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Protein
Submitted name:

Bcl-2 protein

Gene

bcl-2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processApoptosisPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Bcl-2 proteinImported
Gene namesi
Name:bcl-2Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei210 – 232HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ8I008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 30BH4_2InterPro annotationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 30BH4PROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOVERGENiHBG004472.
KOiK02161.

Family and domain databases

InterProiView protein in InterPro
IPR013278. Apop_reg_Bcl2.
IPR002475. Bcl2-like.
IPR004725. Bcl2/BclX.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF55. PTHR11256:SF55. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
PRINTSiPR01863. APOPREGBCL2.
PR01862. BCL2FAMILY.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
SUPFAMiSSF56854. SSF56854. 1 hit.
TIGRFAMsiTIGR00865. bcl-2. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
PS50063. BH4_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8I008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAGRTGYD NREIVMKYIH YELPQRGYEW DAGDAGAAPP GAAPAPGIFS
60 70 80 90 100
SQPGRTPAPA RTSPPPPPVA PAAAAAAAGP ALSPVPPVVH LTLRQAGDDF
110 120 130 140 150
SRRYRRDFAE MSSQLHLTPF TARGRFATVV EELFRDGVNW GRIVAFFEFG
160 170 180 190 200
GVMCVEGVNR EMSPLVDNIA LWMTEYLNRH LHTWIQDNGG WDAFVELYGP
210 220 230
SMQPLFDFSW LSLKALLSLA LVGACITLGA YLGHK
Length:235
Mass (Da):25,621
Last modified:March 1, 2003 - v1
Checksum:i2320B57C96B64548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096611 mRNA. Translation: BAC24136.1.
RefSeqiNP_001009340.1. NM_001009340.1.

Genome annotation databases

GeneIDi493934.
KEGGifca:493934.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ8I008_FELCA
AccessioniPrimary (citable) accession number: Q8I008
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 5, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)