Q8HZR1 (Q8HZR1_CANFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Cyclooxygenase EMBL AAN33049.1
Organism	Canis familiaris (Dog) (Canis lupus familiaris) EMBL AAN33049.1
Taxonomic identifier	9615 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	633 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8HZR1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D338221B976BDB7E	FASTA	633	72,503
	10 20 30 40 50 60 MSREFDPEAP RNPLRLPGEP RMPGPALTSR SAGGSRLHRW PLLLLLLLLL PPPPVLPAEA 70 80 90 100 110 120 RTPAPVNPCC YYPCQHQGIC VRFGLDRYQC DCTRTGYSGP NCTIPELWTW LRNSLRPSPS 130 140 150 160 170 180 FLHFLLTHGR WFWEFINATF IRDMLMRLVL TARSNLIPSP PTYNIAHDYI SWESFSNVSY 190 200 210 220 230 240 YTRVLPSVPQ DCPTPMGTKG KKQLPDAQLL GRRFLLRRKF IPDPQGTNLM FAFFAQHFTH 250 260 270 280 290 300 QFFKTSGKMG PGFTKALGHG VDLGHIYGDN LDRQYQLRLF KDGKLKYQVL DGEMYPPSVE 310 320 330 340 350 360 EAPVLMHYPR GILPQSQMAV GQEVFGLLPG LMLYATLWLR EHNRVCDLLK AEHPTWGDEQ 370 380 390 400 410 420 LFQTARLILI GETIKIVIEE YVQQLSGYFL QLKFDPELLF SAQFQYRNRI AMEFNQLYHW 430 440 450 460 470 480 HPLMPDSFWV GSQEYSYEQF LFNTSMLTHY GIEALVDAFS RQSAGRIGGG RNIDHHVLHV 490 500 510 520 530 540 AVETIKESRE LRLQPFNEYR KRFGMRPYMS FQELTGEKEM AAELEELYGD IDALEFYPGL 550 560 570 580 590 600 LLEKCHPNSI FGESMIEIGA PFSLKGLLGN PICSPEYWKP STFGGEMGFN MVKTATLKKL 610 620 630 VCLNTKTCPY VSFRVPDPHQ DGGPGVQRPS TEL

References

[1]

"COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression." Chandrasekharan N.V., Dai H., Roos K.L., Evanson N.K., Tomsik J., Elton T.S., Simmons D.L. Proc. Natl. Acad. Sci. U.S.A. 99:13926-13931(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF535138 mRNA. Translation: AAN33049.1.
RefSeq	NP_001003023.1. NM_001003023.2.
UniGene	Cfa.61.
3D structure databases
HSSP	HSSP built from PDB template 1Q4G based on UniProtKB P05979.
ProteinModelPortal	Q8HZR1.
SMR	Q8HZR1. Positions 65-617.
ModBase	Search...
Protein family/group databases
PeroxiBase	3362. CfaPGHS01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403544.
KEGG	cfa:403544.
Organism-specific databases
CTD	5742.
Phylogenomic databases
HOGENOM	HOG000013149.
HOVERGEN	HBG000366.
InParanoid	Q8HZR1.
KO	K00509.
OrthoDB	EOG402WRZ.
Family and domain databases
Gene3D	1.10.640.10. 1 hit.
InterPro	IPR000742. EG-like_dom. IPR010255. Haem_peroxidase. IPR002007. Haem_peroxidase_animal. IPR019791. Haem_peroxidase_animal_subgr. [Graphical view]
Pfam	PF03098. An_peroxidase. 2 hits. [Graphical view]
PRINTS	PR00457. ANPEROXIDASE.
SMART	SM00181. EGF. 1 hit. [Graphical view]
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS50026. EGF_3. 1 hit. PS50292. PEROXIDASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL4133.
NextBio	20817054.

Entry information

Entry name

Q8HZR1_CANFA

Accession

Primary (citable) accession number: Q8HZR1

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)