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Q8I3X4 (Q8I3X4_PLAF7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Purine nucleotide phosphorylase, putative EMBL CAD51497.1
EC=2.4.2.3 EMBL CAD51497.1
Gene names
ORF Names:PFE0660c EMBL CAD51497.1
OrganismPlasmodium falciparum (isolate 3D7)
Taxonomic identifier36329 [NCBI]
Taxonomic lineageEukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequences

Sequence LengthMass (Da)Tools
Q8I3X4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2159E9731C410A23

FASTA24526,858
        10         20         30         40         50         60 
MDNLLRHLKI SKEQITPVVL VVGDPGRVDK IKVVCDSYVD LAYNREYKSV ECHYKGQKFL 

        70         80         90        100        110        120 
CVSHGVGSAG CAVCFEELCQ NGAKVIIRAG SCGSLQPDLI KRGDICICNA AVREDRVSHL 

       130        140        150        160        170        180 
LIHGDFPAVG DFDVYDTLNK CAQELNVPVF NGISVSSDMY YPNKIIPSRL EDYSKANAAV 

       190        200        210        220        230        240 
VEMELATLMV IGTLRKVKTG GILIVDGCPF KWDEGDFDNN LVPHQLENMI KIALGACAKL 


ATKYA

« Hide

References

« Hide 'large scale' references
[1]"Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function."
Shi W., Ting L.M., Kicska G.A., Lewandowicz A., Tyler P.C., Evans G.B., Furneaux R.H., Kim K., Almo S.C., Schramm V.L.
J. Biol. Chem. 279:18103-18106(2004) [PubMed: 14982926] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 2-245.
[2]"Genome sequence of the human malaria parasite Plasmodium falciparum."
Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. expand/collapse author list , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.
Nature 419:498-511(2002) [PubMed: 12368864] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate 3D7.
[3]"Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z. expand/collapse author list , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
Nature 419:527-531(2002) [PubMed: 12368867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate 3D7.
[4]"Selective targeting of the 5'Methylthioinosine activity of Plasmodium Purine Nucleoside Phosphorylase."
Donaldson T., Ting L.M., Zhan C., Shi W., Zheng R., Decatur S., Fiser A., Almo S.C., Kim K.
Submitted (JAN-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 2-245.
[5]"Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases."
Chaikuad A., Brady R.L.
BMC Struct. Biol. 9:42-42(2009) [PubMed: 19575810] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS).
[6]"Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine."
Schnick C., Robien M.A., Brzozowski A.M., Dodson E.J., Murshudov G.N., Anderson L., Luft J.R., Mehlin C., Hol W.G., Brannigan J.A., Wilkinson A.J.
Acta Crystallogr. D Biol. Crystallogr. 61:1245-1254(2005) [PubMed: 16131758] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL844504 Genomic DNA. Translation: CAD51497.1.
RefSeqXP_001351690.1. XM_001351654.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NW4X-ray2.20A/B/C/D/E/F2-245[»]
1Q1GX-ray2.02A/B/C/D/E/F2-245[»]
1SQ6X-ray2.40A1-245[»]
2BSXX-ray2.00A1-245[»]
3ENZX-ray2.03A/B/C/D/E/F1-245[»]
3FOWX-ray2.80A/B2-245[»]
3PHCX-ray2.00A/B/C/D/E/F2-245[»]
ProteinModelPortalQ8I3X4.
SMRQ8I3X4. Positions 3-245.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8I3X4. 1 interaction.
MINTMINT-1672191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsPFE0660c:mRNA; PFE0660c:pep; PFE0660c.
GeneID812947.
KEGGpfa:PFE0660c.
NMPDRfig|36329.1.peg.3163.

Organism-specific databases

EuPathDBEupathDB:PFE0660c.

Phylogenomic databases

GeneTreeEPrGT00050000005946.
HOGENOMHBG617197.
OMAPEKAKNN.
ProtClustDBCLSZ2433331.

Family and domain databases

InterProIPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
KOK00757.
PANTHERPTHR21234. PNP_UDP. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8I3X4_PLAF7
AccessionPrimary (citable) accession number: Q8I3X4
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info