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Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei40Involved in GAG bindingBy similarity1
Sitei68Involved in GAG bindingBy similarity1
Sitei70Involved in GAG bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
Small-inducible cytokine A3
Gene namesi
Name:CCL3
Synonyms:MIP1A
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004284827 – 92C-C motif chemokine 3Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSMMUG00000030216

Interactioni

Subunit structurei

Self-associates.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001262

Structurei

3D structure databases

ProteinModelPortaliQ8HYQ3
SMRiQ8HYQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9 Eukaryota
ENOG410YXJU LUCA
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ8HYQ3
KOiK05408
OMAiNTPTACC
OrthoDBiEOG091G14Y2
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTVALCNR ISATFAADTP TSCCFSYISR QIPQNFIADY
60 70 80 90
FETNSQCSKP GVIFLTKRGR QVCADPSKEW VQKYVSDLEL SA
Length:92
Mass (Da):10,120
Last modified:March 1, 2003 - v1
Checksum:i021CAA371143D12A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → A in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti38I → T in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti54N → S in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti69G → S in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti78K → E in AAN76985 (PubMed:12079558).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449266 mRNA Translation: AAN76070.1
AF457195 mRNA Translation: AAN76985.1
RefSeqiNP_001029372.1, NM_001034200.1
UniGeneiMmu.3703

Genome annotation databases

GeneIDi619514
KEGGimcc:619514

Similar proteinsi

Entry informationi

Entry nameiCCL3_MACMU
AccessioniPrimary (citable) accession number: Q8HYQ3
Secondary accession number(s): Q8HYN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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