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Q8I1F6

- PRPD3_DROER

UniProt

Q8I1F6 - PRPD3_DROER

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Protein
Diphenoloxidase subunit A3
Gene
proPO59, Dox-A3, GG22822
Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone By similarity.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi209 – 2091Copper A By similarityBy similarity
Metal bindingi213 – 2131Copper A By similarityBy similarity
Metal bindingi239 – 2391Copper A By similarityBy similarity
Metal bindingi366 – 3661Copper B By similarityBy similarity
Metal bindingi370 – 3701Copper B By similarityBy similarity
Metal bindingi406 – 4061Copper B By similarityBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diphenoloxidase subunit A3 (EC:1.14.18.1)
Alternative name(s):
Tyrosinase A3
Gene namesi
Name:proPO59
Synonyms:Dox-A3
ORF Names:GG22822
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0064624. Dere\GG22822.

Subcellular locationi

Secreted By similarity By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 4848 By similarity
PRO_0000035903Add
BLAST
Chaini51 – 683633Diphenoloxidase subunit A3By similarity
PRO_0000035904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi358 – 3581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi574 ↔ 617 By similarity
Disulfide bondi576 ↔ 624 By similarity

Post-translational modificationi

Upon activation, a trypsin type protease cleaves prophenol oxidase to yield the active enzyme By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ8I1F6.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Phylogenomic databases

KOiK00505.
OrthoDBiEOG7XPZ54.
PhylomeDBiQ8I1F6.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
1.20.1370.10. 1 hit.
2.60.40.1520. 1 hit.
InterProiIPR013788. Hemocyanin/hexamerin.
IPR000896. Hemocyanin/hexamerin_mid_dom.
IPR005203. Hemocyanin_C.
IPR005204. Hemocyanin_N.
IPR014756. Ig_E-set.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11511. PTHR11511. 1 hit.
PfamiPF03723. Hemocyanin_C. 1 hit.
PF00372. Hemocyanin_M. 1 hit.
PF03722. Hemocyanin_N. 1 hit.
[Graphical view]
PRINTSiPR00187. HAEMOCYANIN.
SUPFAMiSSF48050. SSF48050. 1 hit.
SSF48056. SSF48056. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00209. HEMOCYANIN_1. 1 hit.
PS00210. HEMOCYANIN_2. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8I1F6-1 [UniParc]FASTAAdd to Basket

« Hide

MADKKNLLLL FDHPTEPVFM DKGGNGTVFD VPASYVTDRY NKMCKKVQRR    50
VSGGFEKNVL VKEIPIPDLS CSMRLGRSEQ FSLFLESHRQ MACHLIDVFI 100
KMPTVDELQS VAVYARDRVN PVLFNYALSV AMLHRSDTKD LGLPAFAQIF 150
PDRFIDSQML RTMREESFVV ERSAARLPVH SSVKYTASDL DVEHRLWYFR 200
EDLGVNLHHW HWHLVYPNTA PDRSIVDKDR RGELFYYMHQ QIIARYNAER 250
LCNHMARVQP FNNLEEPIAE GYFPKMDSLV ASRAFPPRFD NTRLSDVDRP 300
INQLRVGIDD MKRWRERIYE AIHQGYVLDA NHKKIVLDDV KGIDILGNII 350
ESSQLTPNKT LYGDLHNKGH ILIAFSHDPT NKHLEYAGVM GDASTAMRDP 400
IFYKWHAFID NLFQEHKRQL SPYTEEDLTF PDVRVQSIQV ESQGQVNRLT 450
TFWQESDVDM SRGLDFVPRG HVLARFTHLQ HHPFSYTIEV ENSSEATRYG 500
YVRIFLAPKL DDGNATMLLE QQRRMMVELD KFVVTMPPGS HTITRDSTES 550
SVTIPFKRTF RNMDNPGEPQ NFLCGCGWPQ HMLIPKGRAE GLSFELFVMV 600
SNYEDDKVDQ KPEDCECSIA ASYCGLRDRL YPDRKSMGFP FDRQPRSGSE 650
LLEKFLTPNM CSIEVIISHE ARTEKIPELP DHS 683
Length:683
Mass (Da):79,020
Last modified:September 22, 2009 - v2
Checksum:iE8955B2798B6C260
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3281L → M in AAO01013. 1 Publication
Sequence conflicti557 – 5571K → E in AAO01013. 1 Publication
Sequence conflicti568 – 5692EP → QL in AAO01013. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY190941 Genomic DNA. Translation: AAO01013.1.
CH954179 Genomic DNA. Translation: EDV56739.1.
RefSeqiXP_001976339.1. XM_001976303.1.

Genome annotation databases

EnsemblMetazoaiFBtr0142876; FBpp0141368; FBgn0064624.
GeneIDi6547312.
KEGGider:Dere_GG22822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY190941 Genomic DNA. Translation: AAO01013.1 .
CH954179 Genomic DNA. Translation: EDV56739.1 .
RefSeqi XP_001976339.1. XM_001976303.1.

3D structure databases

ProteinModelPortali Q8I1F6.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0142876 ; FBpp0141368 ; FBgn0064624 .
GeneIDi 6547312.
KEGGi der:Dere_GG22822.

Organism-specific databases

FlyBasei FBgn0064624. Dere\GG22822.

Phylogenomic databases

KOi K00505.
OrthoDBi EOG7XPZ54.
PhylomeDBi Q8I1F6.

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
1.20.1370.10. 1 hit.
2.60.40.1520. 1 hit.
InterProi IPR013788. Hemocyanin/hexamerin.
IPR000896. Hemocyanin/hexamerin_mid_dom.
IPR005203. Hemocyanin_C.
IPR005204. Hemocyanin_N.
IPR014756. Ig_E-set.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
PANTHERi PTHR11511. PTHR11511. 1 hit.
Pfami PF03723. Hemocyanin_C. 1 hit.
PF00372. Hemocyanin_M. 1 hit.
PF03722. Hemocyanin_N. 1 hit.
[Graphical view ]
PRINTSi PR00187. HAEMOCYANIN.
SUPFAMi SSF48050. SSF48050. 1 hit.
SSF48056. SSF48056. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00209. HEMOCYANIN_1. 1 hit.
PS00210. HEMOCYANIN_2. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiPRPD3_DROER
AccessioniPrimary (citable) accession number: Q8I1F6
Secondary accession number(s): B3NP06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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