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Q8I402

- Q8I402_PLAF7

UniProt

Q8I402 - Q8I402_PLAF7

Protein
Submitted name:

Cyclophilin, putative

Gene

PFE0505w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).SAAS annotation

    GO - Molecular functioni

    1. cyclosporin A binding Source: GeneDB_Pfalciparum
    2. peptidyl-prolyl cis-trans isomerase activity Source: GeneDB_Pfalciparum

    GO - Biological processi

    1. protein folding Source: GeneDB_Pfalciparum
    2. protein peptidyl-prolyl isomerization Source: GOC

    Keywords - Molecular functioni

    Isomerase, RotamaseUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cyclophilin, putativeImported (EC:5.2.1.8Imported)
    Gene namesi
    ORF Names:PFE0505wImported
    OrganismiPlasmodium falciparum (isolate 3D7)Imported
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 5

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_0510200.

    Interactioni

    Protein-protein interaction databases

    STRINGi5833.PFE0505w-1.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FU0X-ray1.80A589-747[»]
    ProteinModelPortaliQ8I402.
    SMRiQ8I402. Positions 592-746.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8I402.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PPIase cyclophilin-type domain.UniRule annotation
    Contains PPIase cyclophilin-type domain.SAAS annotation

    Keywords - Domaini

    RepeatUniRule annotation, WD repeatUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000213214.
    KOiK12736.
    OMAiDENYNDE.
    PhylomeDBiQ8I402.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view]
    PRINTSiPR00153. CSAPPISMRASE.
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50891. SSF50891. 1 hit.
    SSF50978. SSF50978. 2 hits.
    PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8I402-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKNDEYKNE KGEGEELPSS DGESSDGSFG PVPLQQNKDN INDENYNDEN    50
    YNDENYNDKN YNDNDYISGN EKDVVLLDSK KKKKNSVSCS SSSSINIPEN 100
    EELLNKKKRK VKGIIEENKK NQEKMKKKKI RINNDIYLKN LPTNKNYQVS 150
    YMHTDIVTHV VVSNKKKYII TASLNGIIKF WYKNIGCIEF VKHFKIHSDE 200
    IINIFISEDE EHLGSLSKDK TYKQFDITSF DMNIVIKLSF IPRTGEFIYS 250
    SIFSTEVKVA ISSSEKACIY IYKPLESDIC IQTIDFGCCN IIEIIKYNKF 300
    YDLCVFSDNE GLLDIVDVTN FKFPTSKEEK KSKTNNNMDH KLIDFMNKRY 350
    PIKKINFSFK SETDLYELCK YKTYALCISL SLDGEYMAIL SENYFLRIYK 400
    FESMKLYRVY DESTEMYLTA QNDPLKKELH IDSFDFGKRL FIEKEIKKYM 450
    KNQNINFNMI SFDESNQYII YSTFIGIKVV NFITNQLCYI IGKNEANLRY 500
    LSISIYQNII PINKVRTNIH ESLYINEKNI SDCALFCTVY KKARFYVFSK 550
    KKLNEHELDD RDIYNEQPTK NDVNSLISNP LKNIETIHKN TPKSAIIYTT 600
    MGDIHISLFY KECKKTVQNF SVHSINGYYN NCIFHRVIKH FMVQTGDPSG 650
    DGTGGESIWG NEFEDEFFDH LNHSKPFMVS MANCGPNTNG SQFFITTVPC 700
    PWLDFKHTVF GKVTQGSKIV LDIEKVRTDK RDKPLEDIKI LNIKINN 747
    Length:747
    Mass (Da):87,040
    Last modified:March 1, 2003 - v1
    Checksum:iAD8E42A379460B8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844504 Genomic DNA. Translation: CAD51467.1.
    RefSeqiXP_001351660.1. XM_001351624.1.

    Genome annotation databases

    EnsemblProtistsiPFE0505w:mRNA; PFE0505w:pep; PFE0505w.
    GeneIDi812836.
    KEGGipfa:PFE0505w.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844504 Genomic DNA. Translation: CAD51467.1 .
    RefSeqi XP_001351660.1. XM_001351624.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FU0 X-ray 1.80 A 589-747 [» ]
    ProteinModelPortali Q8I402.
    SMRi Q8I402. Positions 592-746.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5833.PFE0505w-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PFE0505w:mRNA ; PFE0505w:pep ; PFE0505w .
    GeneIDi 812836.
    KEGGi pfa:PFE0505w.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_0510200.

    Phylogenomic databases

    HOGENOMi HOG000213214.
    KOi K12736.
    OMAi DENYNDE.
    PhylomeDBi Q8I402.

    Miscellaneous databases

    EvolutionaryTracei Q8I402.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view ]
    PRINTSi PR00153. CSAPPISMRASE.
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50891. SSF50891. 1 hit.
    SSF50978. SSF50978. 2 hits.
    PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
      Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
      , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
      Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 589-747.

    Entry informationi

    Entry nameiQ8I402_PLAF7
    AccessioniPrimary (citable) accession number: Q8I402
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3