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Baculoviral IAP repeat-containing protein 5



Canis lupus familiaris (Dog) (Canis familiaris)
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli


Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.By similarity


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57ZincPROSITE-ProRule annotationBy similarity1
Metal bindingi60ZincPROSITE-ProRule annotationBy similarity1
Metal bindingi77ZincPROSITE-ProRule annotationBy similarity1
Metal bindingi84ZincPROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi


Molecular functionProtease inhibitor, Repressor, Thiol protease inhibitor
Biological processApoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-2467813. Separation of Sister Chromatids.
R-CFA-2500257. Resolution of Sister Chromatid Cohesion.
R-CFA-4615885. SUMOylation of DNA replication proteins.
R-CFA-5663220. RHO GTPases Activate Formins.

Protein family/group databases


Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 5
Alternative name(s):
Apoptosis inhibitor survivin
Gene namesi
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Chromosome By similarity
  • Chromosomecentromere By similarity
  • Cytoplasmcytoskeletonspindle By similarity
  • Chromosomecentromerekinetochore By similarity
  • Midbody By similarity

  • Note: Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223551 – 142Baculoviral IAP repeat-containing protein 5Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Phosphoserine; by AURKCBy similarity1
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei34Phosphothreonine; by CDK1 and CDK15By similarity1
Modified residuei48PhosphothreonineBy similarity1
Modified residuei90N6-acetyllysineBy similarity1
Modified residuei110N6-acetyllysineBy similarity1
Modified residuei112N6-acetyllysineBy similarity1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei117Phosphothreonine; by AURKBBy similarity1
Modified residuei129N6-acetyllysineBy similarity1

Post-translational modificationi

Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.By similarity
Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.By similarity
In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases



Subunit structurei

Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce.By similarity

GO - Molecular functioni

Protein-protein interaction databases



3D structure databases


Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 88BIRCuratedAdd BLAST71


The BIR repeat is necessary and sufficient for LAMTOR5 binding.By similarity

Sequence similaritiesi

Belongs to the IAP family.Curated

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.

Family and domain databases

CDDicd00022. BIR. 1 hit.
InterProiView protein in InterPro
IPR001370. BIR_rpt.
PfamiView protein in Pfam
PF00653. BIR. 1 hit.
SMARTiView protein in SMART
SM00238. BIR. 1 hit.
PROSITEiView protein in PROSITE
PS50143. BIR_REPEAT_2. 1 hit.


Sequence statusi: Complete.

Q8I009-1 [UniParc]FASTAAdd to basket

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110 120 130 140
Mass (Da):16,271
Last modified:March 7, 2006 - v2

Sequence databases

Select the link destinations:
Links Updated
AB180206 mRNA. Translation: BAD20570.1.
AY741504 mRNA. Translation: AAU89275.1.
RefSeqiNP_001003348.1. NM_001003348.1.

Genome annotation databases

EnsembliENSCAFT00000008542; ENSCAFP00000007914; ENSCAFG00000005302.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBIRC5_CANLF
AccessioniPrimary (citable) accession number: Q8I009
Secondary accession number(s): Q5XPZ7, Q6L673
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 7, 2006
Last modified: June 7, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program


Keywords - Technical termi

Complete proteome, Reference proteome


  1. SIMILARITY comments
    Index of protein domains and families