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Protein
Submitted name:

ATP-dependent DNA helicase UvrD

Gene

PF3D7_0514100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • 3'-5' DNA helicase activity Source: CACAO
  • ATP binding Source: InterPro
  • ATP-dependent 3'-5' DNA helicase activity Source: GeneDB
  • DNA binding Source: InterPro
  • single-stranded DNA-dependent ATPase activity Source: GeneDB

Keywordsi

Molecular functionHelicaseImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.12. 4889.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-dependent DNA helicase UvrDImported (EC:3.6.4.12Imported)
Gene namesi
ORF Names:PF3D7_0514100Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0514100.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GeneDB

Structurei

3D structure databases

ProteinModelPortaliQ8I3W6.
SMRiQ8I3W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 727UvrD-like helicase ATP-bindingInterPro annotationAdd BLAST693
Domaini729 – 1104UvrD-like helicase C-terminalInterPro annotationAdd BLAST376

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili561 – 591Sequence analysisAdd BLAST31
Coiled coili1064 – 1084Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000212539.
InParanoidiQ8I3W6.

Family and domain databases

InterProiView protein in InterPro
IPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR027417. P-loop_NTPase.
IPR014016. UvrD-like_ATP-bd.
IPR034739. UvrD/AddA_N.
PANTHERiPTHR11070. PTHR11070. 2 hits.
PfamiView protein in Pfam
PF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 2 hits.
SUPFAMiSSF52540. SSF52540. 8 hits.
PROSITEiView protein in PROSITE
PS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I3W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEDEVGKNI CSASVEMKKK KSKSTYILKN ILFNNFSEEQ QRIIEIPMNV
60 70 80 90 100
NLCIIACPGS GKTSTLTARI IKSIIEEKQS IVCITFTNYA ASDLKDKIMK
110 120 130 140 150
KINCLIDICV DNKINQKLFN NKNNKINFSL KNKCTLNNKM NKSIFKVLNT
160 170 180 190 200
VMFIGTIHSF CRYILYKYKG TFKILTDFIN TNIIKLAFNN FYSSMMSKTK
210 220 230 240 250
GTQPGFSTIL ERKSNKASTQ NCDPDKINTH NNDDNINNKN DYINNKNKND
260 270 280 290 300
YNNINNYDNI NNYDNINNDD NINNDDNINN DDNINNDDNI NNDDDINNCG
310 320 330 340 350
NCNQPKGIPS QLAYFINCMK NAEIKEDEEK EFYEEEHDIQ NDILNNDDNN
360 370 380 390 400
NDEDDDDDDE FYNYLYNFKH SYEQTNDYFA NEQVQSVLKK KNIIFLKKKI
410 420 430 440 450
KLMKYIELYN IKIEINDVEK MFYEEYKKIF KKAKNIYYDF DDLLIETYRL
460 470 480 490 500
MKDNADIRNK ILEEWNYVFC DEFQDTNTTQ FNILQFFVNH NVPSTLDQSI
510 520 530 540 550
YTSGNLENKD IKDNHNISMS TYKSKQYSHS VQNFFNEHKV DQQLCDQIYF
560 570 580 590 600
DKHCNNILMQ NKNQQATHKH SEEEEEQEEE KKKNKKTKKT NTFINQQKIK
610 620 630 640 650
TQTVLSYKQD EMSSSASSTY SYVKIEKEKK KYALNKIDDT YYNKKNIYSN
660 670 680 690 700
NDEILDIENE QTFFNNNCNE KNKTKKKCNL KDRSLTVIGD DDQSIYSFRG
710 720 730 740 750
AHINVFYKFL KDCNCLLFKL NNNFRSTREI VRVSQNLIIN NRTCRIQKQL
760 770 780 790 800
YTNNVQGNKI QFHAFKTPSD EISYILSEII YLKKNYNYKY GDFVILCRTN
810 820 830 840 850
KTLKETLKSI HNVDIKKKAY KYLINKFLND KQNHLIKQKE YNTKIIQNNN
860 870 880 890 900
TNHVYKNSPI GNDEINIYEN NQKYEEYMKE FHNIFDIDTF KIPIKELNKK
910 920 930 940 950
KAFFGSKEII ELITFLRFLL NVDDNIIFKK AFKIIKNMKN TKQIIDKLTS
960 970 980 990 1000
CQTNQHLSNI LMEYSHDIVH IKTQQNKIHK HERINNDKLS LFSCVQSITH
1010 1020 1030 1040 1050
LFILKKRQTI NKESSLRVLN IFTEKELKSI VDFFFCINYF LKFAAHINSV
1060 1070 1080 1090 1100
YYLVIEVLKK TNFLKRLQAK IQKKTDEEKK ENNIMNETIS HQRNDTMELH
1110 1120 1130 1140 1150
APQNKCSEQM EGNNYISRNA QDELKLINKK KTDEHEKLCS QEVIEKRVKR
1160 1170 1180 1190 1200
DNQNKENIYG HNKNEDNIYG HNKNEDNIYG HNKNEDNIYG DIKNKENIYG
1210 1220 1230 1240 1250
DKKNKDNIYD EVSYTNNLST TDKSYSTNIE DKKGNMKKRT FGEFIEKGKD
1260 1270 1280 1290 1300
TKKYISSDNN NNNNNNNSND SNNNNSNNSS NNSDMLDVNI VNEIRIKKDL
1310 1320 1330 1340 1350
ELLFNIGDKD LKYNEIQNIF IFLEMTTDYK PNLLQQSCLD CLFCFLNDFK
1360 1370 1380 1390 1400
NNVHEKMLVE KVTLTTIHKA KGLEWKVVFI INVTEGEIPQ AVDSKQDIIE
1410 1420 1430 1440
ERKIFYVGIT RAKFLLYLLC SIQNNNSEKN TVSRFINEMN I
Length:1,441
Mass (Da):170,292
Last modified:March 1, 2003 - v1
Checksum:iC22906041D8DDF1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844504 Genomic DNA. Translation: CAD51506.1.
RefSeqiXP_001351699.1. XM_001351663.1.

Genome annotation databases

EnsemblProtistsiCAD51506; CAD51506; PF3D7_0514100.
GeneDBiPF3D7_0514100.1:pep.
GeneIDi812956.
KEGGipfa:PFE0705c.

Similar proteinsi

Entry informationi

Entry nameiQ8I3W6_PLAF7
AccessioniPrimary (citable) accession number: Q8I3W6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported