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Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity).By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. negative regulation of myoblast differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:TARC
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9471C-C motif chemokine 17PRO_0000244871Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ8HYP9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000023940.

Structurei

3D structure databases

ProteinModelPortaliQ8HYP9.
SMRiQ8HYP9. Positions 26-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45053.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ8HYP9.
KOiK05514.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLKMLALV ILLLGASLQH IHAARGTNVG RECCLKYFKG AIPLRKLKTW
60 70 80 90
YQTSEDCSRD AIVFVTVQNK AICSDPNDKK VKKALKYLQS LERS
Length:94
Mass (Da):10,549
Last modified:March 1, 2003 - v1
Checksum:iE07D40ED36199BFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449271 mRNA. Translation: AAN76075.1.
RefSeqiNP_001028024.1. NM_001032852.1.
UniGeneiMmu.3705.

Genome annotation databases

GeneIDi574180.
KEGGimcc:574180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449271 mRNA. Translation: AAN76075.1.
RefSeqiNP_001028024.1. NM_001032852.1.
UniGeneiMmu.3705.

3D structure databases

ProteinModelPortaliQ8HYP9.
SMRiQ8HYP9. Positions 26-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000023940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574180.
KEGGimcc:574180.

Organism-specific databases

CTDi6361.

Phylogenomic databases

eggNOGiNOG45053.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ8HYP9.
KOiK05514.

Miscellaneous databases

NextBioi19962660.

Gene expression databases

ExpressionAtlasiQ8HYP9. baseline.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
    Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
    Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL17_MACMU
AccessioniPrimary (citable) accession number: Q8HYP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.