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Q8HYP4

- CCL23_MACMU

UniProt

Q8HYP4 - CCL23_MACMU

Protein

C-C motif chemokine 23

Gene

CCL23

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 23
    Alternative name(s):
    Small-inducible cytokine A23
    Gene namesi
    Name:CCL23
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 12099C-C motif chemokine 23PRO_0000005230Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 78By similarity
    Disulfide bondi55 ↔ 94By similarity
    Disulfide bondi65 ↔ 105By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000001256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HYP4.
    SMRiQ8HYP4. Positions 44-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG136395.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8HYP4.
    KOiK05511.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HYP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSVAALSC LMLVTALGSQ AQVTNDAETG FMMSKLSLAN SEVLDSFHAI    50
    NADCCTSYIP GSIPCSLLES YLETSSKCPK PGVIFLTKNG RRLCVSPSNK 100
    QVLACRIMLK LATRIKTRKN 120
    Length:120
    Mass (Da):12,932
    Last modified:March 1, 2003 - v1
    Checksum:i4FE761D77B67BE01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449276 mRNA. Translation: AAN76080.1.
    RefSeqiNP_001028118.1. NM_001032946.1.
    UniGeneiMmu.1186.

    Genome annotation databases

    GeneIDi574366.
    KEGGimcc:574366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF449276 mRNA. Translation: AAN76080.1 .
    RefSeqi NP_001028118.1. NM_001032946.1.
    UniGenei Mmu.1186.

    3D structure databases

    ProteinModelPortali Q8HYP4.
    SMRi Q8HYP4. Positions 44-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000001256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 574366.
    KEGGi mcc:574366.

    Organism-specific databases

    CTDi 6368.

    Phylogenomic databases

    eggNOGi NOG136395.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8HYP4.
    KOi K05511.

    Miscellaneous databases

    NextBioi 19967586.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
      Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
      Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL23_MACMU
    AccessioniPrimary (citable) accession number: Q8HYP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3