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Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 110ExtracellularSequence analysisAdd BLAST17
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini132 – 153CytoplasmicSequence analysisAdd BLAST22
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 206ExtracellularSequence analysisAdd BLAST32
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 250CytoplasmicSequence analysisAdd BLAST23
Transmembranei251 – 271Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini272 – 294ExtracellularSequence analysisAdd BLAST23
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 352CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1250405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691831 – 352B1 bradykinin receptorAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 188PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Lipidationi329S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000032596.

Chemistry databases

BindingDBiQ8HZP2.

Structurei

3D structure databases

ProteinModelPortaliQ8HZP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG103183.
InParanoidiQ8HZP2.
KOiK03915.

Family and domain databases

InterProiView protein in InterPro
IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8HZP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASWPPLELQ SSNQSQLFPQ NATACDNAPE AWDLLHRVLP TFIISICSFG
60 70 80 90 100
LLGNLFVLLV FLLPRRRLNV AEIYLANLAA SDLVFVLGLP FWAENIWNQF
110 120 130 140 150
NWPFGALLCR VINGIIKANL FISIFLVVAI SQDRYCVLVH PMASRRRQRR
160 170 180 190 200
RQARVTCVLI WVVGGLLSIP TFLLRSIQAV PDLNITACIL LLPHEAWHFA
210 220 230 240 250
RIVELNILAF LLPLAAIIFF NYHILASLRG REEVSRTRCG GSKDSKTTAL
260 270 280 290 300
ILTLVVAFLV CWAPYHFFAF LEFLFQVQAV RGCFWEDFID LGLQLANFLA
310 320 330 340 350
FTNSSLNPVI YVFVGRLFRT KVWELYKQCT PKSLAPISSS HRKEIFQLFW

RN
Length:352
Mass (Da):40,246
Last modified:March 1, 2003 - v1
Checksum:i9254149620ED896D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8E → Q in AAK95386 (Ref. 2) Curated1
Sequence conflicti314V → A in AAK95386 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540785 Genomic DNA. Translation: AAN16464.1.
AY045568 Genomic DNA. Translation: AAK95386.1.
RefSeqiXP_014999945.1. XM_015144459.1.

Genome annotation databases

GeneIDi712251.
KEGGimcc:712251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540785 Genomic DNA. Translation: AAN16464.1.
AY045568 Genomic DNA. Translation: AAK95386.1.
RefSeqiXP_014999945.1. XM_015144459.1.

3D structure databases

ProteinModelPortaliQ8HZP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000032596.

Chemistry databases

BindingDBiQ8HZP2.
ChEMBLiCHEMBL1250405.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi712251.
KEGGimcc:712251.

Organism-specific databases

CTDi623.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG103183.
InParanoidiQ8HZP2.
KOiK03915.

Family and domain databases

InterProiView protein in InterPro
IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBKRB1_MACMU
AccessioniPrimary (citable) accession number: Q8HZP2
Secondary accession number(s): Q95L02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: March 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.