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Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Small-inducible cytokine A4
Gene namesi
Name:CCL4
Synonyms:MIP1B, SCYA4
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000326237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Detected in peripheral blood mononuclear cells and lymph nodes.1 Publication

Inductioni

Up-regulated in SIV or SHIV infected monkeys with decreased CD4+ T-cell count.1 Publication

Interactioni

Subunit structurei

Homodimer. Interacts with CCR5 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8HYQ2.
SMRiQ8HYQ2. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ2.
KOiK12964.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLCVTVLSL LVLAAAFCSP ALSAPMGSDP PTSCCFSYTA RKLPRNFVVD
60 70 80 90
YYETSSLCSQ PAVVFQTKRG KQVCADPSET WVQEYVNDLE LN
Length:92
Mass (Da):10,103
Last modified:March 1, 2003 - v1
Checksum:i80B2C2071565F809
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401A → V in AAN76986 (PubMed:12126650).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449267 mRNA. Translation: AAN76071.1.
AF457196 mRNA. Translation: AAN76986.1.
RefSeqiNP_001028045.1. NM_001032873.1.
UniGeneiMmu.10321.

Genome annotation databases

GeneIDi574217.
KEGGimcc:574217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449267 mRNA. Translation: AAN76071.1.
AF457196 mRNA. Translation: AAN76986.1.
RefSeqiNP_001028045.1. NM_001032873.1.
UniGeneiMmu.10321.

3D structure databases

ProteinModelPortaliQ8HYQ2.
SMRiQ8HYQ2. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574217.
KEGGimcc:574217.

Organism-specific databases

CTDi388372.

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ2.
KOiK12964.

Miscellaneous databases

NextBioi19977593.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
    Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
    Cytokine 18:140-148(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
  2. "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
    Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
    AIDS Res. Hum. Retroviruses 18:627-639(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-83, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCCL4_MACMU
AccessioniPrimary (citable) accession number: Q8HYQ2
Secondary accession number(s): Q8HYN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.