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Q8I0P7 (PDE3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3',5'-cyclic phosphodiesterase pde-3

EC=3.1.4.17
Gene names
Name:pde-3
ORF Names:E01F3.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length678 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. UniProtKB P54750

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. UniProtKB P54750

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandcGMP
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform e (identifier: Q8I0P7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform a Ref.1 (identifier: Q8I0P7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-234: PTVPAEPNKARSS → MNSKVFKSKKNFC
     678-678: Q → QVPFTICCSIAEEEYV
Note: No experimental confirmation available.
Isoform b Ref.1 (identifier: Q8I0P7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
Note: No experimental confirmation available.
Isoform c (identifier: Q8I0P7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-201: HMQRTFHEAM...PYGGESMVVG → MFPFRRSESH...VIGQQNEGDK
     678-678: Q → QVPFTICCSIAEEEYV
Note: No experimental confirmation available.
Isoform d (identifier: Q8I0P7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.
     187-234: SVVENPYGGE...PAEPNKARSS → MMSSPSTSRC...RVNSPLTAFA
     678-678: Q → QVPFTICCSIAEEEYV
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 678678Probable 3',5'-cyclic phosphodiesterase pde-3
PRO_0000198846

Natural variations

Alternative sequence1 – 221221Missing in isoform a.
VSP_053658
Alternative sequence1 – 186186Missing in isoform d.
VSP_053659
Alternative sequence1 – 104104Missing in isoform c.
VSP_053660
Alternative sequence1 – 5353Missing in isoform b.
VSP_053661
Alternative sequence105 – 20197HMQRT…SMVVG → MFPFRRSESHSPASRCKSAG LPIATTNGFHSIPSSASSST QSINRQGSVDNLIFKLLTKK YMAKCLGFTPSRSSVAIQTT PVVEVAPVIGQQNEGDK in isoform c.
VSP_053662
Alternative sequence187 – 23448SVVEN…KARSS → MMSSPSTSRCGHGGVAPADA NGKEIQPFGVLVVNKLQKRV NSPLTAFA in isoform d.
VSP_053663
Alternative sequence222 – 23413PTVPA…KARSS → MNSKVFKSKKNFC in isoform a.
VSP_053664
Alternative sequence6781Q → QVPFTICCSIAEEEYV in isoform a, isoform c and isoform d.
VSP_053665

Sequences

Sequence LengthMass (Da)Tools
Isoform e [UniParc].

Last modified February 19, 2014. Version 4.
Checksum: D9548D666A154FF6

FASTA67875,578
        10         20         30         40         50         60 
MSPGPPAVGG VSPPVMVPGS APPFQPTHQY FQHHYHQTPP GKLRDRSPRL SAEMRKNRDT 

        70         80         90        100        110        120 
ATSSPASSGV SIQQRRGSTT QNSGVGSIGL PVLGGRGRGV MSDGHMQRTF HEAMRQRRTS 

       130        140        150        160        170        180 
LPANSLSLNG AKVTGSSLSE AKGLIADMLM NKELPGNVAS CLRAVTMLLE QRPLPLNGLL 

       190        200        210        220        230        240 
NDFGLPSVVE NPYGGESMVV GASKPRISNI TFSTVTSATG LPTVPAEPNK ARSSSYWKTE 

       250        260        270        280        290        300 
ASPSNNNEHE TPVDLLRKIS VSRKESGTHV DTVVTTIDGQ RYDTRELDTD PDLAETAVWS 

       310        320        330        340        350        360 
FPIFQMSRKH PQTILSRLTY NIFQQAELFR IFKVSPIKFF NFFHALEKGY WEIPYHNRIH 

       370        380        390        400        410        420 
AADVLHGCYY LSAHPVRSTF LTPKTPDSVL TPPHPHHQHS SIMSQLSTLE LMALFTAAAM 

       430        440        450        460        470        480 
HDYDHPGRTN AFLVQVEDKK AILYNDRSVL ENHHAAESWK LLNKPENHFI ENLDPAEMKR 

       490        500        510        520        530        540 
FRYLVLEYIL ATDLKQHFEI IMTFTERLTE IDVQVETDRL LIGKLLIKMA DINSPTKPYG 

       550        560        570        580        590        600 
LHRQWTDRIC EEFYEQGDDE RRRGLPITPY MDRGDAQVAK LQDSFIAHVV SPLATAMNEC 

       610        620        630        640        650        660 
GLLPILPGLD TSELIINMEH NHRKWKEQIE LENGGSYEAQ ITCNGGTAVN GVIEEESAST 

       670 
SDSPDPRRDS PLDSDLSQ 

« Hide

Isoform a [UniParc].

Checksum: B531D5A5A24184C5
Show »

FASTA47254,195
Isoform b [UniParc].

Checksum: BC7FD6472A3F2967
Show »

FASTA62569,869
Isoform c [UniParc].

Checksum: F28C41B3D040F21E
Show »

FASTA58966,388
Isoform d [UniParc].

Checksum: 063280420B4B2325
Show »

FASTA50757,604

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z93376, AL132949 Genomic DNA. Translation: CAB07570.3.
Z93376, Z82279, AL132949 Genomic DNA. Translation: CAD59146.3.
Z93376, AL132949 Genomic DNA. Translation: CAT01013.1.
Z93376, AL132949 Genomic DNA. Translation: CAT01014.1.
Z93376, AL132949, Z82279 Genomic DNA. Translation: CBL43431.1.
PIRT20399.
RefSeqNP_001254452.1. NM_001267523.1. [Q8I0P7-4]
NP_001254453.1. NM_001267524.1. [Q8I0P7-1]
NP_001254454.1. NM_001267525.1. [Q8I0P7-5]
NP_497084.2. NM_064683.5. [Q8I0P7-2]
NP_871943.3. NM_182143.3. [Q8I0P7-3]
UniGeneCel.9159.

3D structure databases

ProteinModelPortalQ8I0P7.
SMRQ8I0P7. Positions 290-626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8I0P7. 1 interaction.

Proteomic databases

PaxDbQ8I0P7.
PRIDEQ8I0P7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaE01F3.1b; E01F3.1b; WBGene00008443. [Q8I0P7-3]
E01F3.1e; E01F3.1e; WBGene00008443. [Q8I0P7-1]
GeneID183981.
KEGGcel:CELE_E01F3.1.
UCSCE01F3.1b. c. elegans. [Q8I0P7-1]

Organism-specific databases

CTD183981.
WormBaseE01F3.1a; CE32847; WBGene00008443; pde-3.
E01F3.1b; CE43375; WBGene00008443; pde-3.
E01F3.1c; CE43353; WBGene00008443; pde-3.
E01F3.1d; CE43321; WBGene00008443; pde-3.
E01F3.1e; CE44810; WBGene00008443; pde-3.

Phylogenomic databases

eggNOGNOG145074.
GeneTreeENSGT00750000117253.
HOGENOMHOG000007164.
OMATHRSIEY.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio923070.

Entry information

Entry namePDE3_CAEEL
AccessionPrimary (citable) accession number: Q8I0P7
Secondary accession number(s): B7FAS9 expand/collapse secondary AC list , B7FAT0, G5EG24, Q9BH44
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 19, 2014
Last modified: June 11, 2014
This is version 87 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase