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Q8HYP8

- CCL18_MACMU

UniProt

Q8HYP8 - CCL18_MACMU

Protein

C-C motif chemokine 18

Gene

CCL18

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 18
    Alternative name(s):
    Small-inducible cytokine A18
    Gene namesi
    Name:CCL18
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 8869C-C motif chemokine 18PRO_0000005213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 53By similarity
    Disulfide bondi30 ↔ 69By similarity

    Post-translational modificationi

    The Cys-29/Cys-53 disulfide bond is required for activity.

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000001257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HYP8.
    SMRiQ8HYP8. Positions 29-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG67988.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8HYP8.
    KOiK05514.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HYP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGLAAALLV LCTVALCSCA QVGTKKEFCC LVYTSRQIPQ KFIVDYSETS   50
    PQCTKPGVIL LSKKRRQICA DPNKKWVQKY ISDLKLNA 88
    Length:88
    Mass (Da):9,797
    Last modified:March 1, 2003 - v1
    Checksum:i19267D02F750D88F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449272 mRNA. Translation: AAN76076.1.
    RefSeqiNP_001028025.1. NM_001032853.1.
    UniGeneiMmu.3706.

    Genome annotation databases

    GeneIDi574181.
    KEGGimcc:574181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449272 mRNA. Translation: AAN76076.1 .
    RefSeqi NP_001028025.1. NM_001032853.1.
    UniGenei Mmu.3706.

    3D structure databases

    ProteinModelPortali Q8HYP8.
    SMRi Q8HYP8. Positions 29-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000001257.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 574181.
    KEGGi mcc:574181.

    Organism-specific databases

    CTDi 6362.

    Phylogenomic databases

    eggNOGi NOG67988.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8HYP8.
    KOi K05514.

    Miscellaneous databases

    NextBioi 19973184.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
      Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
      Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL18_MACMU
    AccessioniPrimary (citable) accession number: Q8HYP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3