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Q8HYP8 (CCL18_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 18
Alternative name(s):
Small-inducible cytokine A18
Gene names
Name:CCL18
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length88 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses By similarity.

Subcellular location

Secreted By similarity.

Post-translational modification

The Cys-29/Cys-53 disulfide bond is required for activity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 8869C-C motif chemokine 18
PRO_0000005213

Amino acid modifications

Disulfide bond29 ↔ 53 By similarity
Disulfide bond30 ↔ 69 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8HYP8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 19267D02F750D88F

FASTA889,797
        10         20         30         40         50         60 
MKGLAAALLV LCTVALCSCA QVGTKKEFCC LVYTSRQIPQ KFIVDYSETS PQCTKPGVIL 

        70         80 
LSKKRRQICA DPNKKWVQKY ISDLKLNA 

« Hide

References

[1]"Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF449272 mRNA. Translation: AAN76076.1.
RefSeqNP_001028025.1. NM_001032853.1.
UniGeneMmu.3706.

3D structure databases

ProteinModelPortalQ8HYP8.
SMRQ8HYP8. Positions 29-88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000001257.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID574181.
KEGGmcc:574181.

Organism-specific databases

CTD6362.

Phylogenomic databases

eggNOGNOG67988.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ8HYP8.
KOK05514.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19973184.

Entry information

Entry nameCCL18_MACMU
AccessionPrimary (citable) accession number: Q8HYP8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families