Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8HYQ3

- CCL3_MACMU

UniProt

Q8HYQ3 - CCL3_MACMU

Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei40 – 401Involved in GAG bindingBy similarity
    Sitei68 – 681Involved in GAG bindingBy similarity
    Sitei70 – 701Involved in GAG bindingBy similarity

    GO - Molecular functioni

    1. calcium-dependent protein kinase C activity Source: UniProtKB
    2. chemoattractant activity Source: UniProtKB
    3. chemokine activity Source: UniProtKB
    4. kinase activity Source: UniProtKB
    5. phospholipase activator activity Source: UniProtKB
    6. protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. astrocyte cell migration Source: UniProtKB
    2. behavior Source: UniProtKB
    3. calcium ion transport Source: UniProtKB
    4. calcium-mediated signaling Source: UniProtKB
    5. cell activation Source: UniProtKB
    6. cell-cell signaling Source: UniProtKB
    7. cellular calcium ion homeostasis Source: UniProtKB
    8. cellular response to organic cyclic compound Source: UniProtKB
    9. chemotaxis Source: UniProtKB
    10. cytoskeleton organization Source: UniProtKB
    11. eosinophil chemotaxis Source: UniProtKB
    12. eosinophil degranulation Source: UniProtKB
    13. exocytosis Source: UniProtKB
    14. granulocyte chemotaxis Source: UniProtKB
    15. inflammatory response Source: UniProtKB
    16. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    17. lymphocyte chemotaxis Source: UniProtKB
    18. macrophage chemotaxis Source: UniProtKB
    19. MAPK cascade Source: UniProtKB
    20. monocyte chemotaxis Source: UniProtKB
    21. negative regulation by host of viral transcription Source: UniProtKB
    22. negative regulation of gene expression Source: UniProtKB
    23. negative regulation of osteoclast differentiation Source: UniProtKB
    24. neutrophil chemotaxis Source: UniProtKB
    25. osteoblast differentiation Source: UniProtKB
    26. positive chemotaxis Source: GOC
    27. positive regulation of calcium ion transport Source: UniProtKB
    28. positive regulation of calcium-mediated signaling Source: UniProtKB
    29. positive regulation of catalytic activity Source: GOC
    30. positive regulation of cell migration Source: UniProtKB
    31. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    32. positive regulation of gene expression Source: UniProtKB
    33. positive regulation of inflammatory response Source: UniProtKB
    34. positive regulation of interleukin-1 beta secretion Source: UniProtKB
    35. positive regulation of natural killer cell chemotaxis Source: UniProtKB
    36. positive regulation of neuron apoptotic process Source: UniProtKB
    37. positive regulation of tumor necrosis factor production Source: UniProtKB
    38. protein kinase B signaling Source: UniProtKB
    39. protein phosphorylation Source: UniProtKB
    40. regulation of cell shape Source: UniProtKB
    41. regulation of sensory perception of pain Source: UniProtKB
    42. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
    43. response to cholesterol Source: UniProtKB
    44. response to toxic substance Source: UniProtKB
    45. signaling Source: UniProtKB
    46. T cell chemotaxis Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 3
    Alternative name(s):
    Macrophage inflammatory protein 1-alpha
    Short name:
    MIP-1-alpha
    Small-inducible cytokine A3
    Gene namesi
    Name:CCL3
    Synonyms:MIP1A
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 16

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. intracellular Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 9266C-C motif chemokine 3PRO_0000042848Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Self-associates.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HYQ3.
    SMRiQ8HYQ3. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG304839.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8HYQ3.
    KOiK05408.
    OMAiPTACCFF.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HYQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVSTAALAV LLCTVALCNR ISATFAADTP TSCCFSYISR QIPQNFIADY   50
    FETNSQCSKP GVIFLTKRGR QVCADPSKEW VQKYVSDLEL SA 92
    Length:92
    Mass (Da):10,120
    Last modified:March 1, 2003 - v1
    Checksum:i021CAA371143D12A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321S → A in AAN76985. (PubMed:12079558)Curated
    Sequence conflicti38 – 381I → T in AAN76985. (PubMed:12079558)Curated
    Sequence conflicti54 – 541N → S in AAN76985. (PubMed:12079558)Curated
    Sequence conflicti69 – 691G → S in AAN76985. (PubMed:12079558)Curated
    Sequence conflicti78 – 781K → E in AAN76985. (PubMed:12079558)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449266 mRNA. Translation: AAN76070.1.
    AF457195 mRNA. Translation: AAN76985.1.
    RefSeqiNP_001029372.1. NM_001034200.1.
    UniGeneiMmu.3703.

    Genome annotation databases

    EnsembliENSMMUT00000001343; ENSMMUP00000001262; ENSMMUG00000030216.
    GeneIDi619514.
    KEGGimcc:619514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449266 mRNA. Translation: AAN76070.1 .
    AF457195 mRNA. Translation: AAN76985.1 .
    RefSeqi NP_001029372.1. NM_001034200.1.
    UniGenei Mmu.3703.

    3D structure databases

    ProteinModelPortali Q8HYQ3.
    SMRi Q8HYQ3. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000001343 ; ENSMMUP00000001262 ; ENSMMUG00000030216 .
    GeneIDi 619514.
    KEGGi mcc:619514.

    Organism-specific databases

    CTDi 6348.

    Phylogenomic databases

    eggNOGi NOG304839.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8HYQ3.
    KOi K05408.
    OMAi PTACCFF.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 19980056.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
      Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
      Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
      Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
      AIDS Res. Hum. Retroviruses 18:627-639(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-85.

    Entry informationi

    Entry nameiCCL3_MACMU
    AccessioniPrimary (citable) accession number: Q8HYQ3
    Secondary accession number(s): Q8HYN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3