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Protein

Solute carrier organic anion transporter family member 3A1

Gene

SLCO3A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 3A1
Alternative name(s):
Organic anion-transporting polypeptide D
Short name:
OATP-D
Gene namesi
Name:SLCO3A1
Synonyms:OATP3A1, OATPD, SLC21A11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6020Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini61 – 7919ExtracellularSequence analysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 1066CytoplasmicSequence analysis
Transmembranei107 – 13125Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini132 – 17443ExtracellularSequence analysisAdd
BLAST
Transmembranei175 – 20329Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini204 – 22219CytoplasmicSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 26118ExtracellularSequence analysisAdd
BLAST
Transmembranei262 – 28625Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 34458CytoplasmicSequence analysisAdd
BLAST
Transmembranei345 – 36622Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini367 – 38620ExtracellularSequence analysisAdd
BLAST
Transmembranei387 – 41024Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini411 – 4144CytoplasmicSequence analysis
Transmembranei415 – 43824Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini439 – 539101ExtracellularSequence analysisAdd
BLAST
Transmembranei540 – 56223Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini563 – 5719CytoplasmicSequence analysis
Transmembranei572 – 59726Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini598 – 63033ExtracellularSequence analysisAdd
BLAST
Transmembranei631 – 64818Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini649 – 70557CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Solute carrier organic anion transporter family member 3A1PRO_0000369263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8HYW2.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002169.

Structurei

3D structure databases

ProteinModelPortaliQ8HYW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini465 – 51349Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
InParanoidiQ8HYW2.
KOiK14353.
OMAiLKSSAFV.
OrthoDBiEOG7GQXV6.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8HYW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
60 70 80 90 100
LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
110 120 130 140 150
ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
160 170 180 190 200
AANGSGGDQG PDPDLICRSR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
210 220 230 240 250
YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
260 270 280 290 300
LDITPDDPRW IGAWWGGFLL CGALLFFSSV LMFGFPQSLP PHSDPALESE
310 320 330 340 350
QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
360 370 380 390 400
FTCIILAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
410 420 430 440 450
LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG
460 470 480 490 500
VTVPYGNSST PGSALDPYSS CNKNCECQTD SFTPVCGADG ITYLSACFAG
510 520 530 540 550
CNSTNLTGCA CLMTIPPENA TVIPGKCPSP GCQEAFLTFL CVMCVCSMIG
560 570 580 590 600
AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
610 620 630 640 650
CLFWSTFCGE QGACALYDNV AYRYLYVSIA IALKSFAFLL YTTTWQCLRK
660 670 680 690 700
NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH
710
EWCENMESVL
Length:710
Mass (Da):76,555
Last modified:March 1, 2003 - v1
Checksum:i1FE677A88523A21C
GO
Isoform 2 (identifier: Q8HYW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-692: EFFASTLTLDNLGRDPVPANQTHRTK → TEYQDIETEKTCPESQSPSEDSFVRS
     693-710: Missing.

Show »
Length:692
Mass (Da):74,365
Checksum:i0F9D8D704EF6C2AF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei667 – 69226EFFAS…THRTK → TEYQDIETEKTCPESQSPSE DSFVRS in isoform 2. 1 PublicationVSP_036845Add
BLAST
Alternative sequencei693 – 71018Missing in isoform 2. 1 PublicationVSP_036846Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508719 mRNA. Translation: CAD48488.1.
BC123736 mRNA. Translation: AAI23737.1.
RefSeqiNP_001001134.1. NM_001001134.1. [Q8HYW2-1]
XP_005221768.1. XM_005221711.3. [Q8HYW2-2]
UniGeneiBt.27973.

Genome annotation databases

EnsembliENSBTAT00000002169; ENSBTAP00000002169; ENSBTAG00000001652. [Q8HYW2-1]
ENSBTAT00000055950; ENSBTAP00000047887; ENSBTAG00000001652. [Q8HYW2-2]
GeneIDi407132.
KEGGibta:407132.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508719 mRNA. Translation: CAD48488.1.
BC123736 mRNA. Translation: AAI23737.1.
RefSeqiNP_001001134.1. NM_001001134.1. [Q8HYW2-1]
XP_005221768.1. XM_005221711.3. [Q8HYW2-2]
UniGeneiBt.27973.

3D structure databases

ProteinModelPortaliQ8HYW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002169.

Proteomic databases

PaxDbiQ8HYW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002169; ENSBTAP00000002169; ENSBTAG00000001652. [Q8HYW2-1]
ENSBTAT00000055950; ENSBTAP00000047887; ENSBTAG00000001652. [Q8HYW2-2]
GeneIDi407132.
KEGGibta:407132.

Organism-specific databases

CTDi28232.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
InParanoidiQ8HYW2.
KOiK14353.
OMAiLKSSAFV.
OrthoDBiEOG7GQXV6.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-BTA-879518. Transport of organic anions.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new member of the OATP superfamily from bovine kidney (Oatp 3a1)."
    Geyer J., Petzinger E.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSO3A1_BOVIN
AccessioniPrimary (citable) accession number: Q8HYW2
Secondary accession number(s): A4FV49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.