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Q8HYQ1 (CCL5_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene names
Name:CCL5
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9168C-C motif chemokine 5
PRO_0000005178

Amino acid modifications

Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8HYQ1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: BCBD69ED0573803B

FASTA9110,019
        10         20         30         40         50         60 
MKVSAARLAV ILVATALCAP ASASPHASDT TPCCFAYIAR PLPRAHIKEY FYTSGKCSNP 

        70         80         90 
AVVFVTRKNR QVCANPEKKW VREYINSLEM S 

« Hide

References

[1]"Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
AIDS Res. Hum. Retroviruses 18:627-639(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-81.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF449268 mRNA. Translation: AAN76072.1.
AF457194 mRNA. Translation: AAN76984.1.
RefSeqNP_001028022.1. NM_001032850.1.
UniGeneMmu.3698.

3D structure databases

ProteinModelPortalQ8HYQ1.
SMRQ8HYQ1. Positions 24-91.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID574178.
KEGGmcc:574178.

Organism-specific databases

CTD6352.

Phylogenomic databases

eggNOGNOG38896.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ8HYQ1.
KOK12499.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19960499.

Entry information

Entry nameCCL5_MACMU
AccessionPrimary (citable) accession number: Q8HYQ1
Secondary accession number(s): Q8HYN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families