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Q8HYP5

- CCL21_MACMU

UniProt

Q8HYP5 - CCL21_MACMU

Protein

C-C motif chemokine 21

Gene

CCL21

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 By similarity.By similarity

    GO - Molecular functioni

    1. chemokine receptor binding Source: UniProtKB

    GO - Biological processi

    1. activation of Rho GTPase activity Source: Ensembl
    2. dendritic cell chemotaxis Source: Ensembl
    3. establishment of T cell polarity Source: Ensembl
    4. immune response Source: InterPro
    5. inflammatory response Source: UniProtKB-KW
    6. mesangial cell-matrix adhesion Source: Ensembl
    7. negative regulation of leukocyte apoptotic process Source: Ensembl
    8. positive regulation of actin filament polymerization Source: Ensembl
    9. positive regulation of cell adhesion mediated by integrin Source: Ensembl
    10. positive regulation of cell-matrix adhesion Source: Ensembl
    11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    12. positive regulation of filopodium assembly Source: Ensembl
    13. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    14. positive regulation of JNK cascade Source: Ensembl
    15. positive regulation of myeloid dendritic cell chemotaxis Source: Ensembl
    16. positive regulation of neutrophil chemotaxis Source: Ensembl
    17. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
    18. positive regulation of protein kinase activity Source: Ensembl
    19. positive regulation of protein kinase B signaling Source: Ensembl
    20. positive regulation of pseudopodium assembly Source: Ensembl
    21. release of sequestered calcium ion into cytosol Source: Ensembl
    22. response to prostaglandin E Source: Ensembl
    23. ruffle organization Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 21
    Alternative name(s):
    Small-inducible cytokine A21
    Gene namesi
    Name:CCL21
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 15

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 131108C-C motif chemokine 21PRO_0000005221Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 57By similarity
    Disulfide bondi32 ↔ 75By similarity
    Disulfide bondi103 ↔ 119Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer. Binds to CCR7 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000021721.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HYP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46090.
    GeneTreeiENSGT00730000111297.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8HYP5.
    KOiK16062.
    OMAiCCLKYSL.
    OrthoDBiEOG7GXPDG.
    TreeFamiTF338224.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HYP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQSLALSLL ILVLAFGIPG TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK    50
    QEPSLGCSIP AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPTPRKPV 100
    QGCRKDRGVP KNGKKGKGCK RTEQSQTPKG P 131
    Length:131
    Mass (Da):14,368
    Last modified:March 1, 2003 - v1
    Checksum:iB8FFF8A7E2FECC1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449275 mRNA. Translation: AAN76079.1.
    RefSeqiNP_001028027.1. NM_001032855.1.
    UniGeneiMmu.3682.

    Genome annotation databases

    EnsembliENSMMUT00000023217; ENSMMUP00000021721; ENSMMUG00000016529.
    GeneIDi574183.
    KEGGimcc:574183.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449275 mRNA. Translation: AAN76079.1 .
    RefSeqi NP_001028027.1. NM_001032855.1.
    UniGenei Mmu.3682.

    3D structure databases

    ProteinModelPortali Q8HYP5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000021721.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000023217 ; ENSMMUP00000021721 ; ENSMMUG00000016529 .
    GeneIDi 574183.
    KEGGi mcc:574183.

    Organism-specific databases

    CTDi 6366.

    Phylogenomic databases

    eggNOGi NOG46090.
    GeneTreei ENSGT00730000111297.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8HYP5.
    KOi K16062.
    OMAi CCLKYSL.
    OrthoDBi EOG7GXPDG.
    TreeFami TF338224.

    Miscellaneous databases

    NextBioi 19965536.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
      Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
      Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL21_MACMU
    AccessioniPrimary (citable) accession number: Q8HYP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3