Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8HYP9

- CCL17_MACMU

UniProt

Q8HYP9 - CCL17_MACMU

Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 17
    Alternative name(s):
    CC chemokine TARC
    Small-inducible cytokine A17
    Thymus and activation-regulated chemokine
    Gene namesi
    Name:CCL17
    Synonyms:TARC
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9471C-C motif chemokine 17PRO_0000244871Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000023940.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HYP9.
    SMRiQ8HYP9. Positions 26-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45053.
    HOGENOMiHOG000036685.
    HOVERGENiHBG098492.
    InParanoidiQ8HYP9.
    KOiK05514.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HYP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLKMLALV ILLLGASLQH IHAARGTNVG RECCLKYFKG AIPLRKLKTW   50
    YQTSEDCSRD AIVFVTVQNK AICSDPNDKK VKKALKYLQS LERS 94
    Length:94
    Mass (Da):10,549
    Last modified:March 1, 2003 - v1
    Checksum:iE07D40ED36199BFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449271 mRNA. Translation: AAN76075.1.
    RefSeqiNP_001028024.1. NM_001032852.1.
    UniGeneiMmu.3705.

    Genome annotation databases

    GeneIDi574180.
    KEGGimcc:574180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449271 mRNA. Translation: AAN76075.1 .
    RefSeqi NP_001028024.1. NM_001032852.1.
    UniGenei Mmu.3705.

    3D structure databases

    ProteinModelPortali Q8HYP9.
    SMRi Q8HYP9. Positions 26-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000023940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 574180.
    KEGGi mcc:574180.

    Organism-specific databases

    CTDi 6361.

    Phylogenomic databases

    eggNOGi NOG45053.
    HOGENOMi HOG000036685.
    HOVERGENi HBG098492.
    InParanoidi Q8HYP9.
    KOi K05514.

    Miscellaneous databases

    NextBioi 19962660.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
      Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
      Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL17_MACMU
    AccessioniPrimary (citable) accession number: Q8HYP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3