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Protein

Probable 3',5'-cyclic phosphodiesterase pde-3

Gene

pde-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei356Proton donorPROSITE-ProRule annotation1
Metal bindingi360Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi421Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi422Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi422Divalent metal cation 2PROSITE-ProRule annotation1
Metal bindingi531Divalent metal cation 1PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • determination of adult lifespan Source: UniProtKB
  • negative regulation of cGMP-mediated signaling Source: UniProtKB
  • phototransduction Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • response to alkaline pH Source: UniProtKB
  • response to hydrogen peroxide Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-165160 PDE3B signalling
R-CEL-418457 cGMP effects
R-CEL-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-3 (EC:3.1.4.17)
Gene namesi
Name:pde-3
ORF Names:E01F3.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiE01F3.1a ; CE32847 ; WBGene00008443 ; pde-3
E01F3.1b ; CE43375 ; WBGene00008443 ; pde-3
E01F3.1c ; CE43353 ; WBGene00008443 ; pde-3
E01F3.1d ; CE43321 ; WBGene00008443 ; pde-3
E01F3.1e ; CE44810 ; WBGene00008443 ; pde-3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988461 – 678Probable 3',5'-cyclic phosphodiesterase pde-3Add BLAST678

Proteomic databases

EPDiQ8I0P7
PaxDbiQ8I0P7
PeptideAtlasiQ8I0P7
PRIDEiQ8I0P7

Expressioni

Gene expression databases

BgeeiWBGene00008443
ExpressionAtlasiQ8I0P7 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ8I0P7, 1 interactor
STRINGi6239.E01F3.1e

Structurei

3D structure databases

ProteinModelPortaliQ8I0P7
SMRiQ8I0P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 632PDEasePROSITE-ProRule annotationAdd BLAST352

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.By similarity

Phylogenomic databases

eggNOGiENOG410IEGG Eukaryota
ENOG410XT2V LUCA
GeneTreeiENSGT00760000119066
HOGENOMiHOG000007164
InParanoidiQ8I0P7
OMAiFPIFQIS

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform e (identifier: Q8I0P7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPGPPAVGG VSPPVMVPGS APPFQPTHQY FQHHYHQTPP GKLRDRSPRL
60 70 80 90 100
SAEMRKNRDT ATSSPASSGV SIQQRRGSTT QNSGVGSIGL PVLGGRGRGV
110 120 130 140 150
MSDGHMQRTF HEAMRQRRTS LPANSLSLNG AKVTGSSLSE AKGLIADMLM
160 170 180 190 200
NKELPGNVAS CLRAVTMLLE QRPLPLNGLL NDFGLPSVVE NPYGGESMVV
210 220 230 240 250
GASKPRISNI TFSTVTSATG LPTVPAEPNK ARSSSYWKTE ASPSNNNEHE
260 270 280 290 300
TPVDLLRKIS VSRKESGTHV DTVVTTIDGQ RYDTRELDTD PDLAETAVWS
310 320 330 340 350
FPIFQMSRKH PQTILSRLTY NIFQQAELFR IFKVSPIKFF NFFHALEKGY
360 370 380 390 400
WEIPYHNRIH AADVLHGCYY LSAHPVRSTF LTPKTPDSVL TPPHPHHQHS
410 420 430 440 450
SIMSQLSTLE LMALFTAAAM HDYDHPGRTN AFLVQVEDKK AILYNDRSVL
460 470 480 490 500
ENHHAAESWK LLNKPENHFI ENLDPAEMKR FRYLVLEYIL ATDLKQHFEI
510 520 530 540 550
IMTFTERLTE IDVQVETDRL LIGKLLIKMA DINSPTKPYG LHRQWTDRIC
560 570 580 590 600
EEFYEQGDDE RRRGLPITPY MDRGDAQVAK LQDSFIAHVV SPLATAMNEC
610 620 630 640 650
GLLPILPGLD TSELIINMEH NHRKWKEQIE LENGGSYEAQ ITCNGGTAVN
660 670
GVIEEESAST SDSPDPRRDS PLDSDLSQ
Note: No experimental confirmation available.
Length:678
Mass (Da):75,578
Last modified:February 19, 2014 - v4
Checksum:iD9548D666A154FF6
GO
Isoform a1 Publication (identifier: Q8I0P7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-234: PTVPAEPNKARSS → MNSKVFKSKKNFC
     678-678: Q → QVPFTICCSIAEEEYV

Note: No experimental confirmation available.Curated
Show »
Length:472
Mass (Da):54,195
Checksum:iB531D5A5A24184C5
GO
Isoform b (identifier: Q8I0P7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:625
Mass (Da):69,869
Checksum:iBC7FD6472A3F2967
GO
Isoform c (identifier: Q8I0P7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-201: HMQRTFHEAM...PYGGESMVVG → MFPFRRSESH...VIGQQNEGDK
     678-678: Q → QVPFTICCSIAEEEYV

Note: No experimental confirmation available.
Show »
Length:589
Mass (Da):66,388
Checksum:iF28C41B3D040F21E
GO
Isoform d (identifier: Q8I0P7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.
     187-234: SVVENPYGGE...PAEPNKARSS → MMSSPSTSRC...RVNSPLTAFA
     678-678: Q → QVPFTICCSIAEEEYV

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):57,604
Checksum:i063280420B4B2325
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0536581 – 221Missing in isoform a. CuratedAdd BLAST221
Alternative sequenceiVSP_0536591 – 186Missing in isoform d. CuratedAdd BLAST186
Alternative sequenceiVSP_0536601 – 104Missing in isoform c. CuratedAdd BLAST104
Alternative sequenceiVSP_0536611 – 53Missing in isoform b. CuratedAdd BLAST53
Alternative sequenceiVSP_053662105 – 201HMQRT…SMVVG → MFPFRRSESHSPASRCKSAG LPIATTNGFHSIPSSASSST QSINRQGSVDNLIFKLLTKK YMAKCLGFTPSRSSVAIQTT PVVEVAPVIGQQNEGDK in isoform c. CuratedAdd BLAST97
Alternative sequenceiVSP_053663187 – 234SVVEN…KARSS → MMSSPSTSRCGHGGVAPADA NGKEIQPFGVLVVNKLQKRV NSPLTAFA in isoform d. CuratedAdd BLAST48
Alternative sequenceiVSP_053664222 – 234PTVPA…KARSS → MNSKVFKSKKNFC in isoform a. CuratedAdd BLAST13
Alternative sequenceiVSP_053665678Q → QVPFTICCSIAEEEYV in isoform a, isoform c and isoform d. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93376, AL132949 Genomic DNA Translation: CAB07570.3
Z93376, Z82279, AL132949 Genomic DNA Translation: CAD59146.3
Z93376, AL132949 Genomic DNA Translation: CAT01013.1
Z93376, AL132949 Genomic DNA Translation: CAT01014.1
Z93376, AL132949, Z82279 Genomic DNA Translation: CBL43431.1
PIRiT20399
RefSeqiNP_001254452.1, NM_001267523.1 [Q8I0P7-4]
NP_001254453.1, NM_001267524.1 [Q8I0P7-1]
NP_001254454.1, NM_001267525.1 [Q8I0P7-5]
NP_497084.2, NM_064683.5 [Q8I0P7-2]
NP_871943.3, NM_182143.3 [Q8I0P7-3]
UniGeneiCel.9159

Genome annotation databases

EnsemblMetazoaiE01F3.1e; E01F3.1e; WBGene00008443 [Q8I0P7-1]
GeneIDi183981
UCSCiE01F3.1b c. elegans [Q8I0P7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDE3_CAEEL
AccessioniPrimary (citable) accession number: Q8I0P7
Secondary accession number(s): B7FAS9
, B7FAT0, G5EG24, Q9BH44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 19, 2014
Last modified: May 23, 2018
This is version 113 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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