Q8HZR3 (FUT4_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-(1,3)-fucosyltransferase
EC=2.4.1.-

Alternative name(s):
Fucosyltransferase 4
Fucosyltransferase IV
Short name=Fuc-TIV
Short name=FucT-IV
Galactoside 3-L-fucosyltransferase

Gene names

Name:

FUT4

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens By similarity.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fucosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Alpha-(1,3)-fucosyltransferase		PRO_0000221099
Regions
	Topological domain	1 – 15	15	Cytoplasmic Potential
	Transmembrane	16 – 40	25	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	41 – 398	358	Lumenal Potential
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8HZR3 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: FAE2DA1E638706F4	FASTA	398	45,194
	10 20 30 40 50 60 MRARWGRRGA RRGGPGLPGT HLALLAASLL SSSVAIYVCW KQLPPLPWAS PSPPRPVNVL 70 80 90 100 110 120 LWWEPFRGRH NPRRPPPDCQ RRFNISGCVL HTDRAAYEEA QAVLFHHRDL VKGPPDWPPP 130 140 150 160 170 180 WGVQMPPVEE REGLVMDDEG QEAEAETSAA LGPRPAGQRW VWMNFESPSH SPGLQGLAGN 190 200 210 220 230 240 IFNWTLSYRA DSDIFVPYGY LYPRTHPSEQ PPGLVPPLAR KQGLVAWVVS NWDERQARVR 250 260 270 280 290 300 YYRQLSQYVT VDVFGKGGPG QPLPDAELVH TVARYKFYLA FENSQHLDYI TEKLWRNAFL 310 320 330 340 350 360 AGAVPVVLGP NRTNYERFVP SNAFIHVDDF PSASSLAAHL QFLDRNPTVY RGYFRWRRSH 370 380 390 AVHVTSFWDE PWCLACQAVQ KAGNQRKSVP NLAGWFQQ

References

[1]	Javaud C., Julien R. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF531092 mRNA. Translation: AAN63882.1.
IPI	IPI00697209.
RefSeq	NP_777161.1. NM_174736.2.
UniGene	Bt.12767.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8HZR3.
Protein family/group databases
CAZy	GT10. Glycosyltransferase Family 10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	282854.
KEGG	bta:282854.
Organism-specific databases
CTD	2526.
Phylogenomic databases
GeneTree	ENSGT00550000074250.
HOVERGEN	HBG000274.
InParanoid	Q8HZR3.
OrthoDB	EOG4H72BB.
Family and domain databases
InterPro	IPR001503. Glyco_trans_10. [Graphical view]
KO	K07632.
PANTHER	PTHR11929. Glyco_trans_10. 1 hit.
Pfam	PF00852. Glyco_transf_10. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT4_BOVIN

Accession

Primary (citable) accession number: Q8HZR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program