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Protein

Osteocalcin

Gene

BGLAP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Calcium 3By similarity
Metal bindingi21 – 211Calcium 2By similarity
Metal bindingi24 – 241Calcium 1By similarity
Metal bindingi24 – 241Calcium 2By similarity
Metal bindingi30 – 301Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4949OsteocalcinPRO_0000148903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Hydroxyproline1 Publication
Modified residuei17 – 1714-carboxyglutamatePROSITE-ProRule annotation2 Publications
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation2 Publications
Disulfide bondi23 ↔ 29PROSITE-ProRule annotation1 Publication
Modified residuei24 – 2414-carboxyglutamatePROSITE-ProRule annotation2 Publications

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation2 Publications

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Proteomic databases

PaxDbiQ8HYY9.

Expressioni

Gene expression databases

GenevisibleiQ8HYY9. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006919.

Structurei

Secondary structure

1
49
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 259Combined sources
Helixi27 – 3610Combined sources
Helixi38 – 469Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q8HX-ray2.00A1-49[»]
ProteinModelPortaliQ8HYY9.
SMRiQ8HYY9. Positions 13-49.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8HYY9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
InParanoidiQ8HYY9.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HYY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
YLDHGLGAPA PYPDPLEPRR EVCELNPDCD ELADHIGFQE AYRRFYGIA
Length:49
Mass (Da):5,591
Last modified:July 5, 2005 - v2
Checksum:iBABF16015806D42F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150038 mRNA. Translation: AAN73020.1.
UniGeneiSsc.16326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150038 mRNA. Translation: AAN73020.1.
UniGeneiSsc.16326.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q8HX-ray2.00A1-49[»]
ProteinModelPortaliQ8HYY9.
SMRiQ8HYY9. Positions 13-49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006919.

Proteomic databases

PaxDbiQ8HYY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
InParanoidiQ8HYY9.

Miscellaneous databases

EvolutionaryTraceiQ8HYY9.

Gene expression databases

GenevisibleiQ8HYY9. SS.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The amino acid sequences of goat, pig and wallaby osteocalcins."
    Huq N.L., Teh L.-C., Christie D.L., Chapman G.E.
    Biochem. Int. 8:521-527(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, GAMMA-CARBOXYGLUTAMATION AT GLU-17; GLU-21 AND GLU-24.
    Tissue: Bone.
  2. "Identification of Sus scrofa osteocalcin by comparative genomics."
    Laize V., Cancela M.L.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-49.
  3. "Bone recognition mechanism of porcine osteocalcin from crystal structure."
    Hoang Q.Q., Sicheri F., Howard A.J., Yang D.S.C.
    Nature 425:977-980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), GAMMA-CARBOXYGLUTAMATION AT GLU-17; GLU-21 AND GLU-24, DISULFIDE BOND.

Entry informationi

Entry nameiOSTCN_PIG
AccessioniPrimary (citable) accession number: Q8HYY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.