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Protein

C-C motif chemokine 18

Gene

CCL18

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 18
Alternative name(s):
Small-inducible cytokine A18
Gene namesi
Name:CCL18
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 8869C-C motif chemokine 18PRO_0000005213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 53By similarity
Disulfide bondi30 ↔ 69By similarity

Post-translational modificationi

The Cys-29/Cys-53 disulfide bond is required for activity.

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001257.

Structurei

3D structure databases

ProteinModelPortaliQ8HYP8.
SMRiQ8HYP8. Positions 29-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG67988.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP8.
KOiK05514.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLAAALLV LCTVALCSCA QVGTKKEFCC LVYTSRQIPQ KFIVDYSETS
60 70 80
PQCTKPGVIL LSKKRRQICA DPNKKWVQKY ISDLKLNA
Length:88
Mass (Da):9,797
Last modified:March 1, 2003 - v1
Checksum:i19267D02F750D88F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449272 mRNA. Translation: AAN76076.1.
RefSeqiNP_001028025.1. NM_001032853.1.
UniGeneiMmu.3706.

Genome annotation databases

GeneIDi574181.
KEGGimcc:574181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449272 mRNA. Translation: AAN76076.1.
RefSeqiNP_001028025.1. NM_001032853.1.
UniGeneiMmu.3706.

3D structure databases

ProteinModelPortaliQ8HYP8.
SMRiQ8HYP8. Positions 29-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574181.
KEGGimcc:574181.

Organism-specific databases

CTDi6362.

Phylogenomic databases

eggNOGiNOG67988.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP8.
KOiK05514.

Miscellaneous databases

NextBioi19973184.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
    Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
    Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL18_MACMU
AccessioniPrimary (citable) accession number: Q8HYP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.