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Q8HYP4

- CCL23_MACMU

UniProt

Q8HYP4 - CCL23_MACMU

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Protein

C-C motif chemokine 23

Gene

CCL23

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 (By similarity).By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 23
Alternative name(s):
Small-inducible cytokine A23
Gene namesi
Name:CCL23
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 12099C-C motif chemokine 23PRO_0000005230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 78By similarity
Disulfide bondi55 ↔ 94By similarity
Disulfide bondi65 ↔ 105By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001256.

Structurei

3D structure databases

ProteinModelPortaliQ8HYP4.
SMRiQ8HYP4. Positions 44-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG136395.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8HYP4.
KOiK05511.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HYP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSVAALSC LMLVTALGSQ AQVTNDAETG FMMSKLSLAN SEVLDSFHAI
60 70 80 90 100
NADCCTSYIP GSIPCSLLES YLETSSKCPK PGVIFLTKNG RRLCVSPSNK
110 120
QVLACRIMLK LATRIKTRKN
Length:120
Mass (Da):12,932
Last modified:March 1, 2003 - v1
Checksum:i4FE761D77B67BE01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF449276 mRNA. Translation: AAN76080.1.
RefSeqiNP_001028118.1. NM_001032946.1.
UniGeneiMmu.1186.

Genome annotation databases

GeneIDi574366.
KEGGimcc:574366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF449276 mRNA. Translation: AAN76080.1 .
RefSeqi NP_001028118.1. NM_001032946.1.
UniGenei Mmu.1186.

3D structure databases

ProteinModelPortali Q8HYP4.
SMRi Q8HYP4. Positions 44-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000001256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 574366.
KEGGi mcc:574366.

Organism-specific databases

CTDi 6368.

Phylogenomic databases

eggNOGi NOG136395.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q8HYP4.
KOi K05511.

Miscellaneous databases

NextBioi 19967586.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines."
    Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.
    Cytokine 18:140-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL23_MACMU
AccessioniPrimary (citable) accession number: Q8HYP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3