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Protein

C-C motif chemokine 21

Gene

CCL21

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21
Alternative name(s):
Small-inducible cytokine A21
Gene namesi
Name:CCL21
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000522124 – 131C-C motif chemokine 21Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 57By similarity
Disulfide bondi32 ↔ 75By similarity
Disulfide bondi103 ↔ 119Sequence analysis

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSMMUG00000016529

Interactioni

Subunit structurei

Monomer. Binds to CCR7 (By similarity). Interacts with PDPN; relocalizes PDPN to the basolateral membrane (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000021721

Structurei

3D structure databases

ProteinModelPortaliQ8HYP5
SMRiQ8HYP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3QM Eukaryota
ENOG410Z7F2 LUCA
GeneTreeiENSGT00730000111297
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ8HYP5
KOiK16062
OMAiCKRTEQP
OrthoDBiEOG091G14NY
TreeFamiTF338224

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR030593 CCL21
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF72 PTHR12015:SF72, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSLALSLL ILVLAFGIPG TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK
60 70 80 90 100
QEPSLGCSIP AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPTPRKPV
110 120 130
QGCRKDRGVP KNGKKGKGCK RTEQSQTPKG P
Length:131
Mass (Da):14,368
Last modified:March 1, 2003 - v1
Checksum:iB8FFF8A7E2FECC1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449275 mRNA Translation: AAN76079.1
RefSeqiNP_001028027.1, NM_001032855.1
UniGeneiMmu.3682

Genome annotation databases

EnsembliENSMMUT00000062692; ENSMMUP00000048086; ENSMMUG00000038157
GeneIDi574183
KEGGimcc:574183

Similar proteinsi

Entry informationi

Entry nameiCCL21_MACMU
AccessioniPrimary (citable) accession number: Q8HYP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health