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Protein

C-C chemokine receptor type 5

Gene

CCR5

Organism
Saimiri sciureus (Common squirrel monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 5
Short name:
C-C CKR-5
Short name:
CC-CKR-5
Short name:
CCR-5
Short name:
CCR5
Alternative name(s):
CD_antigen: CD195
Gene namesi
Name:CCR5
Synonyms:CMKBR5
OrganismiSaimiri sciureus (Common squirrel monkey)
Taxonomic identifieri9521 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5828Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 6810CytoplasmicSequence analysis
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 10213ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14117CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16625Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini167 – 19832ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 26025Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27717ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 30124Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini302 – 35251CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352C-C chemokine receptor type 5PRO_0000253618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31SulfotyrosineBy similarity
Glycosylationi6 – 61O-linked (GalNAc...)By similarity
Glycosylationi7 – 71O-linked (GalNAc...)Curated
Modified residuei10 – 101SulfotyrosineSequence analysis
Modified residuei14 – 141SulfotyrosineSequence analysis
Glycosylationi17 – 171O-linked (GalNAc...)Sequence analysis
Disulfide bondi101 ↔ 178PROSITE-ProRule annotation
Lipidationi321 – 3211S-palmitoyl cysteineBy similarity
Lipidationi323 – 3231S-palmitoyl cysteineBy similarity
Lipidationi324 – 3241S-palmitoyl cysteineBy similarity
Modified residuei337 – 3371Phosphoserine; by BARK1By similarity
Modified residuei342 – 3421Phosphoserine; by BARK1By similarity
Modified residuei349 – 3491Phosphoserine; by BARK1By similarity

Post-translational modificationi

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).By similarity
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen (By similarity).By similarity
Palmitoylation in the C-terminal is important for cell surface expression.By similarity
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

Interactioni

Subunit structurei

Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with CNIH4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8HZT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HZT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYQVSSPIY DIDYGPSEPC RKIDVKQMGA QLLPPLYSLV FLFGFVGNML
60 70 80 90 100
VVLILINCKR LKSMTDIYLL NLAISDLLFL FTIPFWAHYA AGQWDFGNTM
110 120 130 140 150
CQFLTALYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVTSV
160 170 180 190 200
ITWVVAVFAS LPGIIFTRSQ KEGYHYSCSP HFPFSQYRFW KNFETLKMVI
210 220 230 240 250
LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP
260 270 280 290 300
YNIVLLINTY PDFFGVNNCN SSNRLDQAMQ VTETLGMTHC CVNPIIYAFV
310 320 330 340 350
GEKFRNYLVI FFQKHIAKRF CKCCSIFQKE APERANSVYT RSTGEQEISV

GL
Length:352
Mass (Da):40,542
Last modified:March 1, 2003 - v1
Checksum:i9FC896FB7F074647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452615 mRNA. Translation: AAN14531.1.
AY278742 Genomic DNA. Translation: AAQ20010.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452615 mRNA. Translation: AAN14531.1.
AY278742 Genomic DNA. Translation: AAQ20010.1.

3D structure databases

ProteinModelPortaliQ8HZT9.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR5_SAISC
AccessioniPrimary (citable) accession number: Q8HZT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.