SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8I0P7

- PDE3_CAEEL

UniProt

Q8I0P7 - PDE3_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable 3',5'-cyclic phosphodiesterase pde-3
Gene
pde-3, E01F3.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-3 (EC:3.1.4.17)
Gene namesi
Name:pde-3
ORF Names:E01F3.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiE01F3.1a; CE32847; WBGene00008443; pde-3.
E01F3.1b; CE43375; WBGene00008443; pde-3.
E01F3.1c; CE43353; WBGene00008443; pde-3.
E01F3.1d; CE43321; WBGene00008443; pde-3.
E01F3.1e; CE44810; WBGene00008443; pde-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 678678Probable 3',5'-cyclic phosphodiesterase pde-3
PRO_0000198846Add
BLAST

Proteomic databases

PaxDbiQ8I0P7.
PRIDEiQ8I0P7.

Interactioni

Protein-protein interaction databases

IntActiQ8I0P7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8I0P7.
SMRiQ8I0P7. Positions 290-626.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.By similarity

Phylogenomic databases

eggNOGiNOG145074.
GeneTreeiENSGT00750000117253.
HOGENOMiHOG000007164.
OMAiTHRSIEY.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform e (identifier: Q8I0P7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPGPPAVGG VSPPVMVPGS APPFQPTHQY FQHHYHQTPP GKLRDRSPRL    50
SAEMRKNRDT ATSSPASSGV SIQQRRGSTT QNSGVGSIGL PVLGGRGRGV 100
MSDGHMQRTF HEAMRQRRTS LPANSLSLNG AKVTGSSLSE AKGLIADMLM 150
NKELPGNVAS CLRAVTMLLE QRPLPLNGLL NDFGLPSVVE NPYGGESMVV 200
GASKPRISNI TFSTVTSATG LPTVPAEPNK ARSSSYWKTE ASPSNNNEHE 250
TPVDLLRKIS VSRKESGTHV DTVVTTIDGQ RYDTRELDTD PDLAETAVWS 300
FPIFQMSRKH PQTILSRLTY NIFQQAELFR IFKVSPIKFF NFFHALEKGY 350
WEIPYHNRIH AADVLHGCYY LSAHPVRSTF LTPKTPDSVL TPPHPHHQHS 400
SIMSQLSTLE LMALFTAAAM HDYDHPGRTN AFLVQVEDKK AILYNDRSVL 450
ENHHAAESWK LLNKPENHFI ENLDPAEMKR FRYLVLEYIL ATDLKQHFEI 500
IMTFTERLTE IDVQVETDRL LIGKLLIKMA DINSPTKPYG LHRQWTDRIC 550
EEFYEQGDDE RRRGLPITPY MDRGDAQVAK LQDSFIAHVV SPLATAMNEC 600
GLLPILPGLD TSELIINMEH NHRKWKEQIE LENGGSYEAQ ITCNGGTAVN 650
GVIEEESAST SDSPDPRRDS PLDSDLSQ 678

Note: No experimental confirmation available.

Length:678
Mass (Da):75,578
Last modified:February 19, 2014 - v4
Checksum:iD9548D666A154FF6
GO
Isoform a1 Publication (identifier: Q8I0P7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-234: PTVPAEPNKARSS → MNSKVFKSKKNFC
     678-678: Q → QVPFTICCSIAEEEYV

Note: No experimental confirmation available.

Show »
Length:472
Mass (Da):54,195
Checksum:iB531D5A5A24184C5
GO
Isoform b1 Publication (identifier: Q8I0P7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.

Show »
Length:625
Mass (Da):69,869
Checksum:iBC7FD6472A3F2967
GO
Isoform c (identifier: Q8I0P7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-201: HMQRTFHEAM...PYGGESMVVG → MFPFRRSESH...VIGQQNEGDK
     678-678: Q → QVPFTICCSIAEEEYV

Note: No experimental confirmation available.

Show »
Length:589
Mass (Da):66,388
Checksum:iF28C41B3D040F21E
GO
Isoform d (identifier: Q8I0P7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.
     187-234: SVVENPYGGE...PAEPNKARSS → MMSSPSTSRC...RVNSPLTAFA
     678-678: Q → QVPFTICCSIAEEEYV

Note: No experimental confirmation available.

Show »
Length:507
Mass (Da):57,604
Checksum:i063280420B4B2325
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 221221Missing in isoform a.
VSP_053658Add
BLAST
Alternative sequencei1 – 186186Missing in isoform d.
VSP_053659Add
BLAST
Alternative sequencei1 – 104104Missing in isoform c.
VSP_053660Add
BLAST
Alternative sequencei1 – 5353Missing in isoform b.
VSP_053661Add
BLAST
Alternative sequencei105 – 20197HMQRT…SMVVG → MFPFRRSESHSPASRCKSAG LPIATTNGFHSIPSSASSST QSINRQGSVDNLIFKLLTKK YMAKCLGFTPSRSSVAIQTT PVVEVAPVIGQQNEGDK in isoform c.
VSP_053662Add
BLAST
Alternative sequencei187 – 23448SVVEN…KARSS → MMSSPSTSRCGHGGVAPADA NGKEIQPFGVLVVNKLQKRV NSPLTAFA in isoform d.
VSP_053663Add
BLAST
Alternative sequencei222 – 23413PTVPA…KARSS → MNSKVFKSKKNFC in isoform a.
VSP_053664Add
BLAST
Alternative sequencei678 – 6781Q → QVPFTICCSIAEEEYV in isoform a, isoform c and isoform d.
VSP_053665

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z93376, AL132949 Genomic DNA. Translation: CAB07570.3.
Z93376, Z82279, AL132949 Genomic DNA. Translation: CAD59146.3.
Z93376, AL132949 Genomic DNA. Translation: CAT01013.1.
Z93376, AL132949 Genomic DNA. Translation: CAT01014.1.
Z93376, AL132949, Z82279 Genomic DNA. Translation: CBL43431.1.
PIRiT20399.
RefSeqiNP_001254452.1. NM_001267523.1. [Q8I0P7-4]
NP_001254453.1. NM_001267524.1. [Q8I0P7-1]
NP_001254454.1. NM_001267525.1. [Q8I0P7-5]
NP_497084.2. NM_064683.5. [Q8I0P7-2]
NP_871943.3. NM_182143.3. [Q8I0P7-3]
UniGeneiCel.9159.

Genome annotation databases

EnsemblMetazoaiE01F3.1b; E01F3.1b; WBGene00008443. [Q8I0P7-3]
E01F3.1e; E01F3.1e; WBGene00008443. [Q8I0P7-1]
GeneIDi183981.
KEGGicel:CELE_E01F3.1.
UCSCiE01F3.1b. c. elegans. [Q8I0P7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z93376 , AL132949 Genomic DNA. Translation: CAB07570.3 .
Z93376 , Z82279 , AL132949 Genomic DNA. Translation: CAD59146.3 .
Z93376 , AL132949 Genomic DNA. Translation: CAT01013.1 .
Z93376 , AL132949 Genomic DNA. Translation: CAT01014.1 .
Z93376 , AL132949 , Z82279 Genomic DNA. Translation: CBL43431.1 .
PIRi T20399.
RefSeqi NP_001254452.1. NM_001267523.1. [Q8I0P7-4 ]
NP_001254453.1. NM_001267524.1. [Q8I0P7-1 ]
NP_001254454.1. NM_001267525.1. [Q8I0P7-5 ]
NP_497084.2. NM_064683.5. [Q8I0P7-2 ]
NP_871943.3. NM_182143.3. [Q8I0P7-3 ]
UniGenei Cel.9159.

3D structure databases

ProteinModelPortali Q8I0P7.
SMRi Q8I0P7. Positions 290-626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8I0P7. 1 interaction.

Proteomic databases

PaxDbi Q8I0P7.
PRIDEi Q8I0P7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai E01F3.1b ; E01F3.1b ; WBGene00008443 . [Q8I0P7-3 ]
E01F3.1e ; E01F3.1e ; WBGene00008443 . [Q8I0P7-1 ]
GeneIDi 183981.
KEGGi cel:CELE_E01F3.1.
UCSCi E01F3.1b. c. elegans. [Q8I0P7-1 ]

Organism-specific databases

CTDi 183981.
WormBasei E01F3.1a ; CE32847 ; WBGene00008443 ; pde-3.
E01F3.1b ; CE43375 ; WBGene00008443 ; pde-3.
E01F3.1c ; CE43353 ; WBGene00008443 ; pde-3.
E01F3.1d ; CE43321 ; WBGene00008443 ; pde-3.
E01F3.1e ; CE44810 ; WBGene00008443 ; pde-3.

Phylogenomic databases

eggNOGi NOG145074.
GeneTreei ENSGT00750000117253.
HOGENOMi HOG000007164.
OMAi THRSIEY.

Miscellaneous databases

NextBioi 923070.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiPDE3_CAEEL
AccessioniPrimary (citable) accession number: Q8I0P7
Secondary accession number(s): B7FAS9
, B7FAT0, G5EG24, Q9BH44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 19, 2014
Last modified: June 11, 2014
This is version 87 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi