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Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. chemokine-mediated signaling pathway Source: UniProtKB
  3. G-protein coupled receptor signaling pathway Source: UniProtKB
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. regulation of insulin secretion Source: UniProtKB
  7. regulation of neuron death Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026835.

Structurei

3D structure databases

ProteinModelPortaliQ8HYS0.
SMRiQ8HYS0. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYS0.
KOiK12499.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAATFAI LLATATFRAP ASASPYASDT TPCCFAYISG RLPFTHVQEY
60 70 80 90
FYTSSKCSMP AVVFVTRKHR QVCANPQKKW VREYINSLEM S
Length:91
Mass (Da):10,179
Last modified:March 1, 2003 - v1
Checksum:i01D79538CB8148E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098562 mRNA. Translation: BAC53725.1.
RefSeqiNP_001003010.1. NM_001003010.2.
UniGeneiCfa.21.

Genome annotation databases

GeneIDi403522.
KEGGicfa:403522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098562 mRNA. Translation: BAC53725.1.
RefSeqiNP_001003010.1. NM_001003010.2.
UniGeneiCfa.21.

3D structure databases

ProteinModelPortaliQ8HYS0.
SMRiQ8HYS0. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403522.
KEGGicfa:403522.

Organism-specific databases

CTDi6352.

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYS0.
KOiK12499.

Miscellaneous databases

NextBioi20817033.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of canine RANTES gene."
    Enomoto A., Kano R., Hasegawa A.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL5_CANFA
AccessioniPrimary (citable) accession number: Q8HYS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.