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Protein

Syndecan-4

Gene

SDC4

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-4
Short name:
SYND4
Gene namesi
Name:SDC4
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 152ExtracellularSequence analysisAdd BLAST130
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 202CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029010823 – 202Syndecan-4Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43O-linked (Xyl...) (heparan sulfate) serineBy similarity1
Glycosylationi65O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi67O-linked (Xyl...) (heparan sulfate) serineSequence analysis1

Post-translational modificationi

Shedding, cleavage of the extracellular domain to release a soluble form, is enhanced by a number of factors such as heparanase, growth factor receptor action for example by thrombin or EGF. Physiological events such as stress or wound healing can activate the shedding. PMA-mediated shedding is inhibited by TIMP3 (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

PaxDbiQ8HZJ6.

Interactioni

Subunit structurei

Homodimer. Interacts with CDCP1 and SDCBP. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007885.

Structurei

3D structure databases

ProteinModelPortaliQ8HZJ6.
SMRiQ8HZJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiQ8HZJ6.
KOiK16338.
OrthoDBiEOG091G0OOE.

Family and domain databases

InterProiView protein in InterPro
IPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiView protein in Pfam
PF01034. Syndecan. 1 hit.
SMARTiView protein in SMART
SM00294. 4.1m. 1 hit.
PROSITEiView protein in PROSITE
PS00964. SYNDECAN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HZJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRLLALL LLLVGAFNAA AAESIRETEV INPQDLLEGR YFSGDLPDDE
60 70 80 90 100
DVGGPGQEPD DFEWSGSGDL EGPEDKHMLP EVTHPLVPLD NHIPERTGPG
110 120 130 140 150
GRVPTEPKEL EENEVIPKRM SPFDGDEDVS NKVSMSSTAQ GSNIFERTEV
160 170 180 190 200
LSALIVGGIV GILFAVFLVL LLVYRMKKKD EGSYDLGKKP IYKKAPTNEF

YA
Length:202
Mass (Da):22,081
Last modified:March 1, 2003 - v1
Checksum:i107CA9BEE5673C2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548542 mRNA. Translation: AAN59952.1.
RefSeqiNP_999449.1. NM_214284.1.
UniGeneiSsc.16324.

Genome annotation databases

EnsembliENSSSCT00000049336; ENSSSCP00000048536; ENSSSCG00000038594.
GeneIDi397528.
KEGGissc:397528.

Similar proteinsi

Entry informationi

Entry nameiSDC4_PIG
AccessioniPrimary (citable) accession number: Q8HZJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families