Inferred from sequence or structural similarity Ref.2. Source: GeneDB_Pfalciparum
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8I402 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: AD8E42A379460B8A	FASTA	747	87,040
	10 20 30 40 50 60 MSKNDEYKNE KGEGEELPSS DGESSDGSFG PVPLQQNKDN INDENYNDEN YNDENYNDKN 70 80 90 100 110 120 YNDNDYISGN EKDVVLLDSK KKKKNSVSCS SSSSINIPEN EELLNKKKRK VKGIIEENKK 130 140 150 160 170 180 NQEKMKKKKI RINNDIYLKN LPTNKNYQVS YMHTDIVTHV VVSNKKKYII TASLNGIIKF 190 200 210 220 230 240 WYKNIGCIEF VKHFKIHSDE IINIFISEDE EHLGSLSKDK TYKQFDITSF DMNIVIKLSF 250 260 270 280 290 300 IPRTGEFIYS SIFSTEVKVA ISSSEKACIY IYKPLESDIC IQTIDFGCCN IIEIIKYNKF 310 320 330 340 350 360 YDLCVFSDNE GLLDIVDVTN FKFPTSKEEK KSKTNNNMDH KLIDFMNKRY PIKKINFSFK 370 380 390 400 410 420 SETDLYELCK YKTYALCISL SLDGEYMAIL SENYFLRIYK FESMKLYRVY DESTEMYLTA 430 440 450 460 470 480 QNDPLKKELH IDSFDFGKRL FIEKEIKKYM KNQNINFNMI SFDESNQYII YSTFIGIKVV 490 500 510 520 530 540 NFITNQLCYI IGKNEANLRY LSISIYQNII PINKVRTNIH ESLYINEKNI SDCALFCTVY 550 560 570 580 590 600 KKARFYVFSK KKLNEHELDD RDIYNEQPTK NDVNSLISNP LKNIETIHKN TPKSAIIYTT 610 620 630 640 650 660 MGDIHISLFY KECKKTVQNF SVHSINGYYN NCIFHRVIKH FMVQTGDPSG DGTGGESIWG 670 680 690 700 710 720 NEFEDEFFDH LNHSKPFMVS MANCGPNTNG SQFFITTVPC PWLDFKHTVF GKVTQGSKIV 730 740 LDIEKVRTDK RDKPLEDIKI LNIKINN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[2]	"Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13." Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z. , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G. Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[3]	"Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms." Vedadi M., Lew J., Artz J., Amani M., Zhao Y., Dong A., Wasney G.A., Gao M., Hills T., Brokx S., Qiu W., Sharma S., Diassiti A., Alam Z., Melone M., Mulichak A., Wernimont A., Bray J. , Loppnau P., Plotnikova O., Newberry K., Sundararajan E., Houston S., Walker J., Tempel W., Bochkarev A., Kozieradzki I., Edwards A., Arrowsmith C., Roos D., Kain K., Hui R. Mol. Biochem. Parasitol. 151:100-110(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 589-747.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL844504 Genomic DNA. Translation: CAD51467.1.

RefSeq

XP_001351660.1. XM_001351624.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FU0	X-ray	1.80	A	589-747	[»]

ProteinModelPortal

Q8I402.

SMR

Q8I402. Positions 592-746.

ModBase

Search...

Protein-protein interaction databases

STRING

5833.PFE0505w-1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

PFE0505w:mRNA; PFE0505w:pep; PFE0505w.

GeneID

812836.

KEGG

pfa:PFE0505w.

Organism-specific databases

EuPathDB

PlasmoDB:PF3D7_0510200.

Phylogenomic databases

HOGENOM

HOG000213214.

KO

K12736.

OMA

DENYNDE.

ProtClustDB

CLSZ2429095.

Family and domain databases

Gene3D

2.130.10.10. 1 hit.

InterPro

IPR002130. Cyclophilin-like_PPIase_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]

Pfam

PF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]

PRINTS

PR00153. CSAPPISMRASE.

SMART

SM00320. WD40. 3 hits.
[Graphical view]

SUPFAM

SSF50891. CSA_PPIase. 1 hit.
SSF50978. WD40_like. 1 hit.

PROSITE

PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8I402.

Entry information

Entry name

Q8I402_PLAF7

Accession

Primary (citable) accession number: Q8I402

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)