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Protein

Uveal autoantigen with coiled-coil domains and ankyrin repeats protein

Gene

UACA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).By similarity
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury (PubMed:11950601, PubMed:14517325). May be involved in multiple neurite formation (By similarity).By similarity2 Publications

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uveal autoantigen with coiled-coil domains and ankyrin repeats protein
Alternative name(s):
Beta-actin-binding protein
BetaCAP73
Gene namesi
Name:UACA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002316481 – 1401Uveal autoantigen with coiled-coil domains and ankyrin repeats proteinAdd BLAST1401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineBy similarity1
Cross-linki1020Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8HYY4.
PRIDEiQ8HYY4.

Expressioni

Tissue specificityi

Highly expressed in muscle and heart, moderately in liver, kidney and pancreas, and weakly in placenta and lung.1 Publication

Inductioni

Down-regulated in crawling cells. Up-regulated in motility-defective cells.1 Publication

Interactioni

Subunit structurei

Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3 (By similarity). Interacts with ARF6 and ACTB. Interacts with RAB39A (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018584.

Structurei

3D structure databases

ProteinModelPortaliQ8HYY4.
SMRiQ8HYY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 53ANK 1Add BLAST29
Repeati54 – 83ANK 2Add BLAST30
Repeati87 – 116ANK 3Add BLAST30
Repeati120 – 149ANK 4Add BLAST30
Repeati153 – 182ANK 5Add BLAST30
Repeati186 – 215ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili273 – 361Sequence analysisAdd BLAST89
Coiled coili423 – 827Sequence analysisAdd BLAST405
Coiled coili856 – 1368Sequence analysisAdd BLAST513

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IJC6. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000147885.
HOVERGENiHBG066395.
InParanoidiQ8HYY4.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR030227. UACA.
PANTHERiPTHR24173:SF23. PTHR24173:SF23. 3 hits.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 6 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.

Sequencei

Sequence statusi: Complete.

Q8HYY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSCWFSCAP KNRQAADWNK YDDRLMRAAE RGDVEKVSSI LAKKGVNPGK
60 70 80 90 100
LDVEGRSAFH VVASKGNLEC LNAILIHGVD ITTSDTAGRN ALHLAAKYGH
110 120 130 140 150
ALCLQKLLQY NCPTEHVDLQ GRTALHDAAM ADCPSSIQLL CDHGASVNAK
160 170 180 190 200
DVDGRTPLVL ATQMCRPTIC QLLIDRGADI NSRDKQNRTA LMLGCEYGCK
210 220 230 240 250
DAVEVLIKNG ADVTLLDALG HDSSYYARIG DNLDILTLLK TASENSNKGR
260 270 280 290 300
ELWKKGPSLQ QRNLSQMLDE VNTKSNQREH QNIQDLEIEN EDLKERLRKI
310 320 330 340 350
QQEQRILLDK VNGLQLQLNE EVMVADDLES EKEKLKSLLA AKEKQHEESL
360 370 380 390 400
RTIEALKSRF KYFESDHLGS GSHFRKEDML LKQGQMYMTD SQCTSTGMPV
410 420 430 440 450
HMQSRSMLRP LELALPNQAS YSENEILKKE LEAMRTFCDS AKQDRLKLQN
460 470 480 490 500
ELAHKVAECK ALALECERVK EDSDEQIKQL EDALKDVQKR MYESEGKVKQ
510 520 530 540 550
MQTHFLALKE HLTSDAATGN HRLMEELKDQ LKDMKVKYEG ASAEVGKLRN
560 570 580 590 600
QIKQNEMLVE EFKRDEGKLM EENKRLQKEL SMCELEREKR GRKLTEMEGQ
610 620 630 640 650
LKDLSAKLAL SIPAEKFENM KSLLSNELNE KAKKLIDVER EYERSLNETR
660 670 680 690 700
PLKRELENLK AKLAQHVKPE EHEQLKSRLE QKSGELGKRI TELTSKNQTL
710 720 730 740 750
QKEIEKVCLD NKLLTQQVNN LTTEMKNHYV PLKVSEEMKK SHDVIVDDLN
760 770 780 790 800
KKLSDVTHKY TEKKLEMEKL LMENASLSKN VSRLETVFIP PERHEKEMMA
810 820 830 840 850
LKSNITELKK QLSELNKKCG EDQEKIYSLM SENNDLKKTM SHQYVPVKTH
860 870 880 890 900
EEIKTALSST LDKTNRELVD VKKKCEDINQ EFVKIKDENE ILKRNLENTQ
910 920 930 940 950
NQVKAEYISL REHEEKMSGL RKSMKKVQDN SAEILAKYKK SQEEIVTLHE
960 970 980 990 1000
EIAAQKRELD TIQECIKLKY APIISLEECE RKFKATEKEL KEQLSQQTQK
1010 1020 1030 1040 1050
YNTSEEEAKK CKQENDKLKK EILTLQKDLK DKNVHIENSY ETERALSRKT
1060 1070 1080 1090 1100
EELNRQLKDL LQKYTEAKKE KEKLVEENAK QTSEILAAQT LLQKQHVPLE
1110 1120 1130 1140 1150
QVESLKKSLS GTIETLKEEL KTKQRCYEKE QQTVTQLRQM LENQKNSSVP
1160 1170 1180 1190 1200
LAEHLQVKEA FEKEVGIIKA SLREKEEESQ NKTEEVSKLQ SEIQNTKQAL
1210 1220 1230 1240 1250
KKLETREVVD LSKYKATKSD LETQISDLNE KLANLNRKYE EVCEEVLHAK
1260 1270 1280 1290 1300
KKELSAKDEK ELLHFSIEQE IKDQQERCDK SLTTITELQR RIQESAKQIE
1310 1320 1330 1340 1350
AKDNKITELL NDVERLKQAL NGLSQLTYGS GSPSKRQSQL IDSLQQQVRS
1360 1370 1380 1390 1400
LQQQLADADR QHQEVIAIYR THLLSAAQGH MDEDVQAALL QIIQMRQGLV

C
Length:1,401
Mass (Da):161,299
Last modified:March 1, 2003 - v1
Checksum:i429312A3F658546A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152693 mRNA. Translation: AAN74017.1.
RefSeqiNP_776634.1. NM_174209.2.
UniGeneiBt.26227.

Genome annotation databases

GeneIDi281559.
KEGGibta:281559.

Similar proteinsi

Entry informationi

Entry nameiUACA_BOVIN
AccessioniPrimary (citable) accession number: Q8HYY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome