Q8HZR2 (FUT9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-(1,3)-fucosyltransferase
EC=2.4.1.-

Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name=Fuc-TIX
Short name=FucT-IX
Galactoside 3-L-fucosyltransferase

Gene names

Name:

FUT9

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides By similarity.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein glycosylation Inferred from sequence or structural similarity. Source: AgBase
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alpha-(1->3)-fucosyltransferase activity Inferred from sequence or structural similarity. Source: AgBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Alpha-(1,3)-fucosyltransferase		PRO_0000221115
Regions
	Topological domain	1 – 11	11	Cytoplasmic Potential
	Transmembrane	12 – 32	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	33 – 359	327	Lumenal Potential
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8HZR2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: AD72DB86F8893626	FASTA	359	41,979
	10 20 30 40 50 60 MTSASKGILR PFLIVCIILA CSMVCLFIYI KPTNSWIFSP MESASSVLKM KNFFSTKTGD 70 80 90 100 110 120 FNETTILIWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY NKSHAVLIHH RDISWDLTNL 130 140 150 160 170 180 PQQARPPFQK WIWMNLESPT HTPQKSGIEH LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF 190 200 210 220 230 240 EVPNKEKLVC WVVSNWNPEH ARVKYYNELS KSIEIHTYGQ AFGEYVTDKN LIPTISTCKF 250 260 270 280 290 300 YLSFENSIHK DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK 310 320 330 340 350 YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV GNLEKWFWN

References

[1]	Javaud C., Julien R. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF531093 mRNA. Translation: AAN63883.1.
IPI	IPI00706125.
RefSeq	NP_777160.1. NM_174735.2.
UniGene	Bt.12766.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8HZR2.
Protein family/group databases
CAZy	GT10. Glycosyltransferase Family 10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	282853.
KEGG	bta:282853.
Organism-specific databases
CTD	10690.
Phylogenomic databases
eggNOG	maNOG08786.
GeneTree	ENSGT00550000074250.
HOVERGEN	HBG000274.
InParanoid	Q8HZR2.
OrthoDB	EOG412M5N.
Family and domain databases
InterPro	IPR001503. Glyco_trans_10. [Graphical view]
KO	K03663.
PANTHER	PTHR11929. Glyco_trans_10. 1 hit.
Pfam	PF00852. Glyco_transf_10. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT9_BOVIN

Accession

Primary (citable) accession number: Q8HZR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program