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Protein

C-C motif chemokine 23

Gene

CCL23

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 23
Alternative name(s):
Small-inducible cytokine A23
Gene namesi
Name:CCL23
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 12099C-C motif chemokine 23PRO_0000005230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 78By similarity
Disulfide bondi55 ↔ 94By similarity
Disulfide bondi65 ↔ 105By similarity

Keywords - PTMi

Disulfide bond

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001256.

Structurei

3D structure databases

ProteinModelPortaliQ8HYP4.
SMRiQ8HYP4. Positions 44-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP4.
KOiK05511.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSVAALSC LMLVTALGSQ AQVTNDAETG FMMSKLSLAN SEVLDSFHAI
60 70 80 90 100
NADCCTSYIP GSIPCSLLES YLETSSKCPK PGVIFLTKNG RRLCVSPSNK
110 120
QVLACRIMLK LATRIKTRKN
Length:120
Mass (Da):12,932
Last modified:March 1, 2003 - v1
Checksum:i4FE761D77B67BE01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449276 mRNA. Translation: AAN76080.1.
RefSeqiNP_001028118.1. NM_001032946.1.
UniGeneiMmu.1186.

Genome annotation databases

GeneIDi574366.
KEGGimcc:574366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449276 mRNA. Translation: AAN76080.1.
RefSeqiNP_001028118.1. NM_001032946.1.
UniGeneiMmu.1186.

3D structure databases

ProteinModelPortaliQ8HYP4.
SMRiQ8HYP4. Positions 44-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574366.
KEGGimcc:574366.

Organism-specific databases

CTDi6368.

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP4.
KOiK05511.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL23_MACMU
AccessioniPrimary (citable) accession number: Q8HYP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.