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Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei40Involved in GAG bindingBy similarity1
Sitei68Involved in GAG bindingBy similarity1
Sitei70Involved in GAG bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
Small-inducible cytokine A3
Gene namesi
Name:CCL3
Synonyms:MIP1A
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004284827 – 92C-C motif chemokine 3Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSMMUG00000030216.

Interactioni

Subunit structurei

Self-associates.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001262.

Structurei

3D structure databases

ProteinModelPortaliQ8HYQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ3.
KOiK05408.
OMAiNTPTACC.
OrthoDBiEOG091G14Y2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTVALCNR ISATFAADTP TSCCFSYISR QIPQNFIADY
60 70 80 90
FETNSQCSKP GVIFLTKRGR QVCADPSKEW VQKYVSDLEL SA
Length:92
Mass (Da):10,120
Last modified:March 1, 2003 - v1
Checksum:i021CAA371143D12A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → A in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti38I → T in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti54N → S in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti69G → S in AAN76985 (PubMed:12079558).Curated1
Sequence conflicti78K → E in AAN76985 (PubMed:12079558).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449266 mRNA. Translation: AAN76070.1.
AF457195 mRNA. Translation: AAN76985.1.
RefSeqiNP_001029372.1. NM_001034200.1.
UniGeneiMmu.3703.

Genome annotation databases

GeneIDi619514.
KEGGimcc:619514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449266 mRNA. Translation: AAN76070.1.
AF457195 mRNA. Translation: AAN76985.1.
RefSeqiNP_001029372.1. NM_001034200.1.
UniGeneiMmu.3703.

3D structure databases

ProteinModelPortaliQ8HYQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi619514.
KEGGimcc:619514.

Organism-specific databases

CTDi6348.

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ3.
KOiK05408.
OMAiNTPTACC.
OrthoDBiEOG091G14Y2.
TreeFamiTF334888.

Gene expression databases

BgeeiENSMMUG00000030216.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL3_MACMU
AccessioniPrimary (citable) accession number: Q8HYQ3
Secondary accession number(s): Q8HYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.