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Protein

Baculoviral IAP repeat-containing protein 5

Gene

BIRC5

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokenesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571ZincPROSITE-ProRule annotationBy similarity
Metal bindingi60 – 601ZincPROSITE-ProRule annotationBy similarity
Metal bindingi77 – 771ZincPROSITE-ProRule annotationBy similarity
Metal bindingi84 – 841ZincPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Repressor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-2467813. Separation of Sister Chromatids.
R-CFA-2500257. Resolution of Sister Chromatid Cohesion.
R-CFA-4615885. SUMOylation of DNA replication proteins.
R-CFA-5663220. RHO GTPases Activate Formins.
R-CFA-68877. Mitotic Prometaphase.

Protein family/group databases

MEROPSiI32.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 5
Alternative name(s):
Apoptosis inhibitor survivin
Gene namesi
Name:BIRC5
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Chromosome
  • Chromosomecentromere By similarity
  • Cytoplasmcytoskeletonspindle By similarity
  • Chromosomecentromerekinetochore By similarity
  • Midbody By similarity

  • Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Baculoviral IAP repeat-containing protein 5PRO_0000122355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei34 – 341Phosphothreonine; by CDK1 and CDK15By similarity
Modified residuei48 – 481PhosphothreonineBy similarity
Modified residuei90 – 901N6-acetyllysineBy similarity
Modified residuei110 – 1101N6-acetyllysineBy similarity
Modified residuei112 – 1121N6-acetyllysineBy similarity
Modified residuei115 – 1151N6-acetyllysineBy similarity
Modified residuei117 – 1171Phosphothreonine; by AURKBBy similarity
Modified residuei129 – 1291N6-acetyllysineBy similarity

Post-translational modificationi

Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting (By similarity).By similarity
Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation (By similarity).By similarity
In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8I009.

Interactioni

Subunit structurei

Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007914.

Structurei

3D structure databases

ProteinModelPortaliQ8I009.
SMRiQ8I009. Positions 5-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 8871BIRCuratedAdd
BLAST

Domaini

The BIR repeat is necessary and sufficient for LAMTOR5 binding.By similarity

Sequence similaritiesi

Belongs to the IAP family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00510000047537.
HOGENOMiHOG000008032.
HOVERGENiHBG050690.
InParanoidiQ8I009.
KOiK08731.
OMAiSCTPERM.
OrthoDBiEOG7SFJ01.
TreeFamiTF342652.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
InterProiIPR001370. BIR_rpt.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8I009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASSLPPAW QLYLKDHRVS TFKNWPFLEG CACTPDRMAE AGFIHCPTEN
60 70 80 90 100
EPDLAQCFFC FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLSE
110 120 130 140
FLKLDKERAK NKIAKETNNK QKEFEETAKK VRCAIEQLAA AE
Length:142
Mass (Da):16,271
Last modified:March 7, 2006 - v2
Checksum:i92846B4AF954DDD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180206 mRNA. Translation: BAD20570.1.
AY741504 mRNA. Translation: AAU89275.1.
RefSeqiNP_001003348.1. NM_001003348.1.
UniGeneiCfa.33943.

Genome annotation databases

EnsembliENSCAFT00000008542; ENSCAFP00000007914; ENSCAFG00000005302.
GeneIDi442936.
KEGGicfa:442936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180206 mRNA. Translation: BAD20570.1.
AY741504 mRNA. Translation: AAU89275.1.
RefSeqiNP_001003348.1. NM_001003348.1.
UniGeneiCfa.33943.

3D structure databases

ProteinModelPortaliQ8I009.
SMRiQ8I009. Positions 5-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007914.

Protein family/group databases

MEROPSiI32.005.

Proteomic databases

PaxDbiQ8I009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000008542; ENSCAFP00000007914; ENSCAFG00000005302.
GeneIDi442936.
KEGGicfa:442936.

Organism-specific databases

CTDi332.

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00510000047537.
HOGENOMiHOG000008032.
HOVERGENiHBG050690.
InParanoidiQ8I009.
KOiK08731.
OMAiSCTPERM.
OrthoDBiEOG7SFJ01.
TreeFamiTF342652.

Enzyme and pathway databases

ReactomeiR-CFA-2467813. Separation of Sister Chromatids.
R-CFA-2500257. Resolution of Sister Chromatid Cohesion.
R-CFA-4615885. SUMOylation of DNA replication proteins.
R-CFA-5663220. RHO GTPases Activate Formins.
R-CFA-68877. Mitotic Prometaphase.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
InterProiIPR001370. BIR_rpt.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of the survivin gene in dog neoplasm."
    Uchide T.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of canine survivin cDNA sequence."
    Scase T.J., Lamb E.R.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBIRC5_CANLF
AccessioniPrimary (citable) accession number: Q8I009
Secondary accession number(s): Q5XPZ7, Q6L673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 7, 2006
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.