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Protein
Submitted name:

TFIIH basal transcription factor complex helicase XPD subunit

Gene

PF3D7_0934100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

  • 5'-3' DNA helicase activity Source: GeneDB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent DNA helicase activity Source: InterPro
  • DNA binding Source: InterPro
  • single-stranded DNA-dependent ATPase activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotationImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-6781823. Formation of TC-NER Pre-Incision Complex.
R-PFA-72086. mRNA Capping.
R-PFA-73776. RNA Polymerase II Promoter Escape.
R-PFA-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Submitted name:
TFIIH basal transcription factor complex helicase XPD subunitImported (EC:3.6.4.12Imported)
Gene namesi
ORF Names:PF3D7_0934100Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0934100.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

  • cytoplasm Source: GeneDB
  • nucleus Source: GeneDB

Keywords - Cellular componenti

NucleusSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ8I2H7.
SMRiQ8I2H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 416Helicase ATP-bindingInterPro annotationAdd BLAST409

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 116Sequence analysisAdd BLAST21
Coiled coili925 – 945Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000205390.
InParanoidiQ8I2H7.
KOiK10844.
OMAiPSVVRNY.
PhylomeDBiQ8I2H7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. HBB.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR006935. Helicase/UvrB_N.
IPR027417. P-loop_NTPase.
IPR001945. RAD3/XPD.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
PANTHERiPTHR11472:SF1. PTHR11472:SF1. 1 hit.
PfamiView protein in Pfam
PF06733. DEAD_2. 1 hit.
PF06777. HBB. 1 hit.
PF13307. Helicase_C_2. 1 hit.
PF04851. ResIII. 1 hit.
SMARTiView protein in SMART
SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiView protein in PROSITE
PS51193. HELICASE_ATP_BIND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I2H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVFNLDDVE IFFPYDYIYP EQYAYMKYLK KTLDSEGHCV LEMPTGTGKT
60 70 80 90 100
VAIFSLITSY QYHKKDEGKF IFCTRTVAEM EKSLIELKKV IQYRINVMKQ
110 120 130 140 150
RKVEKLKNEK DDVNDVIKND DVNDVIKNDD VNDVINNDDE EGANNSLDGS
160 170 180 190 200
KENVKEYNKH DDHINNLKEF GENSEILAIG ISARRCMCIN DKVLLKHERE
210 220 230 240 250
KIDEECRKLT ATFIREKKYI NNKIDNEIYH PNVDKISDFI LRNRHHLDIE
260 270 280 290 300
DYFDIYNSRN SLEEYDNIGL CGYYENYKKE FLYDLIKPGV YTIEDLKVLC
310 320 330 340 350
KNYKNKENVN VPICPYFCAK KIIEISKVII LNYQYVIDPK VSKALFSWKD
360 370 380 390 400
MNKNVHLKNK NDIIVFDEAH NIDSVCLEAL SVNIDRNILN KASMNITKLM
410 420 430 440 450
KKIEQSKMLN EQKLKEECNK ILEKIKLQKC NQSLNVTNNV INIDNMKCIN
460 470 480 490 500
HMDNINKTRS DGNVGSYLEK ETNKHHNIEG KPGELFVTNE QEKKKRKVES
510 520 530 540 550
SPVAYFDEDM NLMFSDFFLD ESFGDNEKKK KNHDNNNDIN NDDIKINDDI
560 570 580 590 600
KNNDDINNDD RNNNDDINNN NNDRNNNNGR NNNNDRNNNN EDEDHLNDLC
610 620 630 640 650
YSPLLMEDII KNVVIPGNIR KSEHFLNLMR IVVVYLKKYI NIYDITSEGP
660 670 680 690 700
LSFLYKFEKD TKLDTSFFKY CFDRLKSLLN NLQIVNIEDY SSLNIVCNFC
710 720 730 740 750
TLLGNYFKGF IIICEPYPEA TGIYDPLIQF ACLDSSIAMK TVINKYKSII
760 770 780 790 800
LTSGTITPLE LYPKLLNFKT VLTASFPMSF DRNCVCPLIV TKGSDLIPLS
810 820 830 840 850
SQFSLRNDLS VIKNYGILLV DMCKCIPDGI VAYFPSYIYM EQVISSWYEL
860 870 880 890 900
GVIANILEYK LIFIETKDIV STTIALHNFK KACDLGKGAV FLSICRGKIA
910 920 930 940 950
EGIDFDKHYG KCVILFGIPY QYTLSKILKS RLDFLKETYN IQENEFLTFD
960 970 980 990 1000
AMRQASQCVG RIIRNKKDYG IMIFSDIRYA KHDKKNKLPP WIIKCMDISN
1010 1020 1030 1040 1050
INLTVTTAVD ISKQFLLNMS QEYRETGQTK ISPLMLKNQV KCWTMVKSIL

NMDDFI
Length:1,056
Mass (Da):122,839
Last modified:March 1, 2003 - v1
Checksum:i3FCB46FC2432C26E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844508 Genomic DNA. Translation: CAD52016.1.
RefSeqiXP_001352206.1. XM_001352170.1.

Genome annotation databases

EnsemblProtistsiCAD52016; CAD52016; PF3D7_0934100.
GeneDBiPF3D7_0934100.1:pep.
GeneIDi813610.
KEGGipfa:PFI1650w.

Similar proteinsi

Entry informationi

Entry nameiQ8I2H7_PLAF7
AccessioniPrimary (citable) accession number: Q8I2H7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported