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Q8HYQ2

- CCL4_MACMU

UniProt

Q8HYQ2 - CCL4_MACMU

Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Monokine with inflammatory and chemokinetic properties.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 4
    Alternative name(s):
    Macrophage inflammatory protein 1-beta
    Short name:
    MIP-1-beta
    Small-inducible cytokine A4
    Gene namesi
    Name:CCL4
    Synonyms:MIP1B, SCYA4
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9269C-C motif chemokine 4PRO_0000326237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Detected in peripheral blood mononuclear cells and lymph nodes.1 Publication

    Inductioni

    Up-regulated in SIV or SHIV infected monkeys with decreased CD4+ T-cell count.1 Publication

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CCR5 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HYQ2.
    SMRiQ8HYQ2. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG124416.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8HYQ2.
    KOiK12964.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HYQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCVTVLSL LVLAAAFCSP ALSAPMGSDP PTSCCFSYTA RKLPRNFVVD   50
    YYETSSLCSQ PAVVFQTKRG KQVCADPSET WVQEYVNDLE LN 92
    Length:92
    Mass (Da):10,103
    Last modified:March 1, 2003 - v1
    Checksum:i80B2C2071565F809
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401A → V in AAN76986. (PubMed:12126650)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449267 mRNA. Translation: AAN76071.1.
    AF457196 mRNA. Translation: AAN76986.1.
    RefSeqiNP_001028045.1. NM_001032873.1.
    UniGeneiMmu.10321.

    Genome annotation databases

    GeneIDi574217.
    KEGGimcc:574217.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449267 mRNA. Translation: AAN76071.1 .
    AF457196 mRNA. Translation: AAN76986.1 .
    RefSeqi NP_001028045.1. NM_001032873.1.
    UniGenei Mmu.10321.

    3D structure databases

    ProteinModelPortali Q8HYQ2.
    SMRi Q8HYQ2. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 574217.
    KEGGi mcc:574217.

    Organism-specific databases

    CTDi 388372.

    Phylogenomic databases

    eggNOGi NOG124416.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8HYQ2.
    KOi K12964.

    Miscellaneous databases

    NextBioi 19977593.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
      Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
      Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
    2. "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
      Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
      AIDS Res. Hum. Retroviruses 18:627-639(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-83, INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCCL4_MACMU
    AccessioniPrimary (citable) accession number: Q8HYQ2
    Secondary accession number(s): Q8HYN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3