SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8HYP8

- CCL18_MACMU

UniProt

Q8HYP8 - CCL18_MACMU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

C-C motif chemokine 18

Gene
CCL18
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses By similarity.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 18
Alternative name(s):
Small-inducible cytokine A18
Gene namesi
Name:CCL18
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 8869C-C motif chemokine 18PRO_0000005213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 53 By similarity
Disulfide bondi30 ↔ 69 By similarity

Post-translational modificationi

The Cys-29/Cys-53 disulfide bond is required for activity.

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001257.

Structurei

3D structure databases

ProteinModelPortaliQ8HYP8.
SMRiQ8HYP8. Positions 29-88.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG67988.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP8.
KOiK05514.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYP8-1 [UniParc]FASTAAdd to Basket

« Hide

MKGLAAALLV LCTVALCSCA QVGTKKEFCC LVYTSRQIPQ KFIVDYSETS   50
PQCTKPGVIL LSKKRRQICA DPNKKWVQKY ISDLKLNA 88
Length:88
Mass (Da):9,797
Last modified:March 1, 2003 - v1
Checksum:i19267D02F750D88F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF449272 mRNA. Translation: AAN76076.1.
RefSeqiNP_001028025.1. NM_001032853.1.
UniGeneiMmu.3706.

Genome annotation databases

GeneIDi574181.
KEGGimcc:574181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF449272 mRNA. Translation: AAN76076.1 .
RefSeqi NP_001028025.1. NM_001032853.1.
UniGenei Mmu.3706.

3D structure databases

ProteinModelPortali Q8HYP8.
SMRi Q8HYP8. Positions 29-88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000001257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 574181.
KEGGi mcc:574181.

Organism-specific databases

CTDi 6362.

Phylogenomic databases

eggNOGi NOG67988.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q8HYP8.
KOi K05514.

Miscellaneous databases

NextBioi 19973184.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
    Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
    Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL18_MACMU
AccessioniPrimary (citable) accession number: Q8HYP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi