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Reviewed, UniProtKB/Swiss-Prot Q8HZR3 (FUT4_BOVIN)

Last modified June 16, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha-(1,3)-fucosyltransferase
    EC=2.4.1.-
Alternative name(s):
    Galactoside 3-L-fucosyltransferase
    Fucosyltransferase 4
    Fucosyltransferase IV
      Short name=FucT-IV
      Short name=Fuc-TIV
Gene names
Name: FUT4
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.

Sequence similarities

Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
   Cellular componentGolgi apparatus
Membrane
   DomainSignal-anchor
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processprotein amino acid glycosylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentGolgi cisterna membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionfucosyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Alpha-(1,3)-fucosyltransferase
PRO_0000221099

Regions

Topological domain1 – 1515Cytoplasmic Potential
Transmembrane16 – 4025Signal-anchor for type II membrane protein Potential
Topological domain41 – 398358Lumenal Potential

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8HZR3-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: FAE2DA1E638706F4

FASTA39845,194
        10         20         30         40         50         60 
MRARWGRRGA RRGGPGLPGT HLALLAASLL SSSVAIYVCW KQLPPLPWAS PSPPRPVNVL 

        70         80         90        100        110        120 
LWWEPFRGRH NPRRPPPDCQ RRFNISGCVL HTDRAAYEEA QAVLFHHRDL VKGPPDWPPP 

       130        140        150        160        170        180 
WGVQMPPVEE REGLVMDDEG QEAEAETSAA LGPRPAGQRW VWMNFESPSH SPGLQGLAGN 

       190        200        210        220        230        240 
IFNWTLSYRA DSDIFVPYGY LYPRTHPSEQ PPGLVPPLAR KQGLVAWVVS NWDERQARVR 

       250        260        270        280        290        300 
YYRQLSQYVT VDVFGKGGPG QPLPDAELVH TVARYKFYLA FENSQHLDYI TEKLWRNAFL 

       310        320        330        340        350        360 
AGAVPVVLGP NRTNYERFVP SNAFIHVDDF PSASSLAAHL QFLDRNPTVY RGYFRWRRSH 

       370        380        390 
AVHVTSFWDE PWCLACQAVQ KAGNQRKSVP NLAGWFQQ 

« Hide

References

[1]Javaud C., Julien R.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

AF531092 mRNA. Translation: AAN63882.1.
IPIIPI00697209.
RefSeqNP_777161.1.
UniGeneBt.12767

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT10. Glycosyltransferase Family 10.

Genome annotation databases

EnsemblENSBTAG00000038062. Bos taurus. [Contig view]
GeneID282854.
KEGGbta:282854.

Phylogenomic databases

HOVERGENQ8HZR3.

Family and domain databases

InterProIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERPTHR11929. Glyco_trans_10. 1 hit.
PfamPF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFUT4_BOVIN
AccessionPrimary (citable) accession number: Q8HZR3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: March 1, 2003
Last modified: June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents