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Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:TARC
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 17PRO_0000227015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in thymus and also in spleen, lung, lymph node, kidney, small intestine, colon and skin.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000004337.

Structurei

3D structure databases

ProteinModelPortaliQ8I021.
SMRiQ8I021. Positions 25-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45053.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ8I021.
KOiK05514.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8I021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSLKLLLLV MLLLGASLQV THAARATNVG RECCLEYFKG AIPLRRLTGW
60 70 80 90
YRTSGECSKD AIVFVTIHGK SICSDPKDTR VKKTVRYLQS IMNPVPQES
Length:99
Mass (Da):11,056
Last modified:March 1, 2003 - v1
Checksum:i2E3FAD5976B6F749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084139 mRNA. Translation: BAC22063.1.
RefSeqiNP_001009849.1. NM_001009849.1.

Genome annotation databases

GeneIDi493832.
KEGGifca:493832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084139 mRNA. Translation: BAC22063.1.
RefSeqiNP_001009849.1. NM_001009849.1.

3D structure databases

ProteinModelPortaliQ8I021.
SMRiQ8I021. Positions 25-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000004337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493832.
KEGGifca:493832.

Organism-specific databases

CTDi6361.

Phylogenomic databases

eggNOGiNOG45053.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ8I021.
KOiK05514.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the feline thymus and activation-regulated chemokine cDNA and its expression in lesional skin of cats with eosinophilic plaque."
    Maeda S., Okayama T., Ohmori K., Masuda K., Ohno K., Tsujimoto H.
    J. Vet. Med. Sci. 65:275-278(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Thymus.

Entry informationi

Entry nameiCCL17_FELCA
AccessioniPrimary (citable) accession number: Q8I021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.