Unreviewed, UniProtKB/TrEMBL Q8I0E9 (Q8I0E9_DROME)

Names and origin

Protein names

Submitted name:
    Heat shock protein cognate 1, isoform C EMBL AAN11819.1
    EC=3.6.1.3
Submitted name:
    Heat shock protein cognate 1, isoform D EMBL AAN11820.1
    AT07372p EMBL AAN71033.1

Gene names

Name:	Hsc70-1 EMBL AAN11819.1 FlyBase FBgn0001216
ORF Names:	CG8937 FlyBase FBgn0001216, Dmel_CG8937 EMBL AAN11819.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the heat shock protein 70 family. RuleBase RU003322V2

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding RuleBase RU003322V2 Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity, uncoupled Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8I0E9-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 90B9B8B488A3330D	FASTA	555	61,347
	10 20 30 40 50 60 MKHWPFEVFA ENGKPRIRVE YKGERKSFYP EEVSSMVLTK MRETAEAYLG GTVTDAVVTV 70 80 90 100 110 120 PAYFNDSQRQ ATKDAGAIAG LNVLRIINEP TAAAIAYGLD KQGTSERNVL IFDLGGGTFD 130 140 150 160 170 180 VSVLTIEDGI FEVKATAGDT HLGGEDFDNR LVNHFVQEFQ RKHKKDLGQN KRALRRLRTA 190 200 210 220 230 240 CERAKRTLSS STQASIEIDS LFEGVDFYTS VTRARFEELN GDLFRGTMEP VAKALRDAKM 250 260 270 280 290 300 DKGQIHDIVL VGGSTRIPKV QRLLQDFFNG KELNKSINPD EAVAYGAAVQ AAILHGDKSE 310 320 330 340 350 360 AVQDLLLLDV TPLSLGIETA GGVMTTLIKR NTTIPTKQTQ IFTTYADNQP GVLIQVFEGE 370 380 390 400 410 420 RAMTRDNNSL GKFELSAIPP APRGVPQVEV TFDIDANGIL NVTALEKSTG KENRITITND 430 440 450 460 470 480 KGRLSKEDIE RMVNDAEAYR QADEQQRDRI NAKNQLESYC FQLRSTLDDE HLSSRFSPAD 490 500 510 520 530 540 RETIQQRSSE TIAWLDANQL AERQEFEHKQ QELERICSPI ITRLYQGAGM APPPTAGGSN 550 PGATGGSGPT IEEVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014296 Genomic DNA. Translation: AAN11819.1. AE014296 Genomic DNA. Translation: AAN11820.1. BT001277 mRNA. Translation: AAN71033.1.
RefSeq	NP_729940.1. NP_729941.1.
UniGene	Dm.1176
3D structure databases
HSSP	HSSP built from PDB template 3HSC based on UniProtKB P19120.
SMR	Q8I0E9. Positions 1-468.
ModBase	Search...
Proteomic databases
PRIDE	Q8I0E9.
Genome annotation databases
Ensembl	FBgn0001216. Drosophila melanogaster. [Contig view]
GeneID	39542.
Organism-specific databases
FlyBase	FBgn0001216. Hsc70-1.
Gene expression databases
ArrayExpress	Q8I0E9.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
ProDom	PD000089. Hsp70. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	814184.

Entry information

Entry name

Q8I0E9_DROME

Accession

Primary (citable) accession number: Q8I0E9

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)