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Q8HYP5 (CCL21_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 21
Alternative name(s):
Small-inducible cytokine A21
Gene names
Name:CCL21
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 By similarity.

Subunit structure

Monomer. Binds to CCR7 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of Rho GTPase activity

Inferred from electronic annotation. Source: Ensembl

dendritic cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

establishment of T cell polarity

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

mesangial cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

negative regulation of leukocyte apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of JNK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin filament polymerization

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell adhesion mediated by integrin

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of filopodium assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of myeloid dendritic cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of pseudopodium assembly

Inferred from electronic annotation. Source: Ensembl

release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

response to prostaglandin E

Inferred from electronic annotation. Source: Ensembl

ruffle organization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionchemokine receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 131108C-C motif chemokine 21
PRO_0000005221

Amino acid modifications

Disulfide bond31 ↔ 57 By similarity
Disulfide bond32 ↔ 75 By similarity
Disulfide bond103 ↔ 119 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8HYP5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B8FFF8A7E2FECC1D

FASTA13114,368
        10         20         30         40         50         60 
MAQSLALSLL ILVLAFGIPG TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK QEPSLGCSIP 

        70         80         90        100        110        120 
AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPTPRKPV QGCRKDRGVP KNGKKGKGCK 

       130 
RTEQSQTPKG P 

« Hide

References

[1]"Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF449275 mRNA. Translation: AAN76079.1.
RefSeqNP_001028027.1. NM_001032855.1.
UniGeneMmu.3682.

3D structure databases

ProteinModelPortalQ8HYP5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000021721.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000023217; ENSMMUP00000021721; ENSMMUG00000016529.
GeneID574183.
KEGGmcc:574183.

Organism-specific databases

CTD6366.

Phylogenomic databases

eggNOGNOG46090.
GeneTreeENSGT00730000111297.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ8HYP5.
KOK16062.
OMACCLKYSL.
OrthoDBEOG7GXPDG.
TreeFamTF338224.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

NextBio19965536.

Entry information

Entry nameCCL21_MACMU
AccessionPrimary (citable) accession number: Q8HYP5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families