Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Small-inducible cytokine A4
Gene namesi
Name:CCL4
Synonyms:MIP1B, SCYA4
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000326237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Detected in peripheral blood mononuclear cells and lymph nodes.1 Publication

Inductioni

Up-regulated in SIV or SHIV infected monkeys with decreased CD4+ T-cell count.1 Publication

Interactioni

Subunit structurei

Homodimer. Interacts with CCR5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000032483.

Structurei

3D structure databases

ProteinModelPortaliQ8HYQ2.
SMRiQ8HYQ2. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ2.
KOiK12964.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLCVTVLSL LVLAAAFCSP ALSAPMGSDP PTSCCFSYTA RKLPRNFVVD
60 70 80 90
YYETSSLCSQ PAVVFQTKRG KQVCADPSET WVQEYVNDLE LN
Length:92
Mass (Da):10,103
Last modified:March 1, 2003 - v1
Checksum:i80B2C2071565F809
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401A → V in AAN76986 (PubMed:12126650).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449267 mRNA. Translation: AAN76071.1.
AF457196 mRNA. Translation: AAN76986.1.
RefSeqiNP_001028045.1. NM_001032873.1.
UniGeneiMmu.10321.

Genome annotation databases

GeneIDi574217.
KEGGimcc:574217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449267 mRNA. Translation: AAN76071.1.
AF457196 mRNA. Translation: AAN76986.1.
RefSeqiNP_001028045.1. NM_001032873.1.
UniGeneiMmu.10321.

3D structure databases

ProteinModelPortaliQ8HYQ2.
SMRiQ8HYQ2. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000032483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574217.
KEGGimcc:574217.

Organism-specific databases

CTDi388372.

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYQ2.
KOiK12964.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL4_MACMU
AccessioniPrimary (citable) accession number: Q8HYQ2
Secondary accession number(s): Q8HYN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.