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Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei40 – 401Involved in GAG bindingBy similarity
Sitei68 – 681Involved in GAG bindingBy similarity
Sitei70 – 701Involved in GAG bindingBy similarity

GO - Molecular functioni

  1. calcium-dependent protein kinase C activity Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. chemokine activity Source: UniProtKB
  4. kinase activity Source: UniProtKB
  5. phospholipase activator activity Source: UniProtKB
  6. protein kinase activity Source: UniProtKB

GO - Biological processi

  1. astrocyte cell migration Source: UniProtKB
  2. behavior Source: UniProtKB
  3. calcium ion transport Source: UniProtKB
  4. calcium-mediated signaling Source: UniProtKB
  5. cell activation Source: UniProtKB
  6. cell-cell signaling Source: UniProtKB
  7. cellular calcium ion homeostasis Source: UniProtKB
  8. cellular response to organic cyclic compound Source: UniProtKB
  9. chemotaxis Source: UniProtKB
  10. cytoskeleton organization Source: UniProtKB
  11. eosinophil chemotaxis Source: UniProtKB
  12. eosinophil degranulation Source: UniProtKB
  13. exocytosis Source: UniProtKB
  14. granulocyte chemotaxis Source: UniProtKB
  15. inflammatory response Source: UniProtKB
  16. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  17. lymphocyte chemotaxis Source: UniProtKB
  18. macrophage chemotaxis Source: UniProtKB
  19. MAPK cascade Source: UniProtKB
  20. monocyte chemotaxis Source: UniProtKB
  21. negative regulation by host of viral transcription Source: UniProtKB
  22. negative regulation of gene expression Source: UniProtKB
  23. negative regulation of osteoclast differentiation Source: UniProtKB
  24. neutrophil chemotaxis Source: UniProtKB
  25. osteoblast differentiation Source: UniProtKB
  26. positive chemotaxis Source: GOC
  27. positive regulation of calcium ion transport Source: UniProtKB
  28. positive regulation of calcium-mediated signaling Source: UniProtKB
  29. positive regulation of catalytic activity Source: GOC
  30. positive regulation of cell migration Source: UniProtKB
  31. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  32. positive regulation of gene expression Source: UniProtKB
  33. positive regulation of inflammatory response Source: UniProtKB
  34. positive regulation of interleukin-1 beta secretion Source: UniProtKB
  35. positive regulation of natural killer cell chemotaxis Source: UniProtKB
  36. positive regulation of neuron apoptotic process Source: UniProtKB
  37. positive regulation of tumor necrosis factor production Source: UniProtKB
  38. protein kinase B signaling Source: UniProtKB
  39. protein phosphorylation Source: UniProtKB
  40. regulation of cell shape Source: UniProtKB
  41. regulation of sensory perception of pain Source: UniProtKB
  42. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
  43. response to cholesterol Source: UniProtKB
  44. response to toxic substance Source: UniProtKB
  45. signaling Source: UniProtKB
  46. T cell chemotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
Small-inducible cytokine A3
Gene namesi
Name:CCL3
Synonyms:MIP1A
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Chromosome 16

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 9266C-C motif chemokine 3PRO_0000042848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Self-associates.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8HYQ3.
SMRiQ8HYQ3. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG304839.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ3.
KOiK05408.
OMAiNTPTACC.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTVALCNR ISATFAADTP TSCCFSYISR QIPQNFIADY
60 70 80 90
FETNSQCSKP GVIFLTKRGR QVCADPSKEW VQKYVSDLEL SA
Length:92
Mass (Da):10,120
Last modified:March 1, 2003 - v1
Checksum:i021CAA371143D12A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321S → A in AAN76985 (PubMed:12079558).Curated
Sequence conflicti38 – 381I → T in AAN76985 (PubMed:12079558).Curated
Sequence conflicti54 – 541N → S in AAN76985 (PubMed:12079558).Curated
Sequence conflicti69 – 691G → S in AAN76985 (PubMed:12079558).Curated
Sequence conflicti78 – 781K → E in AAN76985 (PubMed:12079558).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449266 mRNA. Translation: AAN76070.1.
AF457195 mRNA. Translation: AAN76985.1.
RefSeqiNP_001029372.1. NM_001034200.1.
UniGeneiMmu.3703.

Genome annotation databases

EnsembliENSMMUT00000001343; ENSMMUP00000001262; ENSMMUG00000030216.
GeneIDi619514.
KEGGimcc:619514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449266 mRNA. Translation: AAN76070.1.
AF457195 mRNA. Translation: AAN76985.1.
RefSeqiNP_001029372.1. NM_001034200.1.
UniGeneiMmu.3703.

3D structure databases

ProteinModelPortaliQ8HYQ3.
SMRiQ8HYQ3. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000001343; ENSMMUP00000001262; ENSMMUG00000030216.
GeneIDi619514.
KEGGimcc:619514.

Organism-specific databases

CTDi6348.

Phylogenomic databases

eggNOGiNOG304839.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ3.
KOiK05408.
OMAiNTPTACC.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Miscellaneous databases

NextBioi19980056.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
    Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
    Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
    Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
    AIDS Res. Hum. Retroviruses 18:627-639(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-85.

Entry informationi

Entry nameiCCL3_MACMU
AccessioniPrimary (citable) accession number: Q8HYQ3
Secondary accession number(s): Q8HYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.