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Q8I021

- CCL17_FELCA

UniProt

Q8I021 - CCL17_FELCA

Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 17
    Alternative name(s):
    CC chemokine TARC
    Small-inducible cytokine A17
    Thymus and activation-regulated chemokine
    Gene namesi
    Name:CCL17
    Synonyms:TARC
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 17PRO_0000227015Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed in thymus and also in spleen, lung, lymph node, kidney, small intestine, colon and skin.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000004337.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8I021.
    SMRiQ8I021. Positions 25-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45053.
    HOGENOMiHOG000036685.
    HOVERGENiHBG098492.
    KOiK05514.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8I021-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSLKLLLLV MLLLGASLQV THAARATNVG RECCLEYFKG AIPLRRLTGW   50
    YRTSGECSKD AIVFVTIHGK SICSDPKDTR VKKTVRYLQS IMNPVPQES 99
    Length:99
    Mass (Da):11,056
    Last modified:March 1, 2003 - v1
    Checksum:i2E3FAD5976B6F749
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB084139 mRNA. Translation: BAC22063.1.
    RefSeqiNP_001009849.1. NM_001009849.1.

    Genome annotation databases

    GeneIDi493832.
    KEGGifca:493832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB084139 mRNA. Translation: BAC22063.1 .
    RefSeqi NP_001009849.1. NM_001009849.1.

    3D structure databases

    ProteinModelPortali Q8I021.
    SMRi Q8I021. Positions 25-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000004337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493832.
    KEGGi fca:493832.

    Organism-specific databases

    CTDi 6361.

    Phylogenomic databases

    eggNOGi NOG45053.
    HOGENOMi HOG000036685.
    HOVERGENi HBG098492.
    KOi K05514.
    TreeFami TF334888.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the feline thymus and activation-regulated chemokine cDNA and its expression in lesional skin of cats with eosinophilic plaque."
      Maeda S., Okayama T., Ohmori K., Masuda K., Ohno K., Tsujimoto H.
      J. Vet. Med. Sci. 65:275-278(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCCL17_FELCA
    AccessioniPrimary (citable) accession number: Q8I021
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3