ID   Q8I0U6_PLAF7            Unreviewed;      1085 AA.
AC   Q8I0U6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 127.
DE   SubName: Full=Ring-infected erythrocyte surface antigen {ECO:0000313|EMBL:CAD48982.1};
GN   ORFNames=PF3D7_0102200 {ECO:0000313|EMBL:CAD48982.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD48982.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|EMBL:CAD48982.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA   Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA   Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA   Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844501; CAD48982.1; -; Genomic_DNA.
DR   RefSeq; XP_001350954.1; XM_001350918.1.
DR   AlphaFoldDB; Q8I0U6; -.
DR   SMR; Q8I0U6; -.
DR   DIP; DIP-42983N; -.
DR   IntAct; Q8I0U6; 21.
DR   STRING; 36329.Q8I0U6; -.
DR   SwissPalm; Q8I0U6; -.
DR   PaxDb; 5833-PFA0110w; -.
DR   EnsemblProtists; CAD48982; CAD48982; PF3D7_0102200.
DR   GeneID; 813159; -.
DR   KEGG; pfa:PF3D7_0102200; -.
DR   VEuPathDB; PlasmoDB:PF3D7_0102200; -.
DR   HOGENOM; CLU_009994_0_0_1; -.
DR   InParanoid; Q8I0U6; -.
DR   OMA; MHGISTI; -.
DR   OrthoDB; 248973at2759; -.
DR   PhylomeDB; Q8I0U6; -.
DR   Proteomes; UP000001450; Chromosome 1.
DR   GO; GO:0020002; C:host cell plasma membrane; IDA:GeneDB.
DR   GO; GO:0020026; C:merozoite dense granule; IDA:GeneDB.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IDA:GeneDB.
DR   GO; GO:0050776; P:regulation of immune response; TAS:GeneDB.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; DnaJ domain; 1.
DR   Gene3D; 6.10.280.180; Plasmodium RESA, N-terminal helical domain; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR026894; DnaJ_X.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR019111; PRESA_N.
DR   InterPro; IPR044885; PRESA_N_sf.
DR   PANTHER; PTHR44094; DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR44094:SF8; J DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF14308; DnaJ-X; 1.
DR   Pfam; PF09687; PRESAN; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; Chaperone J-domain; 1.
DR   SUPFAM; SSF69349; Phage fibre proteins; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          523..587
FT                   /note="J"
FT                   /evidence="ECO:0000259|PROSITE:PS50076"
FT   REGION          428..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..1085
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..505
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        903..1085
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1085 AA;  126521 MW;  5BBBBD351642C74B CRC64;
     MRPFHAYSWI FSQQYMDTKN VKEKNPTIYS FDDEEKRNEN KSFLKVLCSK RGVLPIIGIL
     YIILNGNLGY NGSSSSGVQF TDRCSRNLYG ETLPVNPYAD SENPIVVSQV FGLPFEKPTF
     TLESPPDIDH TNILGFNEKF MTDVNRYRYS NNYEAIPHIS EFNPLIVDKV LFDYNEKVDN
     LGRSGGDIIK KMQTLWDEIM DINKRKYDSL KEKLQKTYSQ YKVQYDMPKE AYESKWTQCI
     KLIDQGGENL EERLNSQFKN WYRQKYLNLE EYRRLTVLNQ IAWKALSNQI QYSCRKIMNS
     DISSFKHINE LKSLEHRAAK AAEAEMKKRA QKPKKKKSRR GWLCCGGGDI ETVEPQQEEP
     VQTVQEQQVN EYGDILPSLR ASITNSAINY YDTVKDGVYL DHETSDALYT DEDLLFDLEK
     QKYMDMLDTS EEESVKENEE EHTVDDEHVE EHTADDEHVE EPTVADDEHV EEPTVADEHV
     EEPTVAEEHV EEPTVAEEHV EEPASDVQQT SEAAPTIEIP DTLYYDILGV GVNADMNEIT
     ERYFKLAENY YPYQRSGSTV FHNFRKVNEA YQVLGDIDKK RWYNKYGYDG IKQVNFMNPS
     IFYLLSSLEK FKDFTGTPQI VTLLRFFFEK RLSMNDLENK SEHLLKFMEQ YQKEREAHVS
     EYLLNILQPC IAGDSKWNVP IITKLEGLKG SRFDIPILES LRWIFKHVAK THLKKSSKSA
     KKLQQRTQAN KQELANINNN LMSTLKEYVG SSEQMNSITY NFENINSNVD NGNQSKNISD
     LSYTDQKEIL EKIVSYIVDI SLYDIENTAL NAAEQLLSDN SVDEKTLKKR AQSLKKLSSI
     MERYAGGKRN DKKAKKYDTQ DVVGYIMHGI STINKEMKNQ NENVPEHVQH NAEANVEHDA
     EENVEHDAEE NVEENVEENV EENVEENVEE NVEENVEENV EENVEENVEE NVEENVEENV
     EENVEENVEE YDEENVEEVE ENVEEYDEEN VEEVEENVEE NVEENVEENV EEYDEENVEE
     VEENVEENVE ENVEENVEEN VEEVEENVEE NVEENVEENV EENVEENVEE YDEENVEEHN
     EEYDE
//