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Protein

Trace amine-associated receptor 1

Gene

TAAR1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 1
Short name:
TaR-1
Short name:
Trace amine receptor 1
Gene namesi
Name:TAAR1
Synonyms:TA1, TAR1, TRAR1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 58CytoplasmicSequence analysisAdd BLAST13
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 97ExtracellularSequence analysisAdd BLAST18
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 135CytoplasmicSequence analysisAdd BLAST17
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 187ExtracellularSequence analysisAdd BLAST31
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 251CytoplasmicSequence analysisAdd BLAST43
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 286ExtracellularSequence analysisAdd BLAST14
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 338CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1926495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701421 – 338Trace amine-associated receptor 1Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000015088.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000019771.

Chemistry databases

BindingDBiQ8HZ64.

Structurei

3D structure databases

ProteinModelPortaliQ8HZ64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ8HZ64.
KOiK05051.
OMAiGAEEMYY.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HZ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFCHNIINI SCVKNNWSND VRASLYSLMA LIILTTLVGN LIVIVSISHF
60 70 80 90 100
KQLHTPTNWL IHSMATVDFL LGCLVMPYSM VRSAEHCWYF GEVFCKIHTS
110 120 130 140 150
TDIMLSSASI FHLSFISIDR YYAVCDPLRY KAKINILVVC VMIFISWSVP
160 170 180 190 200
AVFAFGMIFL ELNFKGAEEI YYKHVHCRGG CSVFFSKISG VLAFMTSFYI
210 220 230 240 250
PGSIMLCIYY RIYLIAKEQA RSINDANQKL QIGLEMKNGI SQSKERKAVK
260 270 280 290 300
TLGIVMGVFL ICWCPFFVCT VIDPFLHYTI PPTLNDVLIW FGYLNSTFNP
310 320 330
MVYAFFYPWF RKALKMILFG KIFQKDSSRC KLFLESSS
Length:338
Mass (Da):38,797
Last modified:March 1, 2003 - v1
Checksum:i9EE7B35456BB409B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135366 Genomic DNA. Translation: AAN06172.1.
RefSeqiNP_001074234.1. NM_001080765.1.
UniGeneiMmu.16488.

Genome annotation databases

GeneIDi708944.
KEGGimcc:708944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135366 Genomic DNA. Translation: AAN06172.1.
RefSeqiNP_001074234.1. NM_001080765.1.
UniGeneiMmu.16488.

3D structure databases

ProteinModelPortaliQ8HZ64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000019771.

Chemistry databases

BindingDBiQ8HZ64.
ChEMBLiCHEMBL1926495.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi708944.
KEGGimcc:708944.

Organism-specific databases

CTDi134864.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ8HZ64.
KOiK05051.
OMAiGAEEMYY.

Miscellaneous databases

PROiQ8HZ64.

Gene expression databases

BgeeiENSMMUG00000015088.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR1_MACMU
AccessioniPrimary (citable) accession number: Q8HZ64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.