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Q8HYQ1

- CCL5_MACMU

UniProt

Q8HYQ1 - CCL5_MACMU

Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5 By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 5
    Alternative name(s):
    Small-inducible cytokine A5
    T-cell-specific protein RANTES
    Gene namesi
    Name:CCL5
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168C-C motif chemokine 5PRO_0000005178Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HYQ1.
    SMRiQ8HYQ1. Positions 24-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38896.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8HYQ1.
    KOiK12499.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HYQ1-1 [UniParc]FASTAAdd to Basket

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    MKVSAARLAV ILVATALCAP ASASPHASDT TPCCFAYIAR PLPRAHIKEY   50
    FYTSGKCSNP AVVFVTRKNR QVCANPEKKW VREYINSLEM S 91
    Length:91
    Mass (Da):10,019
    Last modified:March 1, 2003 - v1
    Checksum:iBCBD69ED0573803B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449268 mRNA. Translation: AAN76072.1.
    AF457194 mRNA. Translation: AAN76984.1.
    RefSeqiNP_001028022.1. NM_001032850.1.
    UniGeneiMmu.3698.

    Genome annotation databases

    GeneIDi574178.
    KEGGimcc:574178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449268 mRNA. Translation: AAN76072.1 .
    AF457194 mRNA. Translation: AAN76984.1 .
    RefSeqi NP_001028022.1. NM_001032850.1.
    UniGenei Mmu.3698.

    3D structure databases

    ProteinModelPortali Q8HYQ1.
    SMRi Q8HYQ1. Positions 24-91.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 574178.
    KEGGi mcc:574178.

    Organism-specific databases

    CTDi 6352.

    Phylogenomic databases

    eggNOGi NOG38896.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8HYQ1.
    KOi K12499.

    Miscellaneous databases

    NextBioi 19960499.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
      Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
      Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection."
      Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L., Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.
      AIDS Res. Hum. Retroviruses 18:627-639(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-81.

    Entry informationi

    Entry nameiCCL5_MACMU
    AccessioniPrimary (citable) accession number: Q8HYQ1
    Secondary accession number(s): Q8HYN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3