Q8I0G5 (COPG_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coatomer subunit gamma

Alternative name(s):
Gamma-coat protein
Short name=Gamma-COP

Gene names

Name:	gammaCop
Synonyms:	copg, gamma-Cop
ORF Names:	CG1528

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	883 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development. Ref.7 Ref.8 Ref.9
Subunit structure	Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits By similarity.
Subcellular location	Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle › COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum. Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity. Ref.8 Ref.9
Tissue specificity	Expressed in ovary, testis, testis tip, young spermatocytes, germ cells and follicle cells. Up-regulated expression within centrally to posteriorly located germarial cysts and in migrating follicle cells. Widespread expression in imaginal disks including eye-antennal disk, wing disk, third leg and haltere disk. Ref.6
Developmental stage	Expressed during spermatogenesis and at later stages of oogenesis. During embryonic and larval development, expressed ubiquitously. Starting at stage 10 embryos and lasting until the end of embryonic development, strongly expressed in the salivary glands and in cells of the presumptive proventriculus. Maternal expression abundant in early embryos. Zygotic expression commences in the epidermis and salivary glands from stage 11, initiates in the trachea at stage 13, and at early stage 15 is also detected in the foregut and hindgut tubes. Ref.6 Ref.8
Disruption phenotype	Narrow tracheal tubes and thin salivary glands with reduced tube diameter and impaired tube elongation. Fails to complete dorsal closure. Fails to efficiently secrete luminal components and assemble the luminal chitinous matrix during tracheal tube expansion. In salivary glands, fails in the luminal deposition and assembly of a distinct, transient intraluminal matrix. Disrupted endoplasmic reticulum and Golgi in embryos. Null mutants die late in embryogenesis with a poorly differentiated cuticle and denticle. Defects in cell rearrangements, in branch elongation, in tube dilation and tube fusion. Ref.8 Ref.9
Sequence similarities	Belongs to the COPG family. Contains 6 HEAT repeats.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Cytoplasm Cytoplasmic vesicle Endoplasmic reticulum Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	branch fusion, open tracheal system Inferred from mutant phenotype Ref.9. Source: FlyBase chitin-based embryonic cuticle biosynthetic process Inferred from mutant phenotype Ref.9. Source: FlyBase cytokinesis Inferred from mutant phenotype PubMed 15380073. Source: FlyBase extracellular matrix organization Inferred from mutant phenotype Ref.8. Source: FlyBase intracellular protein transport Inferred from electronic annotation. Source: InterPro larval salivary gland morphogenesis Inferred from mutant phenotype Ref.8. Source: FlyBase lumen formation, open tracheal system Inferred from mutant phenotype Ref.9. Source: FlyBase neuron projection morphogenesis Inferred from mutant phenotype PubMed 18604272. Source: FlyBase phagocytosis, engulfment Inferred from mutant phenotype PubMed 16336044. Source: FlyBase protein secretion Inferred from mutant phenotype Ref.8Ref.9. Source: FlyBase regulation of lipid storage Inferred from direct assay Ref.7. Source: FlyBase regulation of tube diameter, open tracheal system Inferred from mutant phenotype Ref.8. Source: FlyBase
Cellular_component	COPI vesicle coat Inferred from electronic annotation. Source: InterPro Golgi apparatus Inferred from direct assay Ref.9. Source: FlyBase cis-Golgi network Inferred from direct assay Ref.8. Source: FlyBase endoplasmic reticulum Inferred from direct assay Ref.8. Source: FlyBase
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: Q8I0G5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform A (identifier: Q8I0G5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-17: NYFSLTSHKKHRGHPS → GSFRREKDDEED

Note: No experimental confirmation available.

Isoform C (identifier: Q8I0G5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2-17: NYFSLTSHKKHRGHPS → GSFRREKDDEED
     18-18: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 883	883	Coatomer subunit gamma		PRO_0000405327
Regions
	Repeat	69 – 106	38	HEAT 1
	Repeat	292 – 329	38	HEAT 2
	Repeat	331 – 364	34	HEAT 3
	Repeat	365 – 401	37	HEAT 4
	Repeat	404 – 439	36	HEAT 5
	Repeat	476 – 513	38	HEAT 6
Natural variations
	Alternative sequence	2 – 17	16	NYFSL…RGHPS → GSFRREKDDEED in isoform A and isoform C.		VSP_040672
	Alternative sequence	18	1	Missing in isoform C.		VSP_040673
Experimental info
	Sequence conflict	280	1	A → V in AAF05719. Ref.1
	Sequence conflict	546	1	S → W in AAM29550. Ref.5
	Sequence conflict	724	1	A → T in AAM29550. Ref.5
	Sequence conflict	729	1	T → A in AAM29550. Ref.5
	Sequence conflict	771	1	I → V in AAM29550. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 7C610B0F7A39692F	FASTA	883	97,690
	10 20 30 40 50 60 MNYFSLTSHK KHRGHPSAGP SNAYQNLEKT SVLQETRTFN ETPVNPRKCI HILTKILYLI 70 80 90 100 110 120 NQGEQLVARE ATDCFFAMTK LFQSKDVVLR RMVYLGIKEL SSIAEDVIIV TSSLTKDMTG 130 140 150 160 170 180 KEDLYRAAAI RALCSITDNT MLQAVERYMK QCIVDKNAAV SCAALVSSLR LANTAGDVVK 190 200 210 220 230 240 RWANEAQEAL NSDNIMVQYH ALGLLYHIRK SDRLAVSKLV NKLTRGSLKS PYAVCMLIRI 250 260 270 280 290 300 ACKLIEEEDI PSEELSDSPL FTFIESCLRH KSEMVIYEAA HAIVNLKNTN PRMLSPAFSI 310 320 330 340 350 360 LQLFCSSPKA TLRFAAVRTL NKVAMTHPAA VTTCNLDLEG LITDSNRSVA TLAITTLLKT 370 380 390 400 410 420 GAESSVERLM KQISTFVAEI SDEFKVVVVQ AICALCTKYP RKHTVLMNFL SGMLREEGGL 430 440 450 460 470 480 EYKTSIVDTI ITIIEENADA KESGLSHLCE FIEDCEHVSL AVRILHLLGK EGPFAATPSK 490 500 510 520 530 540 YIRFIYNRVI LESPIVRAAA VTAMAQFGAS CPALLSNILV LLGRCQMDPD DEVRDRATYY 550 560 570 580 590 600 LSILNSERPE LYKNYIIERE NCSLALLEKS LVEHLNGDVD TRFDISIVPK AAIVKPVIAN 610 620 630 640 650 660 DVMLVTSSAP RPPKITREEE SAARLAQLPG IQVLGPIHRS TAPIQLTESE TEYTVQCIKH 670 680 690 700 710 720 IFGQHVVFQF DCLNTLSDQI LENVRVELTL PEGFTTRAVI PCPKLPYNDL QTTFVIVEFP 730 740 750 760 770 780 PDAANSIATF GATLRFVVKD CDPNTGEPES EEGYDDEYML EDLELTVADQ IQKTRKNNFQ 790 800 810 820 830 840 VSWDAADSEE WLQAEDTFVL SAVTTLQDAV NTIVKILGLG AANLSENVPE GTHLHTLLCS 850 860 870 880 GTFRGGAEIL VRAKLALSEG VTLNLTVRST DQDVAELITA AIG
	Isoform A [UniParc]. Checksum: 2D306F2ACAE8B055	FASTA	879	97,277
	10 20 30 40 50 60 MGSFRREKDD EEDAGPSNAY QNLEKTSVLQ ETRTFNETPV NPRKCIHILT KILYLINQGE 70 80 90 100 110 120 QLVAREATDC FFAMTKLFQS KDVVLRRMVY LGIKELSSIA EDVIIVTSSL TKDMTGKEDL 130 140 150 160 170 180 YRAAAIRALC SITDNTMLQA VERYMKQCIV DKNAAVSCAA LVSSLRLANT AGDVVKRWAN 190 200 210 220 230 240 EAQEALNSDN IMVQYHALGL LYHIRKSDRL AVSKLVNKLT RGSLKSPYAV CMLIRIACKL 250 260 270 280 290 300 IEEEDIPSEE LSDSPLFTFI ESCLRHKSEM VIYEAAHAIV NLKNTNPRML SPAFSILQLF 310 320 330 340 350 360 CSSPKATLRF AAVRTLNKVA MTHPAAVTTC NLDLEGLITD SNRSVATLAI TTLLKTGAES 370 380 390 400 410 420 SVERLMKQIS TFVAEISDEF KVVVVQAICA LCTKYPRKHT VLMNFLSGML REEGGLEYKT 430 440 450 460 470 480 SIVDTIITII EENADAKESG LSHLCEFIED CEHVSLAVRI LHLLGKEGPF AATPSKYIRF 490 500 510 520 530 540 IYNRVILESP IVRAAAVTAM AQFGASCPAL LSNILVLLGR CQMDPDDEVR DRATYYLSIL 550 560 570 580 590 600 NSERPELYKN YIIERENCSL ALLEKSLVEH LNGDVDTRFD ISIVPKAAIV KPVIANDVML 610 620 630 640 650 660 VTSSAPRPPK ITREEESAAR LAQLPGIQVL GPIHRSTAPI QLTESETEYT VQCIKHIFGQ 670 680 690 700 710 720 HVVFQFDCLN TLSDQILENV RVELTLPEGF TTRAVIPCPK LPYNDLQTTF VIVEFPPDAA 730 740 750 760 770 780 NSIATFGATL RFVVKDCDPN TGEPESEEGY DDEYMLEDLE LTVADQIQKT RKNNFQVSWD 790 800 810 820 830 840 AADSEEWLQA EDTFVLSAVT TLQDAVNTIV KILGLGAANL SENVPEGTHL HTLLCSGTFR 850 860 870 GGAEILVRAK LALSEGVTLN LTVRSTDQDV AELITAAIG
	Isoform C [UniParc]. Checksum: CD358D5D6AA1B423	FASTA	878	97,206
	10 20 30 40 50 60 MGSFRREKDD EEDGPSNAYQ NLEKTSVLQE TRTFNETPVN PRKCIHILTK ILYLINQGEQ 70 80 90 100 110 120 LVAREATDCF FAMTKLFQSK DVVLRRMVYL GIKELSSIAE DVIIVTSSLT KDMTGKEDLY 130 140 150 160 170 180 RAAAIRALCS ITDNTMLQAV ERYMKQCIVD KNAAVSCAAL VSSLRLANTA GDVVKRWANE 190 200 210 220 230 240 AQEALNSDNI MVQYHALGLL YHIRKSDRLA VSKLVNKLTR GSLKSPYAVC MLIRIACKLI 250 260 270 280 290 300 EEEDIPSEEL SDSPLFTFIE SCLRHKSEMV IYEAAHAIVN LKNTNPRMLS PAFSILQLFC 310 320 330 340 350 360 SSPKATLRFA AVRTLNKVAM THPAAVTTCN LDLEGLITDS NRSVATLAIT TLLKTGAESS 370 380 390 400 410 420 VERLMKQIST FVAEISDEFK VVVVQAICAL CTKYPRKHTV LMNFLSGMLR EEGGLEYKTS 430 440 450 460 470 480 IVDTIITIIE ENADAKESGL SHLCEFIEDC EHVSLAVRIL HLLGKEGPFA ATPSKYIRFI 490 500 510 520 530 540 YNRVILESPI VRAAAVTAMA QFGASCPALL SNILVLLGRC QMDPDDEVRD RATYYLSILN 550 560 570 580 590 600 SERPELYKNY IIERENCSLA LLEKSLVEHL NGDVDTRFDI SIVPKAAIVK PVIANDVMLV 610 620 630 640 650 660 TSSAPRPPKI TREEESAARL AQLPGIQVLG PIHRSTAPIQ LTESETEYTV QCIKHIFGQH 670 680 690 700 710 720 VVFQFDCLNT LSDQILENVR VELTLPEGFT TRAVIPCPKL PYNDLQTTFV IVEFPPDAAN 730 740 750 760 770 780 SIATFGATLR FVVKDCDPNT GEPESEEGYD DEYMLEDLEL TVADQIQKTR KNNFQVSWDA 790 800 810 820 830 840 ADSEEWLQAE DTFVLSAVTT LQDAVNTIVK ILGLGAANLS ENVPEGTHLH TLLCSGTFRG 850 860 870 GAEILVRAKL ALSEGVTLNL TVRSTDQDVA ELITAAIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution." Hahn Y., Lee Y.J., Yun J.H., Yang S.K., Park C.W., Mita K., Huh T.-L., Rhee M., Chung J.H. FEBS Lett. 482:31-36(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Strain: Berkeley. Tissue: Larva and Pupae.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[4]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C). Strain: Berkeley. Tissue: Embryo.
[6]	"Expression of COPI components during development of Drosophila melanogaster." Grieder N.C., Kloter U., Gehring W.J. Gene Expr. Patterns 6:11-21(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[7]	"COPI complex is a regulator of lipid homeostasis." Beller M., Sztalryd C., Southall N., Bell M., Jackle H., Auld D.S., Oliver B. PLoS Biol. 6:E292-E292(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"COPI vesicle transport is a common requirement for tube expansion in Drosophila." Jayaram S.A., Senti K.A., Tiklova K., Tsarouhas V., Hemphala J., Samakovlis C. PLoS ONE 3:E1964-E1964(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[9]	"gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster." Grieder N.C., Caussinus E., Parker D.S., Cadigan K., Affolter M., Luschnig S. PLoS ONE 3:E3241-E3241(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191563 mRNA. Translation: AAF05719.1. AE014297 Genomic DNA. Translation: AAN14275.1. AE014297 Genomic DNA. Translation: AAF57160.1. AE014297 Genomic DNA. Translation: ACZ95077.1. AY113545 mRNA. Translation: AAM29550.1. BT001628 mRNA. Translation: AAN71383.1.
RefSeq	NP_001163784.1. NM_001170313.1. NP_524608.1. NM_079869.3. NP_733432.1. NM_170553.2.
UniGene	Dm.1895.
3D structure databases
ProteinModelPortal	Q8I0G5.
SMR	Q8I0G5. Positions 25-320, 525-551, 616-883.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1018880.
STRING	7227.FBpp0085155.
Proteomic databases
PaxDb	Q8I0G5.
PRIDE	Q8I0G5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085794; FBpp0085155; FBgn0028968.
GeneID	43717.
KEGG	dme:Dmel_CG1528.
UCSC	CG1528-RA. d. melanogaster. CG1528-RB. d. melanogaster.
Organism-specific databases
CTD	43717.
FlyBase	FBgn0028968. gammaCop.
Phylogenomic databases
eggNOG	COG5240.
GeneTree	ENSGT00390000016313.
HOGENOM	HOG000250272.
InParanoid	Q8MYW4.
OMA	WDEVGEE.
PhylomeDB	Q8I0G5.
Gene expression databases
Bgee	Q8I0G5.
Family and domain databases
Gene3D	1.25.10.10. 1 hit. 2.60.40.1480. 1 hit. 3.30.310.30. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR002553. Clathrin/coatomer_adapt-like_N. IPR015873. Clathrin_a/coatomer_app_sub_C. IPR009028. Coatomer/calthrin_app_sub_C. IPR013041. Coatomer/clathrin_app_Ig-like. IPR017106. Coatomer_gsu. IPR014863. Coatomer_gsu_app. IPR013040. Coatomer_gsu_app_Ig-like-sub. [Graphical view]
PANTHER	PTHR10261. PTHR10261. 1 hit.
Pfam	PF01602. Adaptin_N. 1 hit. PF08752. Gamma-COP. 1 hit. [Graphical view]
PIRSF	PIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAM	SSF55711. AP2_adap_app. 1 hit. SSF48371. ARM-type_fold. 1 hit. SSF49348. Clath_adapt. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	43717.
NextBio	835406.

Entry information

Entry name

COPG_DROME

Accession

Primary (citable) accession number: Q8I0G5
Secondary accession number(s): E1JJ29 , Q8MYW4, Q9U677, Q9V9W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project