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Q8HYP4 (CCL23_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 23
Alternative name(s):
Small-inducible cytokine A23
Gene names
Name:CCL23
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   LigandHeparin-binding
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 12099C-C motif chemokine 23
PRO_0000005230

Amino acid modifications

Disulfide bond54 ↔ 78 By similarity
Disulfide bond55 ↔ 94 By similarity
Disulfide bond65 ↔ 105 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8HYP4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 4FE761D77B67BE01

FASTA12012,932
        10         20         30         40         50         60 
MKVSVAALSC LMLVTALGSQ AQVTNDAETG FMMSKLSLAN SEVLDSFHAI NADCCTSYIP 

        70         80         90        100        110        120 
GSIPCSLLES YLETSSKCPK PGVIFLTKNG RRLCVSPSNK QVLACRIMLK LATRIKTRKN 

« Hide

References

[1]"Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF449276 mRNA. Translation: AAN76080.1.
RefSeqNP_001028118.1. NM_001032946.1.
UniGeneMmu.1186.

3D structure databases

ProteinModelPortalQ8HYP4.
SMRQ8HYP4. Positions 44-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000001256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID574366.
KEGGmcc:574366.

Organism-specific databases

CTD6368.

Phylogenomic databases

eggNOGNOG136395.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ8HYP4.
KOK05511.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19967586.

Entry information

Entry nameCCL23_MACMU
AccessionPrimary (citable) accession number: Q8HYP4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families