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Protein

Syndecan-4

Gene

SDC4

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-4
Short name:
SYND4
Gene namesi
Name:SDC4
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

  • Membrane Sequence analysis; Single-pass type I membrane protein Sequence analysis
  • Secreted By similarity

  • Note: Shedding of the ectodomain produces a soluble form.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 152ExtracellularSequence analysisAdd BLAST130
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 202CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029010823 – 202Syndecan-4Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43O-linked (Xyl...) (heparan sulfate)By similarity1
Glycosylationi65O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi67O-linked (Xyl...) (heparan sulfate)Sequence analysis1

Post-translational modificationi

Shedding, cleavage of the extracellular domain to release a soluble form, is enhanced by a number of factors such as heparanase, growth factor receptor action for example by thrombin or EGF. Physiological events such as stress or wound healing can activate the shedding. PMA-mediated shedding is inhibited by TIMP3 (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

PaxDbiQ8HZJ6.

Expressioni

Gene expression databases

BgeeiENSSSCG00000007401.

Interactioni

Subunit structurei

Homodimer. Interacts with CDCP1 and SDCBP. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007885.

Structurei

3D structure databases

ProteinModelPortaliQ8HZJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiQ8HZJ6.
KOiK16338.
OrthoDBiEOG091G0OOE.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HZJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRLLALL LLLVGAFNAA AAESIRETEV INPQDLLEGR YFSGDLPDDE
60 70 80 90 100
DVGGPGQEPD DFEWSGSGDL EGPEDKHMLP EVTHPLVPLD NHIPERTGPG
110 120 130 140 150
GRVPTEPKEL EENEVIPKRM SPFDGDEDVS NKVSMSSTAQ GSNIFERTEV
160 170 180 190 200
LSALIVGGIV GILFAVFLVL LLVYRMKKKD EGSYDLGKKP IYKKAPTNEF

YA
Length:202
Mass (Da):22,081
Last modified:March 1, 2003 - v1
Checksum:i107CA9BEE5673C2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548542 mRNA. Translation: AAN59952.1.
RefSeqiNP_999449.1. NM_214284.1.
UniGeneiSsc.16324.

Genome annotation databases

GeneIDi397528.
KEGGissc:397528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548542 mRNA. Translation: AAN59952.1.
RefSeqiNP_999449.1. NM_214284.1.
UniGeneiSsc.16324.

3D structure databases

ProteinModelPortaliQ8HZJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007885.

Proteomic databases

PaxDbiQ8HZJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397528.
KEGGissc:397528.

Organism-specific databases

CTDi6385.

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiQ8HZJ6.
KOiK16338.
OrthoDBiEOG091G0OOE.

Gene expression databases

BgeeiENSSSCG00000007401.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDC4_PIG
AccessioniPrimary (citable) accession number: Q8HZJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 1, 2003
Last modified: October 5, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.