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Protein
Submitted name:

Phosphatidylinositol 3-kinase

Gene

PF3D7_0515300

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: GeneDB
  • hemoglobin binding Source: GeneDB

GO - Biological processi

  • autophagosome assembly Source: GO_Central
  • autophagy of peroxisome Source: GO_Central
  • endocytosis Source: GeneDB
  • endosomal transport Source: GO_Central
  • intracellular transport Source: GeneDB
  • phosphatidylinositol-mediated signaling Source: GO_Central
  • protein phosphorylation Source: GO_Central

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotationImported, Transferase

Enzyme and pathway databases

ReactomeiR-PFA-1266695. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinaseImported (EC:2.7.1.137Imported)
Gene namesi
ORF Names:PF3D7_0515300Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0515300.

Subcellular locationi

GO - Cellular componenti

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PF3D7_1343700Q8IDQ23EBI-16154098,EBI-16154121

GO - Molecular functioni

  • hemoglobin binding Source: GeneDB

Protein-protein interaction databases

DIPiDIP-61519N.
IntActiQ8I3V5. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8I3V5.
SMRiQ8I3V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1087 – 1274PIK helicalInterPro annotationAdd BLAST188
Domaini1876 – 2132PI3K/PI4KInterPro annotationAdd BLAST257

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili796 – 816Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoidiQ8I3V5.
KOiK00914.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom_sf.
IPR000403. PI3/4_kinase_cat_dom.
IPR036940. PI3/4_kinase_cat_sf.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
PANTHERiPTHR10048. PTHR10048. 2 hits.
PfamiView protein in Pfam
PF00454. PI3_PI4_kinase. 1 hit.
PF00613. PI3Ka. 1 hit.
SMARTiView protein in SMART
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51545. PIK_HELICAL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I3V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRYDKCSS TKDLNYFFHL KLGFFVCYKN HNDKYSFKNK ILQKNDTILF
60 70 80 90 100
FKKKKKFMYL RKKKKKKKKK ILIQIIQEYN KYNEYFKYNS NLEGNQGFNK
110 120 130 140 150
KPEKNKNTKG NVYTDHTNQN AKSKIYNYDM NDDSYSNYVN NNNVFRISSF
160 170 180 190 200
LILNNEFFGY PLQFVCETEG RSRNHEHYPD VHGDNIKYNK CDDNKYNKCD
210 220 230 240 250
DNKYDKCDDN KYNKCDDNKY DTCDDNKYDT CDDNKYDTCD DNKYNKYDDD
260 270 280 290 300
KYDTCDDNKY NKYDDDKYNK YDDDKYNKYD DDKYEKSRKK KKLNNLYKTI
310 320 330 340 350
LTKKKRKKMN SNLCVINKIY KYPIKYCELN SKAFVFFIIK NVGVHKITYY
360 370 380 390 400
SYNKLFSKDG VLNQGIQICK LYHVNKNKKI KQIIFEALKN KITFSYDNNP
410 420 430 440 450
NNIKKKIYKF LKKNCAYHDL IKLFYFKGHK QREKCNKKLN MEKTFGVHKS
460 470 480 490 500
SRYNYKTYKK KKKIDMCKNY CDDILDTYNS KYYKGELSGQ HKHIKMTGEQ
510 520 530 540 550
KEEHHIKYTH LNFNHGKDET FYKELYKCNY IEKYISSVNY FLLERRRMFN
560 570 580 590 600
KYKQQELCVN KNEENNKNKN DDDNKNDDDN KNDDDNNKND DDNKNDDDDN
610 620 630 640 650
KNDDDNKNDD DDNKNDDDDN NKNNIQCDNH SDNIYMCGTY GNMENYNVPH
660 670 680 690 700
STNNTNLQSI KKRIINMNIL DNIRCNKTYK YIDKNKFKCF TYYSCKNYNV
710 720 730 740 750
CKKIIEKYKL YKFLKKKKIE GYMILNFLNF NKELIYYNEH KKDMSTLHDN
760 770 780 790 800
LFDVISNNQN ENVKYNHICN NNKYDWFFNS FDYVGNLEES ITCFNNHKKK
810 820 830 840 850
ENMKNIKNIK KKKKKNLFYN EQHNIKNNKN DYHFDKYPSS LYSHLTNKKM
860 870 880 890 900
VNNTEVNNIK DENSLQMYII NKDVTKNKDG NLLLNSYYNS KLGKSINTCS
910 920 930 940 950
KEIYKEEHKN VYIYNKKITK MNIKMKTEQK YICVDSKRNT RTYNSKNIRT
960 970 980 990 1000
YNSKNIRTYN SKNIRTYNRK NIRTYNRKNI RTYNRKNIRT YNRKNIRCNN
1010 1020 1030 1040 1050
RKKFHLNRNK KKNGCVKKYK LYDERNTLVY KNKIGSNHFF LKEEIGKSTK
1060 1070 1080 1090 1100
KLNDIFEHIS NYTNRISKNI NITNKNRYDD YPFDFLSKDK IEYISMLSPT
1110 1120 1130 1140 1150
INEIKTLNTI LTIPLIKMNE YEKNCIWRFR FQLLNRKETL GKFLKSINWN
1160 1170 1180 1190 1200
NKEEEEEAII LLNKWAKPGI ENCIELFYSH LHHYVIKKYI IDIIKNSKKE
1210 1220 1230 1240 1250
EIKLYLFQLV QSLRTFNYQH IDNLFINTLI QKCIKSKKLS IYFYWFLLSE
1260 1270 1280 1290 1300
AKDKIKGKLY LHIHKLFINK LMTSNIRKNK IILDILKNQN RFRNQLLYLT
1310 1320 1330 1340 1350
KIAKNKTDRI QNKTRKLRNF LFYYRTNYGY INIKDFIKNN IFISDHNVYD
1360 1370 1380 1390 1400
FLDICKMKRE NSLDTPMRGD NIGQPSYLGM VPGMGKSTDD SKNVYGDDNK
1410 1420 1430 1440 1450
NVYGDDNKNV YGDDSKNIYC DDNKNVYGDD NKNIYGDDSK NIYGDDNKNI
1460 1470 1480 1490 1500
FSDDNKNLYS DNNNNKHIRY NKYVKNISYE HFNEYPYDNK KSRNIYTCNK
1510 1520 1530 1540 1550
DICNSIYYLD NELTINYDIK DDLYFFQYKR SSDEKLLNTD LSNDSNDMIH
1560 1570 1580 1590 1600
YIDDSKNVKI ERNRDNSFFS NFLQFNDNLD FFLNATYSDE DNNYEILDDS
1610 1620 1630 1640 1650
INFVQKQKIK KIKTPLILPI DPNIELLSFL PEQSYVLRSS LYPIVIACLV
1660 1670 1680 1690 1700
RKKIKLYNEN YNNLIINNHT FYKNDQNKDN IINNLSYDKS YHSYYNSQFI
1710 1720 1730 1740 1750
KTLQNSFEST TSLNYHYNFL KCSNNNIFYK NKKIERIKPN TSIQKAFPSN
1760 1770 1780 1790 1800
ENILNRNQHV YYSNNQIVHN IKKMNKHKRD DYMINEKVLP CVSNSCLGDK
1810 1820 1830 1840 1850
LMPSHDKMRS SHDKMMPSHD KMMPSHDKLM SPHYTLMSSH DKPVAPSGVS
1860 1870 1880 1890 1900
SLGEKKSKDE KKNRKKYNEI YQLSIKKYIY KAGDDLRQDH LVIQIIYVMD
1910 1920 1930 1940 1950
NIWKRYGLDL KMTLYRVLAL STDDGFIEFV DYAESISSIK KNYKGEIRQY
1960 1970 1980 1990 2000
FIDNSTCSSS PLGFDTEILQ NFISSCAGYS VITYILGIGD RHLDNLMVTK
2010 2020 2030 2040 2050
DGRFFHIDFG YIFGEDPKPF SPPMKLCKEM IEAMGGAHSI GYEQFLKKCC
2060 2070 2080 2090 2100
LAYKYLRYHS QLIISLLDAM CDAGLKDMKM SPELCVLKVQ EKFRLDLNDE
2110 2120 2130
AAEIYFLSVI NASVKTLFPV VVDKLHEWAL NWK
Length:2,133
Mass (Da):255,921
Last modified:March 1, 2003 - v1
Checksum:iCE2E6C4B196FA4FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844504 Genomic DNA. Translation: CAD51517.1.
RefSeqiXP_001351710.1. XM_001351674.1.

Genome annotation databases

EnsemblProtistsiCAD51517; CAD51517; PF3D7_0515300.
GeneDBiPF3D7_0515300.1:pep.
GeneIDi812967.
KEGGipfa:PFE0765w.

Similar proteinsi

Entry informationi

Entry nameiQ8I3V5_PLAF7
AccessioniPrimary (citable) accession number: Q8I3V5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported