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Q8HYQ2 (CCL4_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name=MIP-1-beta
Small-inducible cytokine A4
Gene names
Name:CCL4
Synonyms:MIP1B, SCYA4
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Monokine with inflammatory and chemokinetic properties By similarity.

Subunit structure

Homodimer. Interacts with CCR5 By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Detected in peripheral blood mononuclear cells and lymph nodes. Ref.2

Induction

Up-regulated in SIV or SHIV infected monkeys with decreased CD4+ T-cell count. Ref.2

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9269C-C motif chemokine 4
PRO_0000326237

Amino acid modifications

Disulfide bond34 ↔ 58 By similarity
Disulfide bond35 ↔ 74 By similarity

Experimental info

Sequence conflict401A → V in AAN76986. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8HYQ2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 80B2C2071565F809

FASTA9210,103
        10         20         30         40         50         60 
MKLCVTVLSL LVLAAAFCSP ALSAPMGSDP PTSCCFSYTA RKLPRNFVVD YYETSSLCSQ 

        70         80         90 
PAVVFQTKRG KQVCADPSET WVQEYVNDLE LN 

« Hide

References

[1]"Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
[2]"Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
AIDS Res. Hum. Retroviruses 18:627-639(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-83, INDUCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF449267 mRNA. Translation: AAN76071.1.
AF457196 mRNA. Translation: AAN76986.1.
RefSeqNP_001028045.1. NM_001032873.1.
UniGeneMmu.10321.

3D structure databases

ProteinModelPortalQ8HYQ2.
SMRQ8HYQ2. Positions 24-92.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID574217.
KEGGmcc:574217.

Organism-specific databases

CTD388372.

Phylogenomic databases

eggNOGNOG124416.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ8HYQ2.
KOK12964.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19977593.

Entry information

Entry nameCCL4_MACMU
AccessionPrimary (citable) accession number: Q8HYQ2
Secondary accession number(s): Q8HYN3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families