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Q8HYQ3 (CCL3_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name=MIP-1-alpha
Small-inducible cytokine A3
Gene names
Name:CCL3
Synonyms:MIP1A
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) By similarity.

Subunit structure

Self-associates By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from sequence or structural similarity. Source: UniProtKB

T cell chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

astrocyte cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

behavior

Inferred from sequence or structural similarity. Source: UniProtKB

calcium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

calcium-mediated signaling

Inferred from sequence or structural similarity. Source: UniProtKB

cell activation

Inferred from sequence or structural similarity. Source: UniProtKB

cell-cell signaling

Inferred from sequence or structural similarity. Source: UniProtKB

cellular calcium ion homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to organic cyclic compound

Inferred from sequence or structural similarity. Source: UniProtKB

chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

cytoskeleton organization

Inferred from sequence or structural similarity. Source: UniProtKB

eosinophil chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

eosinophil degranulation

Inferred from sequence or structural similarity. Source: UniProtKB

exocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

granulocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

lipopolysaccharide-mediated signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

lymphocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

macrophage chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

monocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation by host of viral transcription

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of osteoclast differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

neutrophil chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

osteoblast differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive chemotaxis

Inferred from sequence or structural similarity. Source: GOC

positive regulation of ERK1 and ERK2 cascade

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of calcium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of calcium-mediated signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of catalytic activity

Inferred from sequence or structural similarity. Source: GOC

positive regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of interleukin-1 beta secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of natural killer cell chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of neuron apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of tumor necrosis factor production

Inferred from sequence or structural similarity. Source: UniProtKB

protein kinase B signaling

Inferred from sequence or structural similarity. Source: UniProtKB

protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell shape

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of sensory perception of pain

Inferred from sequence or structural similarity. Source: UniProtKB

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProtKB

response to cholesterol

Inferred from sequence or structural similarity. Source: UniProtKB

response to toxic substance

Inferred from sequence or structural similarity. Source: UniProtKB

signaling

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from sequence or structural similarity. Source: UniProtKB

intracellular

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncalcium-dependent protein kinase C activity

Inferred from sequence or structural similarity. Source: UniProtKB

chemoattractant activity

Inferred from sequence or structural similarity. Source: UniProtKB

chemokine activity

Inferred from sequence or structural similarity. Source: UniProtKB

kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

phospholipase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 9266C-C motif chemokine 3
PRO_0000042848

Sites

Site401Involved in GAG binding By similarity
Site681Involved in GAG binding By similarity
Site701Involved in GAG binding By similarity

Amino acid modifications

Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 73 By similarity

Experimental info

Sequence conflict321S → A in AAN76985. Ref.2
Sequence conflict381I → T in AAN76985. Ref.2
Sequence conflict541N → S in AAN76985. Ref.2
Sequence conflict691G → S in AAN76985. Ref.2
Sequence conflict781K → E in AAN76985. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8HYQ3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 021CAA371143D12A

FASTA9210,120
        10         20         30         40         50         60 
MQVSTAALAV LLCTVALCNR ISATFAADTP TSCCFSYISR QIPQNFIADY FETNSQCSKP 

        70         80         90 
GVIFLTKRGR QVCADPSKEW VQKYVSDLEL SA 

« Hide

References

[1]"Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
AIDS Res. Hum. Retroviruses 18:627-639(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-85.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF449266 mRNA. Translation: AAN76070.1.
AF457195 mRNA. Translation: AAN76985.1.
RefSeqNP_001029372.1. NM_001034200.1.
UniGeneMmu.3703.

3D structure databases

ProteinModelPortalQ8HYQ3.
SMRQ8HYQ3. Positions 24-92.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000001343; ENSMMUP00000001262; ENSMMUG00000030216.
GeneID619514.
KEGGmcc:619514.

Organism-specific databases

CTD6348.

Phylogenomic databases

eggNOGNOG304839.
GeneTreeENSGT00730000110278.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ8HYQ3.
KOK05408.
OMANTPTACC.
OrthoDBEOG7CVQ1F.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19980056.

Entry information

Entry nameCCL3_MACMU
AccessionPrimary (citable) accession number: Q8HYQ3
Secondary accession number(s): Q8HYN4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families