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Protein

C-C motif chemokine 21

Gene

CCL21

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21
Alternative name(s):
Small-inducible cytokine A21
Gene namesi
Name:CCL21
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 131108C-C motif chemokine 21PRO_0000005221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 57By similarity
Disulfide bondi32 ↔ 75By similarity
Disulfide bondi103 ↔ 119Sequence analysis

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSMMUG00000016529.

Interactioni

Subunit structurei

Monomer. Binds to CCR7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000021721.

Structurei

3D structure databases

ProteinModelPortaliQ8HYP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3QM. Eukaryota.
ENOG410Z7F2. LUCA.
GeneTreeiENSGT00730000111297.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP5.
KOiK16062.
OMAiCKRTEQP.
OrthoDBiEOG091G14NY.
TreeFamiTF338224.

Family and domain databases

InterProiIPR030593. CCL21.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF72. PTHR12015:SF72. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSLALSLL ILVLAFGIPG TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK
60 70 80 90 100
QEPSLGCSIP AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPTPRKPV
110 120 130
QGCRKDRGVP KNGKKGKGCK RTEQSQTPKG P
Length:131
Mass (Da):14,368
Last modified:March 1, 2003 - v1
Checksum:iB8FFF8A7E2FECC1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449275 mRNA. Translation: AAN76079.1.
RefSeqiNP_001028027.1. NM_001032855.1.
UniGeneiMmu.3682.

Genome annotation databases

EnsembliENSMMUT00000023217; ENSMMUP00000021721; ENSMMUG00000016529.
GeneIDi574183.
KEGGimcc:574183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449275 mRNA. Translation: AAN76079.1.
RefSeqiNP_001028027.1. NM_001032855.1.
UniGeneiMmu.3682.

3D structure databases

ProteinModelPortaliQ8HYP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000021721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000023217; ENSMMUP00000021721; ENSMMUG00000016529.
GeneIDi574183.
KEGGimcc:574183.

Organism-specific databases

CTDi6366.

Phylogenomic databases

eggNOGiENOG410J3QM. Eukaryota.
ENOG410Z7F2. LUCA.
GeneTreeiENSGT00730000111297.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP5.
KOiK16062.
OMAiCKRTEQP.
OrthoDBiEOG091G14NY.
TreeFamiTF338224.

Gene expression databases

BgeeiENSMMUG00000016529.

Family and domain databases

InterProiIPR030593. CCL21.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF72. PTHR12015:SF72. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCL21_MACMU
AccessioniPrimary (citable) accession number: Q8HYP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.