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Protein

C-C motif chemokine

Gene
N/A
Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626UniRule annotationAdd
BLAST
Chaini27 – 9670C-C motif chemokineUniRule annotationPRO_5005144479Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000017423.

Structurei

3D structure databases

ProteinModelPortaliQ8HYP6.
SMRiQ8HYP6. Positions 27-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 8961SCYInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J2BK. Eukaryota.
ENOG410ZGME. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
KOiK14625.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HYP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCCTKSLLLA ALMSVLLLYL CSESEAASNF DCCLRYTDRI LHPKFIVGFT
60 70 80 90
QQLANETCDI NAVVFHTKKG LSVCANPKQT WVKLIVRRLS KKINKM
Length:96
Mass (Da):10,841
Last modified:March 1, 2003 - v1
Checksum:i578974EE79BFC32B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449274 mRNA. Translation: AAN76078.1.
RefSeqiNP_001028026.1. NM_001032854.1.
UniGeneiMmu.3708.

Genome annotation databases

GeneIDi574182.
KEGGimcc:574182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449274 mRNA. Translation: AAN76078.1.
RefSeqiNP_001028026.1. NM_001032854.1.
UniGeneiMmu.3708.

3D structure databases

ProteinModelPortaliQ8HYP6.
SMRiQ8HYP6. Positions 27-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000017423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574182.
KEGGimcc:574182.

Organism-specific databases

CTDi6364.

Phylogenomic databases

eggNOGiENOG410J2BK. Eukaryota.
ENOG410ZGME. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
KOiK14625.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
    Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
    Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8HYP6_MACMU
AccessioniPrimary (citable) accession number: Q8HYP6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.