ID   CCL18_MACMU             Reviewed;          88 AA.
AC   Q8HYP8;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=C-C motif chemokine 18;
DE   AltName: Full=Small-inducible cytokine A18;
DE   Flags: Precursor;
GN   Name=CCL18;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12126650; DOI=10.1006/cyto.2002.0875;
RA   Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.;
RT   "Molecular cloning and sequencing of 25 different rhesus macaque chemokine
RT   cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families
RT   of chemokines.";
RL   Cytokine 18:140-148(2002).
CC   -!- FUNCTION: Chemotactic factor that attracts lymphocytes but not
CC       monocytes or granulocytes. May be involved in B-cell migration into B-
CC       cell follicles in lymph nodes. Attracts naive T-lymphocytes toward
CC       dendritic cells and activated macrophages in lymph nodes, has
CC       chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
CC       may play a role in both humoral and cell-mediated immunity responses
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: The Cys-29/Cys-53 disulfide bond is required for activity.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF449272; AAN76076.1; -; mRNA.
DR   RefSeq; NP_001028025.1; NM_001032853.1.
DR   AlphaFoldDB; Q8HYP8; -.
DR   SMR; Q8HYP8; -.
DR   STRING; 9544.ENSMMUP00000060950; -.
DR   PaxDb; 9544-ENSMMUP00000001257; -.
DR   GeneID; 574181; -.
DR   KEGG; mcc:574181; -.
DR   CTD; 6362; -.
DR   eggNOG; ENOG502S8M4; Eukaryota.
DR   InParanoid; Q8HYP8; -.
DR   OrthoDB; 4265193at2759; -.
DR   Proteomes; UP000006718; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF94; C-C MOTIF CHEMOKINE 18; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00436; INTERLEUKIN8.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..88
FT                   /note="C-C motif chemokine 18"
FT                   /id="PRO_0000005213"
FT   DISULFID        29..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..69
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   88 AA;  9797 MW;  19267D02F750D88F CRC64;
     MKGLAAALLV LCTVALCSCA QVGTKKEFCC LVYTSRQIPQ KFIVDYSETS PQCTKPGVIL
     LSKKRRQICA DPNKKWVQKY ISDLKLNA
//