Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Osteocalcin

Gene

BGLAP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Calcium 3By similarity
Metal bindingi21 – 211Calcium 2By similarity
Metal bindingi24 – 241Calcium 1By similarity
Metal bindingi24 – 241Calcium 2By similarity
Metal bindingi30 – 301Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-159740. Gamma-carboxylation of protein precursors.
R-SSC-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-SSC-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4949OsteocalcinPRO_0000148903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Hydroxyproline1 Publication
Modified residuei17 – 1714-carboxyglutamatePROSITE-ProRule annotation2 Publications
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation2 Publications
Disulfide bondi23 ↔ 29PROSITE-ProRule annotation1 Publication
Modified residuei24 – 2414-carboxyglutamatePROSITE-ProRule annotation2 Publications

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation2 Publications

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Proteomic databases

PaxDbiQ8HYY9.

Expressioni

Gene expression databases

GenevisibleiQ8HYY9. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006919.

Structurei

Secondary structure

1
49
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 259Combined sources
Helixi27 – 3610Combined sources
Helixi38 – 469Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q8HX-ray2.00A1-49[»]
ProteinModelPortaliQ8HYY9.
SMRiQ8HYY9. Positions 13-49.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8HYY9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
InParanoidiQ8HYY9.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HYY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
YLDHGLGAPA PYPDPLEPRR EVCELNPDCD ELADHIGFQE AYRRFYGIA
Length:49
Mass (Da):5,591
Last modified:July 5, 2005 - v2
Checksum:iBABF16015806D42F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150038 mRNA. Translation: AAN73020.1.
UniGeneiSsc.16326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150038 mRNA. Translation: AAN73020.1.
UniGeneiSsc.16326.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q8HX-ray2.00A1-49[»]
ProteinModelPortaliQ8HYY9.
SMRiQ8HYY9. Positions 13-49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006919.

Proteomic databases

PaxDbiQ8HYY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
InParanoidiQ8HYY9.

Enzyme and pathway databases

ReactomeiR-SSC-159740. Gamma-carboxylation of protein precursors.
R-SSC-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-SSC-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Miscellaneous databases

EvolutionaryTraceiQ8HYY9.

Gene expression databases

GenevisibleiQ8HYY9. SS.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The amino acid sequences of goat, pig and wallaby osteocalcins."
    Huq N.L., Teh L.-C., Christie D.L., Chapman G.E.
    Biochem. Int. 8:521-527(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, GAMMA-CARBOXYGLUTAMATION AT GLU-17; GLU-21 AND GLU-24.
    Tissue: Bone.
  2. "Identification of Sus scrofa osteocalcin by comparative genomics."
    Laize V., Cancela M.L.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-49.
  3. "Bone recognition mechanism of porcine osteocalcin from crystal structure."
    Hoang Q.Q., Sicheri F., Howard A.J., Yang D.S.C.
    Nature 425:977-980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), GAMMA-CARBOXYGLUTAMATION AT GLU-17; GLU-21 AND GLU-24, DISULFIDE BOND.

Entry informationi

Entry nameiOSTCN_PIG
AccessioniPrimary (citable) accession number: Q8HYY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 11, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.